Planta Med 2009; 75(2): 163-167
DOI: 10.1055/s-0028-1088391
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Biologically Active Triterpenoids from Cephalaria ambrosioides

Sofia Pasi1 , Nektarios Aligiannis1 , Harris Pratsinis1 , 2 , Alexios-Leandros Skaltsounis1 , Ioanna B. Chinou1
  • 1Department of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Athens, Greece
  • 2Present address: Laboratory of Cell Proliferation & Ageing, Institute of Biology, NCSR ”Demokritos”, Athens, Greece
Further Information

Publication History

Received: May 18, 2007 Revised: September 29, 2008

Accepted: October 6, 2008

Publication Date:
16 January 2009 (online)

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Abstract

The roots of Cephalaria ambrosioides yielded a new triterpene, 6α-hydroxyhederagenic acid (1), in addition to the known triterpene hederagenic acid (2) and four corresponding saponins, leontoside A (or akeboside Stb) (3), kalopanax saponin A (or α-hederin) (4), saponin PG (or sapindoside B) (5), and dipsacoside B (6). Their structures have been elucidated on the basis of their spectral data (MS, 1 D and 2 D NMR) and by some chemical transformations. The extract and all isolated compounds were evaluated for their antimicrobial, molluscicidal and in vitro cytotoxic activities. All compounds showed strong antimicrobial activity (MIC values 1.80 – 2.50 μg/mL), with 5 and 6 exhibiting activities comparable to those of standard antibiotics. Moreover, compounds 35 were active against all assayed cancer cell lines, whereas compounds 3 and 4 exhibited higher activities against Biomphalaria glabrata snails, with minimum inhibitory concentrations of 5.4 and 6.2 μg/mL, respectively.

References

Prof. Dr. Ioanna B. Chinou

Department of Pharmacognosy and Chemistry of Natural Products

School of Pharmacy

University of Athens

University Campus of Zografou

157 71 Athens

Greece

Phone: +30-210-727-4595

Fax: +30-210-727-4115

Email: ichinou@pharm.uoa.gr