Semin intervent Radiol 2008; 25(3): 204-215
DOI: 10.1055/s-0028-1085930
© by Thieme Medical Publishers

An Overview of Embolic Agents

Sandeep Vaidya1 , Kathleen R. Tozer1 , Jarvis Chen1
  • 1Department of Radiology, University of Washington, Seattle, Washington
Further Information

Publication History

Publication Date:
30 September 2008 (online)

ABSTRACT

Therapeutic embolization is a common procedure in interventional radiology. A wide variety of agents are available, and each has its own place and use. Additionally, many new agents have appeared on the market in the past several years. The aim of this review article is to give a brief description of available agents, guide appropriate selection, and familiarize the reader regarding appropriate use and limitations.

REFERENCES

  • 1 Speakman T J. Internal occlusion of a carotid-cavernous fistula.  J Neurosurg. 1964;  21 303-315
  • 2 Patel A A, Soulen M C. Agents for small vessel/tissue embolization and transcatheter tissue ablation. In: Baum S, Pentecost MJ Abrams' Angiography Interventional Radiology. 2nd ed. Philadelphia; Lippincott Williams & Wilkins 2006: 169-175
  • 3 Tadavarthy S M, Moller J H, Amplatz K. Polyvinyl alcohol (Ivalon)–a new embolic material.  Am J Roentgenol Radium Ther Nucl Med. 1975;  125(3) 609-616
  • 4 Tadavarthy S M, Knight L, Ovitt T W, Snyder C, Amplatz K. Therapeutic transcatheter arterial embolization.  Radiology. 1974;  112 13-16
  • 5 Derdeyn C P, Moran C J, DeWitte T C, Dietrich H H, Dacey J, Ralph G. Polyvinyl alcohol particle size and suspension characteristics.  AJNR Am J Neuroradiol. 1995;  16 1335-1343
  • 6 Derdeyn C P, Graves V B, Salamat M S, Rappe A. Collagen-coated acrylic microspheres for embolotherapy: in vivo and in vitro characteristics.  AJNR Am J Neuroradiol. 1997;  18 647-653
  • 7 Quisling R G, Mickle J P, Ballinger W B, Carver C C, Kaplan B. Histopathologic analysis of intraarterial polyvinyl alcohol microemboli in rat cerebral cortex.  AJNR Am J Neuroradiol. 1984;  5(1) 101-104
  • 8 Spies J B, Cornell C, Worthington-Kirsch R, Lipman J C, Benenati J F. Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study.  J Vasc Interv Radiol. 2007;  18(2) 203-207
  • 9 Laurent A, Beaujeux R, Wassef M et al.. Trisacryl gelatin microspheres for therapeutic embolization, I: development and in vitro evaluation.  AJNR Am J Neuroradiol. 1996;  17 533-540
  • 10 Beaujeux R, Laurent A, Wassef M et al.. Trisacryl gelatin microspheres for therapeutic embolization II: preliminary clinical evaluation in tumors and arteriovenous malformations.  AJNR Am J Neuroradiol. 1996;  17(3) 541-548
  • 11 Gianturco C, Anderson J H, Wallace S. Mechanical devices for arterial occlusion.  Am J Roentgenol Radium Ther Nucl Med. 1975;  124(3) 428-435
  • 12 Goldstein H M, Wallace S, Anderson J H, Bree R L, Gianturco C. Transcatheter occlusion of abdominal tumors.  Radiology. 1976;  120(3) 539-545
  • 13 Wallace S, Gianturco C, Anderson J H et al.. Therapeutic vascular occlusion utilizing steel coil technique: clinical applications.  AJR Am J Roentgenol. 1976;  127(3) 381-387
  • 14 Chuang V P, Wallace S, Gianturco C, Soo C S. Complications of coil embolization: prevention and management.  AJR Am J Roentgenol. 1981;  137(4) 809-813
  • 15 Vrachliotis T G, Falagas M E. Infections after endovascular coil embolization.  J Endovasc Ther. 2007;  14(6) 805-806
  • 16 Osuga K, Mikami K, Higashihara H et al.. Principles and techniques of transcatheter embolotherapy for peripheral vascular lesions.  Radiat Med. 2006;  24(4) 309-314
  • 17 Cook .Cook peripheral vascular. Available at: http://wwwcookmedicalcom/di/familyListingActiondo?family=Embolization + and + Occlusion Accessed Nov. 9, 2007
  • 18 Ha-Kawa S K, Kariya H, Murata T, Tanaka Y. Successful transcatheter embolotherapy with a new platinum microcoil: the Berenstein liquid coil.  Cardiovasc Intervent Radiol. 1998;  21(4) 297-299
  • 19 Kallmes D F, Fujiwara N H. New expandable hydrogel-platinum coil hybrid device for aneurysm embolization.  AJNR Am J Neuroradiol. 2002;  23(9) 1580-1588
  • 20 Ding Y H, Dai D, Lewis D A, Cloft H J, Kallmes D F. Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix, and HydroCoil.  AJNR Am J Neuroradiol. 2005;  26(7) 1757-1763
  • 21 Serbinenko F A. Balloon catheterization and occlusion of major cerebral vessels.  J Neurosurg. 1974;  41(2) 125-145
  • 22 Tuite D J, Kessel D O, Nicholson A A et al.. Initial clinical experience using the Amplatzer Vascular Plug.  Cardiovasc Intervent Radiol. 2007;  30(4) 650-654
  • 23 Ha C D, Calcagno D. Amplatzer Vascular Plug to occlude the internal iliac arteries in patients undergoing aortoiliac aneurysm repair.  J Vasc Surg. 2005;  42(6) 1058-1062
  • 24 Pollak J S, White Jr R I. The use of cyanoacrylate adhesives in peripheral embolization.  J Vasc Interv Radiol. 2001;  12 907-913
  • 25 Raffi L, Simonetti L, Cenni P, Leonardi M. Use of Glubran 2 acrylic glue in interventional neuroradiology.  Neuroradiology. 2007;  49 829-836
  • 26 Taki W, Yonekawa Y, Iwata H et al.. A new liquid material for embolization of arteriovenous malformations.  AJNR Am J Neuroradiol. 1990;  11(1) 163-168
  • 27 Onyx Liquid Embolic System. In: Micro Therapeutics Inc. 2003Available at: http://www.ev3.net/neuro/us/liquid-embolics/onyx-liquid-embolic-system.htm Accessed Mar 8, 2008
  • 28 Jahan R, Murayama Y, Gobin Y et al.. Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients.  Neurosurgery. 2001;  48(5) 984-995 discussion 995-987
  • 29 Vanninen R L, Manninen I. Onyx, a new liquid embolic material for peripheral interventions: preliminary experience in aneurysm, pseudoaneurysm, and pulmonary arteriovenous malformation embolization.  Cardiovasc Intervent Radiol. 2007;  30(2) 196-200
  • 30 Becker T A, Kipke D R, Brandon T. Calcium alginate gel: a biocompatible and mechanically stable polymer for endovascular embolization.  J Biomed Mater Res. 2001;  54(1) 76-86
  • 31 Becker T A, Preul M C, Bichard W D, Kipke D R, McDougall C G. Preliminary investigation of calcium alginate gel as a biocompatible material for endovascular aneurysm embolization in vivo.  Neurosurgery. 2007;  60 1119-1128
  • 32 Becker T A, Preul M C, Bichard W D, Kipke D R, McDougall C G. Calcium alginate gel as a biocompatible material for endovascular arteriovenous malformation embolization: six-month results in an animal model.  Neurosurgery. 2005;  56 793-801

Sandeep VaidyaM.D. 

Assistant Professor, Department of Radiology, University of Washington

1959 NE Pacific Street, Box #357115, Seattle, WA 98195

Email: svaidya@u.washington.edu

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