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Vet Comp Orthop Traumatol
DOI: 10.1055/a-2780-8854
Clinical Communication

Intra- and Inter-individual Variability of Platelet-rich Plasma Volume and Cellular Composition, and Associated Clinical Outcomes in Dogs Treated for Elbow Dysplasia

Authors

  • Julien B. Cabassu

    1   Clinique Vétérinaire Cabassu, Marseille, France

  • Jeremy Magalon

    2   Cell Culture and Therapy Laboratory, La Conception University Hospital, Aix-Marseille University, Marseille, France

  • Julien Feline

    3   Clinique Vetaurelia, Saint-Raphael, France
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Abstract

Platelet-rich plasma (PRP) is a biological product commonly used in veterinary orthopaedics. There is a lack of descriptive information of the final product used in clinical studies.

Objective

The objectives were to describe and analyze the intra-individual variability of the quantity and cellular composition of the autologous conditioned plasma (ACP) obtained at various time points in each patient in a group of dogs suffering from elbow dysplasia, and to describe the outcome from an owner's perception.

Study Design

Dogs diagnosed with elbow dysplasia treated with three ACP injections 1 week apart were included. A complete blood count on whole blood and ACP was documented in at least two infiltrations. Volume of ACP and degree of platelet increased concentration factor, leukocyte and red blood cell decreased reduction factor were evaluated at each time point. Intra-individual variability of ACP characteristics, mean ACP volume collected and injected, and number of injected platelets were analyzed. Canine brief pain inventory (CBPI) scores were recorded.

Results

In this study 23 dogs were included. No difference was observed in intra-individual ACP volume collected, leukocyte reduction factor and red blood cell reduction factor, or number of platelets injected at various time points, while a significant difference was observed in intra-individual platelets concentration factor. The CBPI scores decreased between pre- and post-injection scores in the majority of the patients.

Conclusion

Regarding ACP, platelets concentration factor is variable in the same patient at various time points while the volume collected and the purity are stable.

Keywords

dogs - elbow dysplasia - regenerative therapies - platelet-rich plasma

Contributors' Statement

J.B.C. contributed to conceptualization, data curation, methodology, writing—original draft, writing—review and editing; J.M. contributed to conceptualization, supervision; J.A.F. contributed to conceptualization, formal analysis, methodology.


Supplementary Material



Publication History

Received: 15 May 2025

Accepted: 02 January 2026

Article published online:
19 January 2026

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