Percutaneous Cryoablation for the Management of Bone and Soft Tissue Tumors

Abstract

Image-guided percutaneous cryoablation plays an increasingly important role in managing bone and soft tissue tumors. Well-established indications include the treatment of osteoid osteoma, palliation of painful skeletal metastases, and local control of oligometastatic disease. Emerging indications are now a variety of painful benign bone tumors beyond osteoid osteoma, symptomatic soft tissue lesions (such as desmoid fibromatosis, vascular anomalies, abdominal wall endometriosis), as well as local recurrences of bone and soft tissue sarcoma. This state-of-the-art review describes the percutaneous cryoablation technique including current strategies to prevent complications. We also discuss the expanding range of clinical indications, as well as future directions of this promising technology in the musculoskeletal system.

Keywords

cryoablation - bone neoplasms - soft tissue neoplasms - osteoid osteoma - bone metastases

Publication History

Received: 11 July 2025

Accepted: 10 November 2025

Article published online:
20 February 2026

• References

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