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DOI: 10.1055/a-2716-7304
Shoulder Injuries in Patients with Epilepsy – a Multidisciplinary Approach
Article in several languages: English | deutschAuthors
Abstract
The management of shoulder injuries resulting from epileptic seizures presents a particular challenge. These injuries often present complex patterns, ranging from dislocations and fractures to damage to the rotator cuff. Recurrent seizures can significantly impact the outcome and must be considered a central risk factor when choosing the therapeutic approach. Accordingly, these injuries require close multidisciplinary cooperation between orthopaedics/trauma surgery, neurology/epileptology and physiotherapy, both in diagnosis and treatment. Despite their clinical relevance, standardised treatment algorithms are currently lacking, and the available scientific evidence remains limited. This review article addresses the specific characteristics of seizure-related shoulder injuries within a multidisciplinary approach. Epidemiological aspects, including pathomechanical principles, diagnostic challenges, and current conservative and surgical treatment options, are discussed.
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Need for interdisciplinary management between orthopaedics/trauma surgery, neurology/epileptology and physiotherapy
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Recurrence is the main risk factor for the success of therapy
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Consideration of the indication for antiseizure medication after a first seizure; if necessary, adjustment of therapy for chronic epilepsy
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Avoiding potentially provocative factors
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Seizure control is critical!
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Consideration of specific pathology – including deeper and larger Hill-Sachs lesions than in classic traumatic dislocations
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Individual treatment choice taking into account the underlying pathology, seizure activity, functional demands and compliance
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Conservative therapy often yields inadequate results
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Bone stabilisations are superior to soft tissue procedures for seizure-related instability.
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Postoperative neurological/epileptological care with the aim of the best possible seizure control as an integral part of surgical management
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Notwendigkeit eines interdisziplinären Managements zwischen Orthopädie/Unfallchirurgie, Neurologie/Epileptologie und Physiotherapie
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zentraler Risikofaktor des Therapieerfolges ist der Rezidivanfall
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Indikationsprüfung einer antisuppressiven Medikation nach einem ersten Anfall, ggf. Therapieanpassung bei chronischer Epilepsie
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Vermeidung potenzieller Provokationsfaktoren
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Förderung der Compliance
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Die Anfallskontrolle ist entscheidend!
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Berücksichtigung der spezifischen Pathologie – u. a. tiefere und größere Hill-Sachs Läsionen als klassisch traumatische Luxationen
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Individuelle Therapiewahl unter Berücksichtigung der zugrunde liegenden Pathologie, Anfallsaktivität sowie funktionellen Anspruch und Compliance
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Konservative Therapie zeigt oft unzureichende Ergebnisse
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Knöcherne Stabilisierungen sind weichteiligen Verfahren bei anfallsbedingter Instabilität überlegen – Prüfung alternativer Knochengrafts
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Postoperativ neurologische/epileptologische Betreuung mit dem Ziel der bestmöglichen Anfallskontrolle als integraler Bestandteil des operativen Managements
Publication History
Received: 30 July 2025
Accepted: 01 October 2025
Article published online:
19 January 2026
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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Literatur
- 1 Beghi E, Cornaggia C. Morbidity and accidents in patients with epilepsy: results of a European cohort study. Epilepsia 2002; 43: 1076-1083
- 2 Kwon CS, Liu M, Quan H. et al. The incidence of injuries in persons with and without epilepsy--a population-based study. Epilepsia 2010; 51: 2247-2253
- 3 Cucchi D, Walter SG, Baumgartner T. et al. Poor midterm clinical outcomes and a high percentage of unsatisfying results are reported after seizure-related shoulder injuries, especially after posterior proximal humerus fracture-dislocations. J Shoulder Elbow Surg 2024; 33: 1340-1351
- 4 Robinson CM, Aderinto J. Posterior shoulder dislocations and fracture-dislocations. J Bone Joint Surg Am 2005; 87: 639-650
- 5 Bühler M, Gerber C. Shoulder instability related to epileptic seizures. J Shoulder Elbow Surg 2002; 11: 339-344
- 6 Grzonka P, Rybitschka A, de Marchis GM. et al. Bone fractures from generalized convulsive seizures and status epilepticus-A systematic review. Epilepsia 2019; 60: 996-1004
- 7 Goudie EB, Murray IR, Robinson CM. Instability of the shoulder following seizures. J Bone Joint Surg Br 2012; 94: 721-728
- 8 Cucchi D, Baumgartner T, Walter SG. et al. Epidemiology and specific features of shoulder injuries in patients affected by epileptic seizures. Arch Orthop Trauma Surg 2023; 143: 1999-2009
- 9 Uppal HS, Robinson PW, Packham I. et al. The management of bilateral posterior fracture dislocations of the shoulder: a case series illustrating management options. Shoulder Elbow 2016; 8: 111-117
- 10 Atwan Y, Wang A, Labrum JT. et al. Management of Shoulder Instability in Patients with Seizure Disorders. Curr Rev Musculoskelet Med 2023; 16: 201-210
- 11 DeToledo JC, Lowe MR, Ramsay RE. Restraining patients and shoulder dislocations during seizures. J Shoulder Elbow Surg 1999; 8: 300-302
- 12 Conradsen I, Wolf P, Sams T. et al. Patterns of muscle activation during generalized tonic and tonic-clonic epileptic seizures. Epilepsia 2011; 52: 2125-2132
- 13 Piana Jacquot FM, Touet A, Menon A. et al. Glenoid bony anatomy in patients with epilepsy is influenced by their tonic-clonic seizure burden. Journal of Shoulder and Elbow Surgery 2025; (in press)
- 14 Salas-Puig X, Iniesta M, Abraira L. et al. Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). Epilepsy Behav 2019; 92: 135-139
- 15 Delattre Sousa S, Houze-Cerfon CH, Le Gourrierec T. et al. Risk factors for the presence of important fractures in ED patients with shoulder dislocation: a retrospective cohort study. Emerg Med J 2022; 39: 662-665
- 16 Persson HBI, Alberts KA, Farahmand BY. et al. Risk of extremity fractures in adult outpatients with epilepsy. Epilepsia 2002; 43: 768-772
- 17 Scheffer IE, Berkovic S, Capovilla G. et al. ILAE-Klassifikation der Epilepsien: Positionspapier der ILAE-Kommission für Klassifikation und Terminologie. Z Epileptol 2018; 31: 296-306
- 18 Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc 1996; 71: 576-586
- 19 Hirtz D, Thurman DJ, Gwinn-Hardy K. et al. How common are the “common” neurologic disorders?. Neurology 2007; 68: 326-337
- 20 Fisher RS, Acevedo C, Arzimanoglou A. et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014; 55: 475-482
- 21 Kwan P, Arzimanoglou A, Berg AT. et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010; 51: 1069-1077
- 22 Kokkalis ZT, Iliopoulos ID, Antoniou G. et al. Posterior shoulder fracture-dislocation: an update with treatment algorithm. Eur J Orthop Surg Traumatol 2017; 27: 285-294
- 23 Hauser WA, Rich SS, Annegers JF. et al. Seizure recurrence after a 1st unprovoked seizure: an extended follow-up. Neurology 1990; 40: 1163-1170
- 24 Chen XY, Zhou FH, Tan G. et al. Risk of recurrence after a first unprovoked seizure with different risk factors: A 10-year prospective cohort study. Epilepsy Res 2024; 207: 107457
- 25 Gardner JS, Blough D, Drinkard CR. et al. Tramadol and seizures: a surveillance study in a managed care population. Pharmacotherapy 2000; 20: 1423-1431
- 26 Morrow RL, Dormuth CR, Paterson M. et al. Tramadol and the risk of seizure: nested case-control study of US patients with employer-sponsored health benefits. BMJ Open 2019; 9: e026705
- 27 Untersuchungstechniken des Schultergelenks. Obere Extremität [Anonym]. 2012; 7: 1-67
- 28 Rowe CR, Zarins B. Recurrent transient subluxation of the shoulder. J Bone Joint Surg Am 1981; 63: 863-872
- 29 Lo IKY, Nonweiler B, Woolfrey M. et al. An evaluation of the apprehension, relocation, and surprise tests for anterior shoulder instability. Am J Sports Med 2004; 32: 301-307
- 30 Gross ML, Distefano MC. Anterior release test. A new test for occult shoulder instability. Clin Orthop Relat Res 1997; (339) 105-108
- 31 Kim SH, Park JS, Jeong WK. et al. The Kim test: a novel test for posteroinferior labral lesion of the shoulder--a comparison to the jerk test. Am J Sports Med 2005; 33: 1188-1192
- 32 Hawkins RJ, Bokor DJ. Clinical evaluation of shoulder problems. In: Rockwood JCA, Matsen IFA. , ed. The Shoulder Vol. 1. Philadelphia: WB Saunders Company; 1990: 149-177
- 33 Deutsche Vereinigung für Schulter- und Ellenbogenchirurgie (DVSE) e. V.. Bildgebung in der Schulter- und Ellenbogenchirurgie. Obere Extremität 2017; 12: 1-84
- 34 Magnussen AP, Watura C, Torr N. et al. Missed posterior shoulder fracture dislocations: a new protocol from a London major trauma centre. BMJ Open Qual 2020; 9: e000550
- 35 Boileau P, Villalba M, Héry JY. et al. Risk factors for recurrence of shoulder instability after arthroscopic Bankart repair. J Bone Joint Surg Am 2006; 88: 1755-1763
- 36 Agha O, Rugg CM, Lansdown DA. et al. Surgical Stabilization of Shoulder Instability in Patients With or Without a History of Seizure: A Comparative Analysis. Arthroscopy 2020; 36: 2664-2673.e3
- 37 Stefaniak J, Lubiatowski P, Kubicka AM. et al. Clinical and radiological examination of bony-mediated shoulder instability. EFORT Open Rev 2020; 5: 815-827
- 38 Chuang TY, Adams CR, Burkhart SS. Use of preoperative three-dimensional computed tomography to quantify glenoid bone loss in shoulder instability. Arthroscopy 2008; 24: 376-382
- 39 Baudi P, Righi P, Bolognesi D. et al. How to identify and calculate glenoid bone deficit. Chir Organi Mov 2005; 90: 145-152
- 40 Bois AJ, Fening SD, Polster J. et al. Quantifying glenoid bone loss in anterior shoulder instability: reliability and accuracy of 2-dimensional and 3-dimensional computed tomography measurement techniques. Am J Sports Med 2012; 40: 2569-2577
- 41 Shin SJ, Kim RG, Jeon YS. et al. Critical Value of Anterior Glenoid Bone Loss That Leads to Recurrent Glenohumeral Instability After Arthroscopic Bankart Repair. Am J Sports Med 2017; 45: 1975-1981
- 42 Shaha JS, Cook JB, Song DJ. et al. Redefining “Critical” Bone Loss in Shoulder Instability: Functional Outcomes Worsen With “Subcritical” Bone Loss. Am J Sports Med 2015; 43: 1719-1725
- 43 Bige B, Gonzalez JF, Boileau P. et al. Epileptic patients with anterior shoulder instability: are there specific bone lesions? A case control study. J Shoulder Elbow Surg 2025; 34: 937-943
- 44 Moroder P, Damm P, Wierer G. et al. Challenging the Current Concept of Critical Glenoid Bone Loss in Shoulder Instability: Does the Size Measurement Really Tell It All?. Am J Sports Med 2019; 47: 688-694
- 45 Rutgers C, Verweij LPE, Priester-Vink S. et al. Recurrence in traumatic anterior shoulder dislocations increases the prevalence of Hill-Sachs and Bankart lesions: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc 2022; 30: 2130-2140
- 46 Burkhart SS, de Beer JF. Traumatic glenohumeral bone defects and their relationship to failure of arthroscopic Bankart repairs: significance of the inverted-pear glenoid and the humeral engaging Hill-Sachs lesion. Arthroscopy 2000; 16: 677-694
- 47 Yamamoto N, Itoi E, Abe H. et al. Contact between the glenoid and the humeral head in abduction, external rotation, and horizontal extension: a new concept of glenoid track. J Shoulder Elbow Surg 2007; 16: 649-656
- 48 Moroder P, Runer A, Kraemer M. et al. Influence of defect size and localization on the engagement of reverse Hill-Sachs lesions. Am J Sports Med 2015; 43: 542-548
- 49 Moroder P, Tauber M, Scheibel M. et al. Defect Characteristics of Reverse Hill-Sachs Lesions. Am J Sports Med 2016; 44: 708-714
- 50 Moroder P, Plachel F, Tauber M. et al. Risk of Engagement of Bipolar Bone Defects in Posterior Shoulder Instability. Am J Sports Med 2017; 45: 2835-2839
- 51 Di Giacomo G, Itoi E, Burkhart SS. Evolving concept of bipolar bone loss and the Hill-Sachs lesion: from “engaging/non-engaging” lesion to “on-track/off-track” lesion. Arthroscopy 2014; 30: 90-98
- 52 Thangarajah T, Lambert SM. Management of recurrent shoulder instability in patients with epilepsy. J Shoulder Elbow Surg 2016; 25: 1376-1384
- 53 Fong S, Darby F, Patel S. et al. Patients With Seizure Disorders Undergoing Surgery for Recurrent Anterior Shoulder Instability Show Variable Rates of Recurrence With Seizures as the Most Common Cause of Failure: A Systematic Review. Arthroscopy 2025;
- 54 Churchill J, Menendez ME, Ponce BA. Early Postoperative Complications After Shoulder Arthroplasty in Patients With Epilepsy. Orthopedics 2016; 39: e1075-e1079
- 55 Dzidzishvili L, Calvo C, Valencia M. et al. Outcomes of Arthroscopic Latarjet Procedure for Anterior Glenohumeral Instability in Patients With Epilepsy: A Case-Control Study. Am J Sports Med 2022; 50: 708-716
- 56 Thangarajah T, Lambert S. The management of recurrent shoulder instability in patients with epilepsy: a 15-year experience. J Shoulder Elbow Surg 2015; 24: 1723-1727
- 57 Bulleit CH, Hurley ET, Jing C. et al. Risk factors for recurrence following arthroscopic Bankart repair: a systematic review. J Shoulder Elbow Surg 2024; 33: 2539-2549
- 58 Purchase RJ, Wolf EM, Hobgood ER. et al. Hill-sachs “remplissage”: an arthroscopic solution for the engaging hill-sachs lesion. Arthroscopy 2008; 24: 723-726
- 59 Guity MR, Sobhani Eraghi A. Mid-term results of arthroscopic Bankart repair and remplissage for recurrent anterior shoulder instability in patients with a history of seizures. BMC Musculoskelet Disord 2022; 23: 12
- 60 Krackhardt T, Schewe B, Albrecht D. et al. Arthroscopic fixation of the subscapularis tendon in the reverse Hill-Sachs lesion for traumatic unidirectional posterior dislocation of the shoulder. Arthroscopy 2006; 22: 227.e1-227.e6
- 61 Bitar AC, Medina G, Ribas L. et al. Arthroscopic Reverse Remplissage in a Bilateral Seizure-related Posterior Shoulder Dislocation: Technique Description and 3-Year Follow-up Case Report. Arch Bone Jt Surg 2021; 9: 350-354
- 62 Cucchi D, Baumgartner T, Touet A. et al. Shoulder Instability in Patients with Seizure Disorders. In: Calvo E, Di Giacomo G, Mazzocca AD. , ed. Complex and Revision Problems in Shoulder Instability. Cham: Springer Nature Switzerland; 2025: 131-147
- 63 Raiss P, Lin A, Mizuno N. et al. Results of the Latarjet procedure for recurrent anterior dislocation of the shoulder in patients with epilepsy. J Bone Joint Surg Br 2012; 94: 1260-1264
- 64 Thon SG, Branche K, Houck DA. et al. Effectiveness of Latarjet for anterior shoulder instability in patients with seizure disorder. JSES Int 2021; 5: 171-174
- 65 Erşen A, Bayram S, Birişik F. et al. The effectiveness of the Latarjet procedure for shoulder instability in patients with epilepsy. Orthop Traumatol Surg Res 2017; 103: 1277-1282
- 66 Hurley ET, Matache BA, Wong I. et al. Anterior Shoulder Instability Part II-Latarjet, Remplissage, and Glenoid Bone-Grafting-An International Consensus Statement. Arthroscopy 2022; 38: 224-233.e6
- 67 Hutchinson JW, Neumann L, Wallace WA. Bone buttress operation for recurrent anterior shoulder dislocation in epilepsy. J Bone Joint Surg Br 1995; 77: 928-932
- 68 Mittal R, Jain S. Eden-Hybinette Procedure for Revision Surgery in Recurrent Anterior Shoulder Instability in Epilepsy. Indian J Orthop 2021; 55: 728-733
- 69 Liles JL, Ganokroj P, Peebles AM. et al. Fresh Distal Tibial Allograft: An Updated Graft Preparation Technique for Anterior Shoulder Instability. Arthrosc Tech 2022; 11: e1027-e1031
- 70 Banerjee M, Balke M, Bouillon B. et al. Excellent results of lesser tuberosity transfer in acute locked posterior shoulder dislocation. Knee Surg Sports Traumatol Arthrosc 2013; 21: 2884-2888
- 71 Stachowicz RZ, Romanowski JR, Wissman R. et al. Percutaneous balloon humeroplasty for Hill-Sachs lesions: a novel technique. J Shoulder Elbow Surg 2013; 22: e7-e13
- 72 Ratner D, Backes J, Tokish JM. Arthroscopic Reduction and Balloon Humeroplasty in the Treatment of Acute Hill-Sachs Lesions. Arthrosc Tech 2016; 5: e1327-e1332
- 73 Gerber C, Catanzaro S, Jundt-Ecker M. et al. Long-term outcome of segmental reconstruction of the humeral head for the treatment of locked posterior dislocation of the shoulder. J Shoulder Elbow Surg 2014; 23: 1682-1690
- 74 Roach RP, Crozier MW, Moser MW. et al. Management of bipolar shoulder injuries with humeral head allograft in patients with active, uncontrolled seizure disorder: case series and review of literature. JSES Int 2022; 6: 132-136
- 75 Heilmann LF, Katthagen JC, Raschke MJ. et al. Promising Mid-Term Outcomes after Humeral Head Preserving Surgery of Posterior Fracture Dislocations of the Proximal Humerus. J Clin Med 2021; 10
- 76 Warnhoff M, Jensen G, Dey Hazra RO. et al. Double plating – surgical technique and good clinical results in complex and highly unstable proximal humeral fractures. Injury 2021; 52: 2285-2291
- 77 Biermann N, Prall WC, Böcker W. et al. Augmentation of plate osteosynthesis for proximal humeral fractures: a systematic review of current biomechanical and clinical studies. Arch Orthop Trauma Surg 2019; 139: 1075-1099
- 78 Königshausen M, Rausch V, Mempel E. et al. Die beidseitige proximale Humerusfraktur – eine seltene Kombination mit hoher Komplikationsrate nach operativer Versorgung. Z Orthop Unfall 2018; 156: 646-652
- 79 Torrens C, Santana F, Melendo E. et al. Osteochondral autograft and hemiarthroplasty for bilateral locked posterior dislocation of the shoulder. Am J Orthop (Belle Mead NJ) 2012; 41: 362-364
- 80 Zanini B, Rusconi M, Fornara P. et al. Bilateral neglected posterior dislocation of the shoulder treated by reverse arthroplasty and contralateral osteochondral autograft. A case report. Trauma Case Reports 2021; 33: 100455
- 81 Crowley M, Ghattas Y, Collins AP. et al. Systematic Review and Meta-Analysis of Locked Posterior Dislocation of the Shoulder Treated with Shoulder Arthroplasty: Improved Outcomes for Total Shoulder Arthroplasty are Associated with Increased Age. Orthop Surg 2023; 15: 1730-1741
- 82 Davies A, Lloyd T, Sabharwal S. et al. Anatomical shoulder replacements in young patients: A systematic review and meta-analysis. Shoulder Elbow 2023; 15: 4-14
- 83 Thangarajah T, Falworth M, Lambert SM. Anatomical shoulder arthroplasty in epileptic patients with instability arthropathy and persistent seizures. J Orthop Surg (Hong Kong) 2017; 25: 2309499017717198
