Exp Clin Endocrinol Diabetes 2025; 133(02): 92-97
DOI: 10.1055/a-2460-7066
Article

Efficacy of Low-Density Lipoprotein Cholesterol Apheresis in the Treatment of Familial Hypercholesterolemia: Single Center Experience

Hulya Hacisahinogullari
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Gamze Bilik Oyman
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Ummu Mutlu
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Senem Dadin
2   Department of Internal Medicine, Division of Hematology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Gulsah Y. Yalin
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Ozlem Soyluk
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Nurdan Gul
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Sevgi Kalayoglu Besisik
2   Department of Internal Medicine, Division of Hematology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Ilhan Satman
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Kubilay Karsidag
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
,
Ayse Kubat Uzum
1   Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (Ringgold ID: RIN64041)
› Author Affiliations
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Abstract

Purpose  Familial hypercholesterolemia (FH) is a genetic disorder associated with extremely high levels of low-density lipoprotein cholesterol (LDL-C) and increased incidence of cardiovascular disease. We aimed to evaluate the efficacy and long-term outcomes of lipoprotein apheresis (LA) in the treatment of FH.

Methods  Cardiovascular events that occurred before and after LA treatment were evaluated by reviewing previous medical records of patients with FH.

Results  Thirteen patients (female/male: 8/5) were included in this study. The mean Dutch score was 20±4. All patients were treated with a combination of statin and ezetimibe. Before the onset of LA, 8 patients had a history of coronary artery disease, and the median age at onset of cardiovascular disease (CVD) in these patients was 24 years. At the initiation of LA, the median age was 22 years and the mean LDL-C level was 410±130 mg/dL. The mean duration of LA treatment was 13.9±6.9 years. The mean LDL-C levels before and after the latest three LA treatments were 267±63.4 and 71.5±23.4 mg/dL, respectively. The mean reduction in LDL-C levels after LA was 73±8.2%. De novo cardiovascular events occurred in 10 patients during LA treatment; six of these patients had a known history of CVD before LA. Eight of these patients underwent invasive procedures for therapeutic purposes and the total number of procedures was 12.

Conclusion  LA is an effective method of reducing LDL-C levels and an additional treatment option that may slow disease progression in patients with FH who are at high risk of cardiovascular events.



Publication History

Received: 02 July 2024

Accepted after revision: 29 October 2024

Article published online:
04 December 2024

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