Mikrobiom und Schwangerschaft

Thomas Hardtmuth

doi:10.1055/a-2442-6480

Hebamme, Inhaltsverzeichnis

Hebamme 2025; 38(01): 16-24
DOI: 10.1055/a-2442-6480

CNE Schwerpunkt

Immunkompetenz

Mikrobiom und Schwangerschaft

Thomas Hardtmuth

Abstract

Das Mikrobiom spielt eine wichtige Rolle für die gesunde Entwicklung eines Kindes. Die Weichen hierfür werden bereits in der Schwangerschaft gestellt, nämlich durch ein vielfältiges Mikrobiom der Mutter. Während der Schwangerschaft zeigen sich neben Hormonschwankungen, Veränderungen der Körperstruktur, des Immunsystems und der Psyche auch Abwandlungen des Mikrobioms. Dies hat Konsequenzen für die mikrobiotische Besiedelung des Kindes.

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Referenzen

Literatur
1 Batra P, Saha A, Faridi MMA. Thermometry in children. J Emerg Trauma Shock 2012; 5: 246-249
2 Kirby TO, Ochoa-Repáraz J. The gut microbiome in multiple sclerosis: A potential therapeutic avenue. Med Sci (Basel) 2018; 6: 69
3 Sait AM, Day PJR. Interconnections between the gut microbiome and alzheimerʼs disease: Mechanisms and therapeutic potential. Int J Mol Sci 2024; 25: 8619
4 Sampson TR, Debelius JW, Thron T. et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson's disease. Cell 2016; 167: 1469-1480 e12
5 Čoklo M, Jonjić A, Dolanc I. et al. Effects of contaminants (heavy metals) on the microbiota status in humans. In: Goel G, Requena T, Bansal S, Hrsg. Human-gut microbiome: Establishment and interactions. London: Academic Press; 2022: 303-311
6 Requena T, Solo de Zaldívar B, Peláez C. et al. Dietary influence on human microbiome. In: Goel G, Requena T, Bansal S, Hrsg. Human-gut microbiome: Establishment and interactions. London, England: Academic Press; 2022: 59-80
7 Martin WF, Sousa FL. Early microbial evolution: The age of anaerobes. Cold Spring Harb Perspect Biol 2015; 8 a 018127
8 Wassermann B, Müller H, Berg G. An Apple a day: Which bacteria do we eat with organic and conventional apples?. Front Microbiol 2019; 10: 1629
9 Qin J, Li R, Raes J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65
10 Hardtmuth T. Mikrobiom und Mensch: Die Bedeutung der Mikroorganismen und Viren in Medizin, Evolution und Ökologie: Wege zu einer systemischen Perspektive. 2., überarbeitete und erweiterte Aufl. Berlin: Salumed; 2024
11 Aagaard K, Ma J, Antony KM. et al. The placenta harbors a unique microbiome. Sci Transl Med 2014; 6: 237ra65
12 Kaisanlahti A, Turunen J, Byts N. et al. Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles. Microbiome 2023; 11: 249
13 Samuel M, Bleackley M, Anderson M. et al. Extracellular vesicles including exosomes in cross kingdom regulation: A viewpoint from plant-fungal interactions. Front Plant Sci 2015; 6: 766
14 Kort R, Caspers M, van de Graaf A. et al. Shaping the oral microbiota through intimate kissing. Microbiome 2014; 2: 41
15 Manca S, Upadhyaya B, Mutai E. et al. Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns. Sci Rep 2018; 8: 11321
16 Chin AR, Fong MY, Somlo G. et al. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res 2016; 26: 217-228
17 Kalarikkal SP, Sundaram GM. Edible plant-derived exosomal microRNAs: Exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2. Toxicol Appl Pharmacol 2021; 414: 115425
18 Han YW. Oral health and adverse pregnancy outcomes – what's next?. J Dent Res 2011; 90: 289-293
19 Attri S, Bansal S, Goel G. An introduction to human gut microbiome. In: Goel G, Requena T, Bansal S, Hrsg. Human-gut microbiome: Establishment and interactions. London: Academic Press; 2022: 3-14
20 Wang S, Liu Y, Tam WH. et al. Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring. Cell Host Microbe 2024; 32: 1192-1206.e5
21 Gunawan WB, Abadi MNP, Fadhillah FS. et al. The interlink between climate changes, gut microbiota, and aging processes. Human Nutrition & Metabolism 2024; 12: 118
22 Desplats PA. Perinatal programming of neurodevelopment: epigenetic mechanisms and the prenatal shaping of the brain. Adv Neurobiol 2015; 10: 335-361
23 Cookson H, Granell R, Joinson C. et al. Mothersʼ anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol 2009; 123: 847-53.e11
24 Chan JC, Morgan CP, Adrian Leu N. et al. Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment. Nat Commun 2020; 11: 1499
25 Varela RB, Cararo JH, Tye SJ. et al. Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neurosci Biobehav Rev 2022; 135: 104579
26 Bartlett AA, Singh R, Hunter RG. Anxiety and epigenetics. In: Delgado-Morales R, Hrsg. Neuroepigenomics in Aging and Disease. 1. Aufl. Cham: Springer International; 2017: 145-166
27 Ziegler C. Epigenetic mechanisms in the pathogenesis and therapy of anxiety disorders [Doctoral thesis]. Würzburg: Universität Würzburg; 2016
28 Li Y. Epigenetic Mechanisms link maternal diets and gut microbiome to obesity in the offspring. Front Genet 2018; 9: 342
29 Neitzke U, Harder T, Plagemann A. Intrauterine growth restriction and developmental programming of the metabolic syndrome: A critical appraisal. Microcirculation 2011; 18: 304-311
30 Gagnon R. Placental insufficiency and its consequences. Eur J Obstet Gynecol Reprod Biol 2003; 110: 99-107
31 Miller LE, Lehtoranta L, Lehtinen MJ. Short-term probiotic supplementation enhances cellular immune function in healthy elderly: Systematic review and meta-analysis of controlled studies. Nutr Res 2019; 64: 1-8
32 Geraghty AA, Lindsay KL, Alberdi G. et al. Nutrition during pregnancy impacts offspringʼs epigenetic status-evidence from human and animal Studies. Nutr Metab Insights 2016; 8: 41-47
33 Meaney MJ, Szyf M. Maternal care as a model for experience-dependent chromatin plasticity. Trends Neurosci 2005; 28: 456-463
34 Gottschalk MG, Domschke K. Genetische Aspekte in der Ätiologie und Therapie von Angsterkrankungen. In: Zwanzger P, Beckman D, Hrsg. Angst: Medizin. Psychologie. Gesellschaft. 1. Aufl. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft; 2019: 119-129
35 Woo V, Alenghat T. Epigenetic regulation by gut microbiota. Gut Microbes 2022; 14: 2022407
36 Li Z, Zhang Y, Wang L. et al. Microbiota of pregnancy, placenta and newborns in the third trimester: A randomized controlled study. Heliyon 2024; 10: e24698
37 Xiong Z, Wang Q, Pei S. et al. The causal role of intestinal microbiome in development of pre-eclampsia. Funct Integr Genomics 2023; 23: 127
38 Kindschuh WF, Baldini F, Liu MC. et al. Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome. Nat Microbiol 2023; 8: 246-259
39 Olimi E, Bickel S, Wicaksono WA. et al. Deciphering the microbial composition of biodynamic preparations and their effects on the apple rhizosphere microbiome. Front Soil Sci 2024; 22: 100345
40 Milke F, Rodas-Gaitan H, Meissner G. et al. Enrichment of putative plant growth promoting microorganisms in biodynamic compared with organic agriculture soils. ISME Communications 2024; 4: ycae021
41 Tai S-K, Lin Y-H, Lin C-H. et al. Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: A nationwide cohort study. Eur J Med Res 2024; 29: 189
42 Fenneman AC, Weidner M, Chen LA. et al. Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract. Nat Rev Gastroenterol Hepatol 2023; 20: 81-100
43 Cox LM, Yamanishi S, Sohn J. et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 2014; 158: 705-721
44 Njotto LL, Simin J, Fornes R. et al. Maternal and early-life exposure to antibiotics and the risk of autism and attention-deficit hyperactivity disorder in childhood: A swedish population-based cohort study. Drug Saf 2023; 46: 467-478
45 Gómez JMR. Early colonization of the human gut. In: Goel G, Requena T, Bansal S, eds. Human-gut microbiome: Establishment and interactions. London: Academic Press; 2022: 15-36
46 Bogaert D, van Beveren GJ, de Koff EM. et al. Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites. Cell Host Microbe 2023; 31: 447-460.e6
47 Gieler U, Gieler T, Peters EMJ. et al. Haut und Psychosomatik – Psychodermatologie heute. J Dtsch Dermatol Ges 2020; 18: 1280-1300
48 Bosch TCG. Die mikrobielle Vielfalt erhalten: Hygienemaßnahmen im Rahmen der COVID-19 Pandemie. PZ Prisma. 2020 4.
49 Mullany LC, Darmstadt GL, Khatry SK. et al. Traditional massage of newborns in Nepal: Implications for trials of improved practice. J Trop Pediatr 2005; 51: 82-86