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DOI: 10.1055/a-2263-1933
Impact of Age on the Relationship between Cross-Clamp Time and Mortality in Cardiac Surgery
Abstract
Age is an independent risk factor for mortality even when all known comorbidities are considered. Thus, other factors may additionally contribute to the age-associated risk. We performed a systematic literature search and identified 161 manuscripts, of which 32 studies (18,256 patients) were analyzed. Cross-clamp time correlated with observed mortality. The increase in mortality risk with cross-clamp time was much greater in older patients than in younger patients. The log odds ratio (OR) for age and cross-clamp time was 0.07 and 0.01, respectively, which was highly significant for both independent risk factors. Age accelerates the increase in mortality risk with increasing aortic cross-clamp times.
Keywords
myocardial protection/cardioplegia (including metabolism) - outcomes (includes mortality, morbidity) - cardiopulmonary bypassPublication History
Received: 08 November 2023
Accepted: 04 February 2024
Accepted Manuscript online:
07 February 2024
Article published online:
16 April 2024
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