Alopecia areata – ein Update

Zusammenfassung

Alopecia areata (AA) – der kreisrunde Haarausfall – stellt nach der androgenetischen Alopezie die zweithäufigste Haarverlusterkrankung weltweit dar. Es wird vermutet, dass es infolge des Verlusts des Immunprivilegs des Haarfollikels zu einer Destruktion der Zellen des Haarfollikels kommt. Der konsekutive Haarausfall geht mit erheblichen Auswirkungen auf die Lebensqualität einher. Die Spontanremission liegt insbesondere bei leichteren Verlaufsformen bei bis zu 80%. Es bestehen topische, injizierbare und systemische immunsupprimierende bzw. -modulierende Behandlungsmöglichkeiten. Vielversprechend scheinen v.a. systemisch verabreichte JAK-Inhibitoren zu sein.

Abstract

Alopecia areata (AA) – circular hair loss – is the second most common hair loss disease worldwide after androgenetic alopecia. It is assumed that the loss of the immune privilege of the hair follicle leads to the destruction of the cells of the hair follicle. The consecutive hair loss is associated with considerable effects on quality of life. The spontaneous remission rate, especially in milder forms, can be up to 80%. There are topical, injectable, and systemic immunosuppressive or immunomodulating treatment options available. Systemically administered JAK inhibitors appear to be particularly promising.

Publication History

Article published online:
13 May 2024

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