Dosimetry in a patient with peritoneal dialysis treated with [177Lu]Lu-PSMA-617

Introduction

Based on the phase III Vision trial [177Lu]Lu-PSMA-617 has been approved for patients with advanced castration resistant prostate cancer. However, the optimal dose and how to adjust this dose to the special needs of individual patients remains an open question [1]. This is of particular importance in patients with end-stage renal disease. As the radioligand is subject to renal excretion, decrease of excretion could consecutively lead to higher doses in tumour and healthy organs. It remains unclear how to determine the exact dose for such patients. Here we report the clinical case of a patient with end-stage renal disease who received continuous ambulatory peritoneal dialysis (CAPD) and was presented for treatment with [177Lu]Lu-PSMA-617.

Publikationsverlauf

Eingereicht: 03. August 2023

Angenommen nach Revision: 07. Dezember 2023

Artikel online veröffentlicht:
08. Januar 2024

• Literature

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• 2 Rosar F, Wenner F, Khreish F. et al. Early molecular imaging response assessment based on determination of total viable tumor burden in [(68)Ga]Ga-PSMA-11 PET/CT independently predicts overall survival in [(177)Lu]Lu-PSMA-617 radioligand therapy. Eur J Nucl Med Mol Imaging 2022; 49 (05) 1584-1594
• 3 Alsadi A DM, Bouhali O, O’Doherty J. Towards routine clinical use of dosimetry in [177Lu]Lu-PSMA prostate cancer radionuclide therapy: current effort and future prospectives.. Frontiers in Physics 2022; 10
• 4 de Bakker M, Dominicus N, Meeuwis A. et al. Urinary excretion kinetics of [(177)Lu]Lu-PSMA-617. Eur J Nucl Med Mol Imaging 2023; 50 (12) 3572-3575
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