LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via
                    MiR-135b-3p/ADH1C Axis

Yang Yu; Yanfei Liu

doi:10.1055/a-2184-8945

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2024; 56(03): 244-254
DOI: 10.1055/a-2184-8945

Original Article: Endocrine Research

LncRNA LINC01339 Hinders the Development of Wilms’ Tumor via MiR-135b-3p/ADH1C Axis

Yang Yu

¹Department of Nephrology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China

,

Yanfei Liu

²Department of Oncology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China

› Author Affiliations

Abstract

Wilms’ tumor is a malignant renal cancer that arises within the pediatric urinary system. This study intended to investigate how a novel long non-coding RNA LINC01339 functions in the pathogenesis of Wilms’ tumor. An elevated miR-135b-3p expression as well as reduced levels of LINC01339 and ADH1C were observed in Wilms’ tumor. LINC01339 mediated ADH1C expression by directly binding to miR-135b-3p. The enforced LINC01339 or ADH1C markedly hindered cell growth and migration in Wilms’ tumor. The LINC01339 overexpression also repressed the growth of Wilms’ tumors in vivo, whereas miR-135b-3p overexpression exerted the opposite effects on Wilms’ tumor cells in vitro. Additionally, upregulating miR-135b-3p reversed LINC01339’s effects on the cellular processes of Wilms’ tumor cells, whereas ADH1C overexpression offset the cancer-promoting influence of miR-135b-3p upregulation on Wilms’ tumor progression. Therefore, LINC01339 prevents Wilms’ tumor progression by modulating the miR-135b-3p/ADH1C axis. Our findings substantiate that the LINC01339/miR-135 b-3p/ADH1C regulatory axis has potential to be a target for the treatment of Wilms’ tumor.

Key words

Wilms’ tumor - ADH1C - LINC01339 - lncRNA - miR-135b-3p

Full Text

References

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Supplementary Material

Supplementary Material