Galphimia glauca Cav.,der Kleine Goldregen

Galphimia glauca Cav., Kleiner Goldregen (Malpighiaceae), ist eine in Mexiko endemische Pflanze, die seit präkolumbianischer Zeit therapeutisch verwendet wird. Neben antiallergischen Wirkungen zeigt die Blattdroge auch anxiolytische und sedative Effekte, die in mehreren klinischen Studien bestätigt werden konnten. Für diese pharmakologische Aktivität werden v. a. Galphimine (Nor-seco-Triterpene) verantwortlich gemacht. Relevante toxische Effekte wurden bei der Anwendung nicht beobachtet.

Abstract

Galphimia glauca Cav., Rain of Gold

Galphimia glauca, rain of gold (Malpighiaceae) is a plant endemic to Mexico that has been used therapeutically since pre-Columbian times. In addition to antiallergic effects, the leaf drug also shows anxiolytic and sedative effects, which have been confirmed in several clinical studies. Galphimines (nor-seco triterpenes) are mainly responsible for this pharmacological activity. Relevant toxic effects were not observed during use.

Schlüsselwörter

Galphimia glauca - Kleiner Goldregen - traditionelle Anwendung - Angststörungen - Mexiko

Key words

Galphimia glauca - rain of gold - traditional use - anxiety disorders - Mexico

Publikationsverlauf

Artikel online veröffentlicht:
30. August 2023

• Literatur

• 1 EMA/HMPC. Community herbal monograph on Lavandula angustifolia Miller, flos. EMA/HMPC/734125/2010. London: European Medicines Agency; 2012
• 2 Melzig M. Traditionelle mexikanische Arzneidroge gegen die Angst. Dt Apoth Ztg 2023; 163 (5): 56–58
• 3 https://www.nparks.gov.sg/florafaunaweb/flora/2/0/2024
• 4 https://www.mnhn.fr/fr/galphimie-glauque
• 5 https://lsj.gr/wiki/thryallis
• 6 Sharma A, Angulo-Bejarano PI, Madariaga-Navarrete A. et al. Multidisciplinary investigations on Galphimia glauca: A Mexican medicinal plant with pharmacological potential. Molecules 2018; 23: 2985-2995
• 7 Estrada-Lugo E. Jardín Botánico de Plantas Medicinales Maximino Martínez (1888–1964). Departamento de Fitotecnia, Universidad Autónoma de Chapingo. Chapingo: Mexico; 1985. 15.
• 8 Díaz J. Uso de plantas medicinales de México. In: Instituto Mexicano Para el Estudio de Plantas Medicinales; Editorial Libros de México: México D.F. ; 1976. 329.
• 9 Dorsch W, Bittinger M, Kaas A. et al. Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs. Int Arch Allergy Immunol 1992; 97: 1-7
• 10 Tortoriello J, Ortega A. Sedative Effect of Galphimine B, a Nor-seco-triterpenoid from Galphimia glauca . Planta Med 1993; 59: 398-400
• 11 Prieto-Gómez B, Tortoriello J, Vázquez-Alvarez A. et al. Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Planta Med 2003; 69: 38-43
• 12 Aguilar-Santamaría L, Ramírez G, Herrera-Arellano A. et al. Toxicological and cytotoxic evaluation of standardized extracts of Galphimia glauca . J Ethnopharmacol 2007; 109: 35-40
• 13 Herrera-Arellano A, Jiménez-Ferrer E, Zamilpa A. et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med 2007; 73: 713-717
• 14 Herrera-Arellano A, Jiménez-Ferrer E, Zamilpa A. et al. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med 2012; 78: 1529-1535
• 15 Romero-Cerecero O, Islas-Garduño AL, Zamilpa A. et al. Galphimine-B standardized extract versus alprazolam in patients with generalized anxiety disorder: A ten-week, double-blind, randomized clinical trial. Biomed Res Int 2019; 2019: 1037036
• 16 Romero-Cerecero O, Islas-Garduño AL, Zamilpa A. et al. Therapeutic effectiveness of Galphimia glauca in young people with social anxiety disorder: A pilot study. Evid Based Complement Alternat Med 2018; 2018: 1716939
• 17 Sarris J, Ravindran A, Yatham LN. et al. Clinical guidelines for the treatment of psychiatric disorders with nutraceuticals und phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatment (CANMAT) taskforce. World J Biol Psychiatry 2022; 23: 424-455
• 18 Bittel M, Rakoyzy T Fröhlich A, Langhorst J. Phytotherapie bei psychischen Erkrankungen in medizinischen Leitlinien. Zschr Phytother 2022; 43: 112-120
• 19 Navarro García VM, Gonzalez A, Fuentes M. et al. Antifungal activities of nine traditional Mexican medicinal plants. J Ethnopharmacol 2003; 87: 85-88
• 20 Sharma A, Cardoso-Taketa A, Choi Y. et al. A comparison on the metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca four years later. J Ethnopharmacol 2012; 141: 964-974
• 21 González-Cortázar M, Herrera-Ruiz M, Zamilpa A. et al. Anti-inflammatory activity and chemical profile of Galphimia glauca . Planta Med 2014; 80: 90-96
• 22 González-Cortázar M, Tortoriello J, Alvarez L. Norsecofriedelanes as spasmolytics, advances of structure-activity relationships. Planta Med 2005; 71: 711-716
• 23 Wiesenauer M, Gaus W. Double-blind trial comparing the effectiveness of the homeopathic preparation Galphimia potentiation d6, Galphimia dilution 10(–6) and placebo on pollinosis. Arzneimittelforschung 1985; 35: 1745-1747
• 24 Wiesenauer M, Lüdtke R. The treatment of pollinosis with Galphimia glauca d4 – A randomized placebo-controlled double-blind clinical trial. Phytomedicine 1995; 2: 3-6