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DOI: 10.1055/a-2044-6415
Individuelle Behandlung bei Glaukompatienten mit einem Diabetes mellitus
Pathophysiologie, Komorbiditäten und therapeutische KonsequenzenAuthors

ZUSAMMENFASSUNG
Das Glaukom und der Diabetes mellitus sind zwei in Europa und weltweit häufig vorkommende chronische Erkrankungen, die einer intensiven Therapie bedürfen. Pathophysiologisch werden verschiedene Mechanismen diskutiert, die vor allem beim Vorliegen eines Diabetes mellitus die Entstehung eines Glaukoms begünstigen. Die medikamentöse und chirurgische Einstellung des Augeninnendruckes ist bei Patienten mit einem Diabetes mellitus mit einigen Einschränkungen verbunden, so zeigen die filtrierenden Eingriffe geringere Erfolgsraten als bei nicht an Diabetes erkrankten Glaukompatienten. Neben der rein augenheilkundlich-endokrinologischen Therapie sollte ebenfalls die psychologische Belastung durch zwei chronische Erkrankungen bedacht und in den individuellen Therapieplan aufgenommen werden.
Publication History
Article published online:
17 April 2023
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Literatur
- 1
Tham YC,
Li X,
Wong TY.
et al
Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. Ophthalmology
2014; 121: 2081-2090
Reference Ris Wihthout Link
- 2
Bourne RRA,
Taylor HR,
Flaxman SR.
et al
Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions
1990–2010 A Meta-Analysis. PLoS One 2016; 11: e0162229
Reference Ris Wihthout Link
- 3
Jonas JB,
Aung T,
Bourne RR.
et al
Glaucoma. Lancet 2017; 390: 2183-2193
Reference Ris Wihthout Link
- 4 International Diabetes Federation, ed. IDF Diabetes Atlas, Tenth Edition. Diabetes around the World in 2021. Im Internet. https://diabetesatlas.org/atlas/tenth-edition/ (letzter Zugriff: 28.02.2023)
- 5 American Diabetes Association Standards of Medical Care in Diabetes–2019 Abridged
for Primary Care Providers. Clin Diabetes 2019; 37: 11-34
Reference Ris Wihthout Link
- 6
Teo ZL,
Tham YC,
Yu M.
et al
Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045: Systematic
Review and Metaanalysis. Ophthalmology 2021; 128: 1580-1591
Reference Ris Wihthout Link
- 7 Virtanen A, Haukka J, Loukovaara S. et al Diabetes mellitus and risk of open-angle glaucoma–A population-based follow-up study. Acta Ophthalmol 2022
- 8 Deutsche Diabetes Gesellschaft (DDG), diabetesDE – Deutsche Diabetes-Hilfe, Hrsg. Deutscher Gesundheitsbericht Diabetes 2022. Im Internet. https://www.diabetesde.org/system/files/documents/gesundheitsbericht_2022.pdf (letzter Zugriff: 28.02.2023)
- 9
Li Y,
Mitchell W,
Elze T.
et al
Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep 2021;
21: 38
Reference Ris Wihthout Link
- 10
Hou H,
Moghimi S,
Baxter SL.
et al
Is Diabetes Mellitus a Blessing in Disguise for Primary Open-angle Glaucoma?. J Glaucoma
2021; 30: 1-4
Reference Ris Wihthout Link
- 11
Wang X,
Xu G,
Wang W.
et al
Changes in corneal biomechanics in patients with diabetes mellitus: a systematic review
and meta-analysis. Acta Diabetol 2020; 57: 973-981
Reference Ris Wihthout Link
- 12
Khawaja AP,
Crabb DP,
Jansonius NM.
The role of ocular perfusion pressure in glaucoma cannot be studied with multivariable
regression analysis applied to surrogates. Invest Ophthalmol Vis Sci 2013; 54: 4619-4620
Reference Ris Wihthout Link
- 13
Tielsch JM,
Katz J,
Sommer A.
et al
Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based
assessment. Arch Ophthalmol 1995; 113: 216-221
Reference Ris Wihthout Link
- 14
Charlson ME,
de Moraes CG,
Link A.
et al
Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology
2014; 121: 2004-2012
Reference Ris Wihthout Link
- 15
Su DHW,
Wong TY,
Wong WL.
et al
Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study.
Ophthalmology 2008; 115: 964-968.e1
Reference Ris Wihthout Link
- 16
Shami SK,
Chittenden SJ.
Microangiopathy in diabetes mellitus: II. Features, complications and investigation.
Diabetes Res 1991; 17: 157-168
Reference Ris Wihthout Link
- 17
Bonaventure N,
Roussel G,
Wioland N.
[Stereospecificity of the action of alpha-aminoadipic acid on the retina: a morphological
and electrophysiological study]. C R Seances Acad Sci III 1983; 296: 457-462
Reference Ris Wihthout Link
- 18
Yanagi M,
Kawasaki R,
Wang JJ.
et al
Vascular risk factors in glaucoma: a review. Clin Exp Ophthalmol 2011; 39: 252-258
Reference Ris Wihthout Link
- 19
Sato T,
Roy S.
Effect of high glucose on fibronectin expression and cell proliferation in trabecular
meshwork cells. Invest Ophthalmol Vis Sci 2002; 43: 170-175
Reference Ris Wihthout Link
- 20 Rodrigues GB, Abe RY, Zangalli C. et al Neovascular glaucoma: a review. Int J Retina Vitreous 2016; 02: 26
- 21
Havens SJ,
Gulati V.
Neovascular Glaucoma. Dev Ophthalmol 2016; 55: 196-204
Reference Ris Wihthout Link
- 22 Zhou M, Wang W, Huang W. et al Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. PLoS One 2014; 09: e102972
- 23
Zhao YX,
Chen XW.
Diabetes and risk of glaucoma: systematic review and a Meta-analysis of prospective
cohort studies. Int J Ophthalmol 2017; 10: 1430-1435
Reference Ris Wihthout Link
- 24
Kjærsgaard M,
Grauslund J,
Vestergaard AH.
et al
Relationship between Diabetic Retinopathy and Primary Open-Angle Glaucoma: A Systematic
Review and Meta-Analysis. Ophthalmic Res 2022; 65: 377-386
Reference Ris Wihthout Link
- 25
Hou H,
Shoji T,
Zangwill LM.
et al
Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients. Am
J Ophthalmol 2018; 189: 1-9
Reference Ris Wihthout Link
- 26 European Glaucoma Society (EGS). European Glaucoma Society Guidelines – 5th ed. 2021. Im Internet. https://www.eugs.org/eng/guidelines.asp (letzter Zugriff: 28.02.2023)
- 27
Przezak A,
Bielka W,
Pawlik A.
Hypertension and Type 2 Diabetes–The Novel Treatment Possibilities. Int J Mol Sci
2022; 23: 6500
Reference Ris Wihthout Link
- 28 Siklos P, Henderson RG. Severe acidosis from acetazolamide in a diabetic patient. Curr Med Res Opin 1979; 06: 284-286
- 29
Feldman-Billard S,
Du Pasquier-Fediaevsky L,
Héron E.
Hyperglycemia after repeated periocular dexamethasone injections in patients with
diabetes. Ophthalmology 2006; 113: 1720-1723
Reference Ris Wihthout Link
- 30
Zhang YP,
Peng XY,
Li ZH.
et al
Hyperglycemic effects of a periocular dexamethasone injection in diabetic patients
after vitreoretinal surgery. Biomed Environ Sci 2012; 25: 311-316
Reference Ris Wihthout Link
- 31
Lin HC,
Stein JD,
Nan B.
et al
Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma
in Persons With Diabetes Mellitus. JAMA Ophthalmol 2015; 133: 915-923
Reference Ris Wihthout Link
- 32
Kim YS,
Kim M,
Choi MY.
et al
Metformin protects against retinal cell death in diabetic mice. Biochem Biophys Res
Commun 2017; 492: 397-403
Reference Ris Wihthout Link
- 33
Zhang X,
Hou A,
Cao J.
et al
Association of Diabetes Mellitus With Postoperative Complications and Mortality After
Non-Cardiac Surgery: A Meta-Analysis and Systematic Review. Front Endocrinol (Lausanne)
2022; 13: 841256
Reference Ris Wihthout Link
- 34
Law SK,
Hosseini H,
Saidi E.
et al
Long-term outcomes of primary trabeculectomy in diabetic patients with primary open
angle glaucoma. Br J Ophthalmol 2013; 97: 561-566
Reference Ris Wihthout Link
- 35 Hugkulstone CE, Smith LF, Vernon SA. Trabeculectomy in diabetic patients with glaucoma. Eye (Lond) 1993; 07: 502-506
- 36
Schlenker MB,
Gulamhusein H,
Conrad-Hengerer I.
et al
Efficacy, Safety, and Risk Factors for Failure of Standalone Ab Interno Gelatin Microstent
Implantation versus Standalone Trabeculectomy. Ophthalmology 2017; 124: 1579-1588
Reference Ris Wihthout Link
- 37
Denk PO,
Hoppe J,
Hoppe V.
et al
Effect of growth factors on the activation of human Tenonʼs capsule fibroblasts. Curr
Eye Res 2003; 27: 35-44
Reference Ris Wihthout Link
- 38
Browning AC,
Alibhai A,
McIntosh RS.
et al
Effect of diabetesmellitus and hyperglycemia on the proliferation of human Tenonʼs
capsule fibroblasts: Implications for wound healing after glaucoma drainage surgery.
Wound Repair Regen 2005; 13: 295-302
Reference Ris Wihthout Link
- 39
Saarni SI,
Härkänen T,
Sintonen H.
et al
The impact of 29 chronic conditions on health-related quality of life: a general population
survey in Finland using 15D and EQ-5D. Qual Life Res 2006; 15: 1403-1414
Reference Ris Wihthout Link
- 40
Ko Y,
Coons SJ.
Self-reported chronic conditions and EQ-5D index scores in the US adult population.
Curr Med Res Opin 2006; 22: 2065-2071
Reference Ris Wihthout Link
- 41
Mills T,
Law SK,
Walt J.
et al
Quality of life in glaucoma and three other chronic diseases: a systematic literature
review. Drugs Aging 2009; 26: 933-950
Reference Ris Wihthout Link
- 42 Groff ML, Choi B, Lin T. et al Anxiety, depression, and sleep-related outcomes of glaucoma patients: systematic review and meta-analysis. Can J Ophthalmol. 2022
- 43 Zheng Y, Wu X, Lin X. et al The Prevalence of Depression and Depressive Symptoms among Eye Disease Patients: A Systematic Review and Metaanalysis. Sci Rep 2017; 07: 46453
- 44
Azmiardi A,
Murti B,
Febrinasari RP.
et al
Low Social Support and Risk for Depression in People With Type 2 Diabetes Mellitus:
A Systematic Review and Meta-analysis. J Prev Med Public Health 2022; 55: 37-48
Reference Ris Wihthout Link