Visible-Light-Promoted C(sp3)–H Bond Functionalization toward Aminothiazole Skeletons from Active Methylene Ketones and Thioureas

Renhua Zheng; Xiurong Hu; Huajiang Jiang; Haichang Guo; Lei Wang

doi:10.1055/a-2035-2873

Synthesis, Inhaltsverzeichnis

Synthesis 2023; 55(13): 2091-2098
DOI: 10.1055/a-2035-2873

paper

Special Issue Honoring Prof. Guoqiang Lin's Contributions to Organic Chemistry

Visible-Light-Promoted C(sp³)–H Bond Functionalization toward Aminothiazole Skeletons from Active Methylene Ketones and Thioureas

Autor*innen

Renhua Zheng

^aSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China
Xiurong Hu

^aSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China

^bDepartment of Chemistry, Zhejiang Sci-Tech University, 2 Street 928, Hangzhou, 310018, P. R. of China
Huajiang Jiang

^aSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China
Haichang Guo∗

^aSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China
Lei Wang ∗

^aSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China

^cAdvanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Shifu Avenue 1139, Jiaojiang, 318000, P. R. of China

Abstract

Alle Artikel dieser Rubrik

This paper is dedicated to Professor Guoqiang Lin on the occasion of his 80^th birthday.

Abstract

A novel and efficient visible-light-induced method is developed for the one-pot synthesis of functionalized 2-aminothiazoles from easily accessible active methylene ketone derivatives and different thioureas at room temperature. The mild reaction conditions, green chemistry, straightforward work-up, and high yields of the products make this procedure useful for the construction of 2-aminothiazole derivatives.

Key words

photocatalysis - 2-aminothiazoles - cyclization - free-radical reaction - heterocyclic compounds

Volltext

Referenzen

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