Angeborene und erworbene Immunität im Kontext der nichtalkoholischen Fettlebererkrankung

Zusammenfassung

Die nichtalkoholische Fettlebererkrankung (NAFLD) ist ein wachsendes Gesundheitsproblem. Das Verständnis der immunologischen Vorgänge in der Leber während der Ausbildung sowie Progression der Fettlebererkrankung hin zu einer Fettleberentzündung (NASH), Leberzirrhose oder hepatozellulärem Karzinom (HCC) kann dabei zum besseren Erkrankungsverständnis, Identifizierung von klinisch relevanten Subgruppen sowie therapeutischen Ansätzen genutzt werden. Die Interaktion zwischen angeborenem und erworbenem Immunsystem scheint dabei von großer Wichtigkeit zu sein. Dieser Übersichtsartikel beleuchtet die verschiedenen immunologischen Vorgänge in der NAFLD bis hin zur Progression zum HCC, geordnet nach den wesentlichen Zellgruppen des angeborenen und erworbenen Immunsystems.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a growing health problem. Understanding the immunological processes in the liver during the development and progression of fatty liver disease to fatty liver inflammation (NASH), liver cirrhosis or hepatocellular carcinoma (HCC) can be used to better understand the disease, identify clinically relevant subgroups and therapeutic approaches. The interaction between innate and acquired immune systems seems to be of great importance. This review article highlights the various immunological processes in NAFLD leading up to progression to HCC, organized according to the major cell groups of the innate and acquired immune systems.

Schlüsselwörter

NAFLD - NASH - HCC - Angeborenes Immunsystem - Erworbenes Immunsystem

Keywords

NAFLD - NASH - HCC - Immunsystem - Zytokine

Publication History

Received: 04 October 2022

Accepted after revision: 04 December 2022

Article published online:
09 January 2023

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