Frailty und ihre Bedeutung in der Kopf-Hals-Onkologie

Die Therapie älterer Patienten mit Kopf-Hals-Tumoren ist aufgrund vorbestehender Komorbiditäten häufig eine Herausforderung. Erschwerend hinzu kommt ein Mangel an qualitativ hochwertiger Evidenz zur Therapie dieser Patientengruppe, da sie in der Regel von randomisiert-kontrollierten klinischen Studien ausgeschlossen wird. Dieser Beitrag möchte den Begriff Frailty als komplexes Syndrom erläutern und seine Bedeutung in der Kopf-Hals-Onkologie darstellen.

Abstract

Since treatment of elderly patients with head and neck cancer is often challenging due to preexisting comorbidities, continuous efforts are required to raise awareness for frailty, which is a multidimensional state of diminished physiologic reserve resulting in decreased resiliency and increased vulnerability to stressors. Frailty is a predictor of poor clinical outcomes in head and neck cancer patients, but until now there is no standardization of frailty assessment. Pretherapeutic frailty assessment among head and neck cancer patients should be incorporated into routine multidisciplinary management to predict adverse outcomes and tailor a personalized treatment. This article would like to explain the complex syndrome frailty and its importance for head and neck oncology.

Schlüsselwörter

Gebrechlichkeit - Frailty - Kopf-Hals-Onkologie - geriatrisches Assessment

Publication History

Article published online:
02 February 2023

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