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veterinär spiegel 2023; 33(01): 15-20
DOI: 10.1055/a-1971-1030
Kleintiere & Heimtiere

Fallbericht zur immunologischen Therapie einer chronischen Gingivostomatitis bei der Katze

Sarah Bernauer
,
Zita-Maria Grammel
,
Claudia Dettmer-Richardt
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Die feline chronische Gingivostomatitis ist eine hoch schmerzhafte Erkrankung der Mundhöhle bei Katzen und sorgt für eine erhebliche Einschränkung der Lebensqualität. Lesen Sie unseren spannenden Fallbericht mit der außergewöhnlichen, immunologischen Therapie eines 4 Jahre alten Siamkaters.

Publication History

Article published online:
16 March 2023

© 2023. Thieme. All rights reserved.

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  • Literatur

  • 1 Lipscomb MF, Masten BJ. Dendritic cells: immune regulators in health and disease. Physiol Rev 2002; 82 (01) 97-130
    CrossrefPubMedGoogle Scholar
  • 2 Grammel T, Dettmer-Richardt C, Grammel M. Immuntherapie bei einer Perianalfistel – Ein Fallbericht. Kleintierprax 2014; 60 (08) 414-423
    Google Scholar
  • 3 Morelli AE, Thomson A. Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 2003; 196: 125-146
    CrossrefPubMedGoogle Scholar
  • 4 Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685-711
    PubMedGoogle Scholar
  • 5 Hackstein H, Thomson AW. Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4 (01) 24-34
    CrossrefPubMedGoogle Scholar
  • 6 Morelli A, Thomson A. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007; 7: 61-621
    CrossrefPubMedGoogle Scholar
  • 7 Murray PJ. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci USA 2005; 102: 8686-8691
    PubMedGoogle Scholar
  • 8 Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated antiinflammatory response. Curr Opin Pharma 2006; 6: 379-386
    Google Scholar
  • 9 Laouar Y, Town T, Jeng D. et al. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2008; 105: 10865-10870
    CrossrefPubMedGoogle Scholar
  • 10 Winer JN, Arzi B, Verstraete FJ. Therapeutic management of feline gingivostomatitis: a systemic review of the literature. Front VetSci 2016; 3: 54
    Google Scholar
  • 11 Lommer MJ, Verstraete FJ. Concurrent oral shedding of feline calicivirus and feline herpesvirus 1 in cats with chronic gingivostomatitis. Oral Microbio Immunol 2003; 18: 131-134
    CrossrefPubMedGoogle Scholar
  • 12 Dowers KL, Hawley JR, Brewer MM. et al. Association of Bartonella species, feline calicivirus, and feline herpesvirus 1 infection with gingivostomatitis in cats. J Feline Med Surg 2010; 12 (04) 314-721
    CrossrefPubMedGoogle Scholar
  • 13 Mihaljevic SY. Feline Stomatitis. Tierärztezeitung 2018; 3: 38-43
    Google Scholar
  • 14 Quimby JM, Borjesson DL. Mesenchymal Stem Cell Therapy in Cats – Current Knowledge and future Potential. J Fel Med Surg 2018; 20: 208-216
    CrossrefPubMedGoogle Scholar
  • 15 De Souza AW, Mesquita Júnior D, Araújo JA. et al. Immune System Part III, The delicate balance of the immune system between tolerance and autoimmunity. Rev Bras Reumatol 2010; 50: 665-694
    Google Scholar
  • 16 Ness S, Lin S, Gordon JR. Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease. Front Immunol 2021; DOI: 10.3389/fimmu.2021.633436.
    CrossrefPubMedGoogle Scholar
  • 17 Roncarolo M, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007; 7: 585-598
    CrossrefPubMedGoogle Scholar
  • 18 Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006; 6: 295-307
    CrossrefPubMedGoogle Scholar
  • 19 Ostroukhova M, Seguin-Devaux C, Oriss TB. et al. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane bound TGF-beta and FoxP3. J Clin Invest 2004; 114: 28-38
    PubMedGoogle Scholar
  • 20 Tsuji NM, Kosaka A. Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol 2008; 29: 532-554
    PubMedGoogle Scholar
  • 21 Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity 2009; 31: 412-424
    PubMedGoogle Scholar
  • 22 Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 9: 239-244
    PubMedGoogle Scholar
  • 23 Vignali D, Collison L, Workman C. How regualtory T cells work. Nat Rev Immunol 2008; 8: 523-532
    CrossrefPubMedGoogle Scholar
  • 24 Healey KA, Dawson S, Burrow R. et al. Prevalence of feline chronicgingivo-stomatitis in first opinion veterinary practice. J Fel Med Surg 2007; 9: 373-381
    CrossrefPubMedGoogle Scholar
  • 25 Harley R, Gruffydd-Jones TJ, Day MJ. Immunohistochemical characterization of oral mucosal lesions in cats with chronic gingivostomatitis. J Comp Pathol 2011; 144: 239-250
    CrossrefPubMedGoogle Scholar
  • 26 Hintzen G, Ohl L, del Rio ML. et al. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigentransport to the bronchial lymphnode. J Immunol 2006; 177 (10) 7346-7354
    CrossrefPubMedGoogle Scholar
  • 27 Jang MH, Jang MH, Sougawa N. et al. CCR7 is critically important for migration of dendritic cells in intestinal Lamina Propria to mesenteric lymph nodes. J Immunol 2006; 176: 803-810
    CrossrefPubMedGoogle Scholar
  • 28 Jonuleit H, Schmitt E, Kakirman H. et al. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002; 196: 25-260
    CrossrefPubMedGoogle Scholar
  • 29 Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity 2009; 31: 412-424
    CrossrefPubMedGoogle Scholar
  • 30 Mekala DJ, Alli RS, Geiger TL. IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD+CD25+ T lymphocytes. Proc Natl Acad Sci USA 2005; 174: 11817-11822
    CrossrefPubMedGoogle Scholar
  • 31 Murphy K, Janeway CA, Travers P. et al. Janewayʼs immunobiology. 8. Aufl.. Oxford: Taylor & Francis; 2012
    Google Scholar
  • 32 Murray PJ. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci USA 2005; 102: 8686-8691
    CrossrefPubMedGoogle Scholar
  • 33 Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated antiinflammatory response. Current opinion in pharmacology 2006; 6: 379-386
    CrossrefPubMedGoogle Scholar
  • 34 Ohl L, Mohaupt M, Czeloth N. et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004; 21: 279-288
    CrossrefPubMedGoogle Scholar
  • 35 Ostroukhova M, Seguin-Devaux C, Oriss TB. et al. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane bound TGF-beta and FoxP3. J Clin Invest 2004; 114: 28-38
    CrossrefPubMedGoogle Scholar
  • 36 Peralta S, Carney PC. Feline chronic gingivostomatitis is more prevalent in shared households and its risk correlates with the number of cohabiting cats. J Feline Med Surg 2019; DOI: 10.1177/1098612X18823584.
    CrossrefPubMedGoogle Scholar
  • 37 Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685-711
    CrossrefPubMedGoogle Scholar
  • 38 Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 9: 239-244
    CrossrefPubMedGoogle Scholar
  • 39 Tsuji NM, Kosaka A. Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol 2008; 29: 532-554
    CrossrefPubMedGoogle Scholar
  • 40 Vignali D, Collison L, Workman C. How regualtory T cells work. Nat Rev Immunol 2008; 8: 523-532
    CrossrefPubMedGoogle Scholar
  • 41 Waldmann H, Adams E, Fairchild P. et al. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol Rev 2008; 212: 301-313
    CrossrefPubMedGoogle Scholar
  • 42 Worbs T, Bode U, Yan S. et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006; 203: 519-527
    CrossrefPubMedGoogle Scholar