Idiopathische rekurrierende Perikarditis

ZUSAMMENFASSUNG

Die idiopathische rekurrierende Perikarditis (IRP) umfasst rezidivierende Perikarditis-Episoden, für die keine anderen Ursachen bzw. Auslöser gefunden werden können. Aufgrund ihres inflammatorischen Charakters (meist akute Schmerzattacken mit deutlich erhöhten serologischen Entzündungszeichen sowie gutem Ansprechen auf Colchicin und/oder Interleukin-1-Blockade) mit Rezidivneigung wird die Erkrankung auch als eigenständige autoinflammatorische Erkrankung angesehen. Darüber hinaus können vergleichbare Episoden auch bei anderen autoinflammatorischen Erkrankungen wie dem familiären Mittelmeerfieber (FMF) oder TNF-Rezeptor-assoziierten periodischen Syndrom (TRAPS) auftreten. Der Artikel gibt einen Überblick über die Klinik, Pathophysiologie und Therapie der IRP.

ABSTRACT

Idiopathic recurrent pericarditis (IRP) refers to episodes of recurrent pericarditis for which no other causes or triggers can be identified. Due to the inflammatory character (acute attacks of thoracic pain with increased serological inflammatory markers and a good response to colchicine and/or interleukin-1-blockade) with a tendency to recurrence, the disease is considered an autoinflammatory disease. In addition, comparable episodes can also be other autoinflammatory diseases such as familial Mediterranean fever (FMF) or TNF receptor-associated periodic syndrome (TRAPS). This article provides an overview of the clinic, pathophysiology, and therapy of IRP.

Schlüsselwörter

Autoinflammation - familiäres Mittelmeerfieber - TRAPS - IL-1-Blockade

Keywords

Autoinflammation - Familial Mediterranean Fever - TRAPS - IL-1-blockage

Publication History

Article published online:
07 September 2022

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