Schmerztherapie beim Patienten mit Hufrehe

Eine der größten Herausforderungen bei der Hufrehe-Behandlung bleibt die Schmerzkontrolle. Dabei kann das systemische Schmerzmanagement mit lokalen Techniken wie langanhaltenden Lokalanästhetika oder verschiedenen Arten der Epiduralkatheterisierung kombiniert werden.

Publication History

Article published online:
09 December 2022

• Literatur

• 1 Knights KM, Mangoni AA, Miners JO. Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity. Exp Rev Clin Pharmacol 2010; 3: 769-776
• 2 Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008; 22: 383-390
• 3 Fowler CJ. The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action. Br J Pharmacol 2007; 152: 594-601
• 4 Rouzer CA, Marnett LJ. Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids. J Biolog Chem 2008; 283: 8065-8069
• 5 Hamza M, Dionne RA. Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition. Curr Mol Pharmacol 2009; 2: 1-14
• 6 Sumano Lopez H, Hoyos Sepulveda ML, Brumbaugh GW. Pharmacologic and alternative therapies for the horse with chronic laminitis. Vet Clin North Am Equine Pract 1999; 15: 495-516
• 7 Belknap JK. Treatment of the acute laminitis case. In: Large animal proceedings of the North American Veterinary Conference. Orlando, Florida: 2006: 76-80
• 8 Moore RM. Evidence-based treatment for laminitis – what works?. J Equine Vet Sci 2008; 28: 176-179
• 9 Clark JO, Clark TP. Analgesia. Vet Clin North Am Equine Pract 1999; 15: 705-723
• 10 Moyer W, Schumacher J, Schumacher J. et al. Are drugs effective treatment for horses with acute laminitis?. In: Proceedings of the 54th Annual Convention of the American Association of Equine Practioners, San Diego (CA). 2008: 337-340
• 11 Simon LS. Biology and toxic effects of nonsteroidal anti-inflammatory drugs. Curr Opin Rheumatol 1998; 10: 153-158
• 12 Blikslager A. Role of NSAIDs in the management of pain in horses. In: Proceedings of the American Association of Equine Practioners – Focus Meeting. Raleigh, North Carolina, USA. 2009: 218-223
• 13 Divers TJ. COX inhibitors: Making the best choice for the laminitic case. J Equine Vet Sci 2008; 28: 367-369
• 14 Urdaneta A, Siso A, Urdaneta B. et al. Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib. Brain Res Bull 2009; 80: 56-61
• 15 Bovill JG. Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs. Europ J Anaesthesiol 1997; 14: 9-15
• 16 Surratt CK, Johnson PS, Moriwaki A. et al. µ opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J Biol Chem 1994; 269: 20548-20553
• 17 McFadzean DF. The ionic mechanisms underlying opioid actions. Neuropeptides 1988; 11: 173-180
• 18 Crain SM, Shen KF. Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons. Trends Pharmacol Sci 1990; 11: 77-81
• 19 De Leon-Cassola OA, Lema MJ. Postoperative epidural opioid analgesia: what are the choices?. Anesth Analg 1996; 83: 867-875
• 20 Ferreira SH, Nakamura M. II. Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins 1979; 18: 191-200
• 21 Reid JL. Central alpha 2 receptors and the regulation of blood pressure in humans. J Cardiovasc Pharmacol 1985;7 Suppl 8: 45 – 50.
• 22 Brosda J, Jantschak F, Pertz HH. α2-Adrenoceptors are targets for antipsychotic drugs. Psychopharmacology (Berl) 2014; 231: 801-812
• 23 Gyires K, Zádori ZS, Török T. et al. Alpha2-Adrenoceptor subtypes-mediated physiological, pharmacological actions. Neurochem Int 2009; 55: 447-453
• 24 Asano T, Dohi S, Ohta S. et al. Antinociception by epidural and systemic alpha2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg 2000; 90: 400-440
• 25 Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136
• 26 König KS, Verhaar N, Hopster K. et al. Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion. PLoS One 2020; 15: e0224720
• 27 VanderBroek AR, Engiles JB, Kästner SBR. et al. Protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in horses. Equine Vet J 2021; 53: 569-578
• 28 Attal N, Cruccu G, Baron R. et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Europ J Neurol 2010; 17: 1113-1188
• 29 Moulin DE, Clark AJ, Gilron I. et al. Pharmacological management of chronic neuropathic pain – consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag 2007; 12: 13-21
• 30 Finnerup NB, Attal N, Haroutounian S. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015; 14: 162-173
• 31 Terry RL, McDonnell SM, Van Eps AW. et al. Pharmacokinetic profile and behavioral effects of gabapentin in the horse. J Vet Pharmacol Ther 2010; 33: 485-494
• 32 Davis JL, Posner LP, Elce Y. Gabapentin for the treatment of neuropathic pain in a pregnant horse. J Am Vet Med Assoc 2007; 231: 755-758
• 33 Young JM, Schoonover MJ, Kembel SL. et al. Efficacy of orally administered gabapentin in horses with chronic thoracic limb lameness. Vet Anaesth Analg 2020; 47: 259-266
• 34 Mion G, Villevieille T. Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings). CNS Neurosci Ther 2013; 19: 370-380
• 35 Peltoniemi MA, Hagelberg NM, Olkkola KT. et al. Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin Pharmacokinet 2016; 55: 1059-1077
• 36 Lu W, Wang L, Wo C. et al. Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model. Mol Med Rep 2016; 13: 5013-5020
• 37 Dale O, Somogyi AA, Li Y. et al. Does intraoperative ketamine attenuate inflammatory reactivity following surgery? A systematic review and meta-analysis. Anesth Analg 2012; 115: 934-943
• 38 Müller TM, Hopster K, Bienert-Zeit A. et al. Effect of butorphanol, midazolam or ketamine on romifidine based sedation in horses during standing cheek tooth removal. BMC Vet Res 2017; 13: 381
• 39 Fielding CL, Brumbaugh GW, Matthews NS. et al. Pharmacokinetics and clinical effects of a subanesthetic continuous rate infusion of ketamine in awake horses. Am J Vet Res 2006; 67: 1484-1490
• 40 Guedes AG, Matthews NS, Hood DM. Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain. Am J Vet Res 2012; 73: 610-619
• 41 Hara M, Kai Y, Ikemoto Y. Local anesthetics reduce the inhibitory neurotransmitter-induced current in dissociated hippocampal neurons of the rat. Eur J Pharmacol 1995; 283: 83-89
• 42 Ye JH, Ren J, Krnjevic K. et al. Cocaine and lidocaine have additive inhibitory effects on the GABAA current of acutely dissociated hippocampal pyramidal neurons. Brain Res 1999; 821: 26-32
• 43 Sugimoto M, Uchida I, Fukami S. et al. The alpha and gamma subunit-dependent effects of local anesthetics on recombinant GABA(A) receptors. Eur J Pharmacol 2000; 401: 329-337
• 44 Todorov AA, Kolchev CB, Todorov AB. Tiagabine and gabapentin for the management of chronic pain. Clin J Pain 2005; 21: 358-361
• 45 Sommer C, Leinders M, Uceyler N. Inflammation in the pathophysiology of neuropathic pain. Pain 2018; 159: 595-602
• 46 Giddon DB, Lindhe J. In vivo quantitation of local anesthetic suppression of leukocyte adherence. Am J Pathol 1972; 68: 327-338
• 47 MacGregor RR, Thorner RE, Wright DM. Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites. Blood 1980; 56: 203-209
• 48 Kanbara T, Tomoda MK, Sato EF. et al. Lidocaine inhibits priming and protein tyrosine phosphorylation of human peripheral neutrophils. Biochem Pharmacol 1993; 45: 1593-1598
• 49 Hollmann MW, Gross A, Jelacin N. et al. Local anesthetic effects on priming and activation of human neutrophils. Anesthesiology 2001; 95: 113-122
• 50 Mikawa K, Maekawa N, Nishina K. et al. Effect of lidocaine pretreatment on endotoxin-induced lung injury in rabbits. Anesthesiology 1994; 81: 689-699
• 51 Nishina K, Mikawa K, Maekawa N. et al. Does early posttreatment with lidocaine attenuate endotoxin-induced acute injury in rabbits?. Anesthesiology 1995; 83: 169-177
• 52 Taniguchi T, Shibata K, Yamamoto K. et al. Effects of lidocaine administration on hemodynamics and cytokine responses to endotoxemia in rabbits. Crit Care Med 2000; 28: 755-759
• 53 Kiyonari Y, Nishina K, Mikawa K. et al. Lidocaine attenuates acute lung injury induced by a combination of phospholipase A2 and trypsin. Crit Care Med 2000; 28: 484-489
• 54 Flondor M, Listle H, Kemming GI. et al. Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats. Eur J Anaesthesiol 2010; 27: 53-60
• 55 Shiga M, Nishina K, Mikawa K. et al. The effects of lidocaine on nitric oxide production from an activated murine macrophage cell line. Anesth Analg 2001; 92: 128-133
• 56 Huang YH, Tsai PS, Kai YF. et al. Lidocaine inhibition of inducible nitric oxide synthase and cationic amino acid transporter-2 transcription in activated murine macrophages may involve voltage-sensitive Na+ channel. Anesth Analg 2006; 102: 1739-1744
• 57 Takaishi K, Kitahata H, Kawahito S. Local anesthetics inhibit nitric oxide production and L-arginine uptake in cultured bovine aortic endothelial cells. Eur J Pharmacol 2013; 704: 58-63
• 58 Piegeler T, Votta-Velis EG, Bakhshi FR. et al. Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-alpha-induced endothelial cell Src activation. Anesthesiology 2014; 120: 1414-1428
• 59 Paoli F, Darcourt G, Cossa P. Preliminary note on the action of imipramine in painful states. Rev Neurol 1960; 102: 503-504
• 60 Max MB, Culnane M, Schafer SC. et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37: 589-596
• 61 Mico JA, Ardid D, Berrocoso E. et al. Antidepressants and pain. Trends Pharmacol Sci 2006; 27: 348-354
• 62 Watson CP, Chipman M, Reed K. et al. Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. Pain 1992; 48: 29-36
• 63 Wagner K, Inceoglu B, Hammoc BD. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins Other Lipid Mediat 2011; 96: 76-83
• 64 Wagner K, Inceoglu B, Hammoc BD. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. J Agric Food Chem 2011; 59: 2816-2824
• 65 Morisseau C, Inceoglu B, Schmelzer K. et al. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res 2010; 51: 3481-3490
• 66 Inceoglu B, Jinks SL, Ulu A. et al. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci 2008; 105: 18901-18906
• 67 Terashvili M, Tseng LF, Wu HE. et al. Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. J Pharmacol Exp Ther 2008; 326: 614-622
• 68 Inceoglu B, Wagner KM, Yang J. et al. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci 2012; 109: 11390-11395
• 69 Guedes AG, Morisseau C, Sole A. et al. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Veterinary Anaesth Analg 2013; 40: 440-448
• 70 Jones E, Vinuela-Fernandez I, Eager RA. et al. Neuropathic changes in equine laminitis pain. Pain 2007; 132: 321-331
• 71 Green EM, Cooper RC. Continuous caudal epidural anesthesia in the horse. J Am Vet Med Assoc 1984; 184: 971-974
• 72 Martin CA, Kerr CL, Pearce SG. et al. Outcome of epidural catheterization for delivery of analgesics in horses: 43 cases (1998–2001). J Am Vet Med Assoc 2003; 222: 1394-1398
• 73 Natalini CC, Robinson EP. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am J Vet Res 2000; 61: 1579-1586
• 74 Robinson EP, Natalini CC. Epidural anesthesia and analgesia in horses. Vet Clin North Am Equine Pract 2002; 18: 61-82
• 75 Watkins AR, Hopster K, Levine D. et al. Cervical epidural catheter placement for pain management of forelimb superficial digital flexor muscle tear in a Quarter Horse gelding: case report. Frontiers Vet Sci 2021; 4: 749713
• 76 Hopster K, Watkins AR, Hurcombe SD. Comparison of cervical epidural morphine with intravenous morphine administration on antinociception in adult horses using thermal threshold testing. Vet Anaesth Analg 2022; 49: 417-422
• 77 Bromage PR, Bramwell RS, Catchlove RF. et al. Peridurography with metrizamide: animal and human studies. Radiology 1978; 128: 123-126
• 78 Hurcombe SD, Morris TB, VanderBroek AR. et al. Cervical Epidural and Subarachnoid Catheter Placement in Standing Adult Horses. Front Vet Sci 2020; 7: 232
• 79 Lerche P, Aarnes TK, Covey-Crump G. et al. Handbook of Small Animal Regional Anesthesia and Analgesia Techniques. Chichester, West Sussex, UK: John Wiley & Sons; 2016: 10-19
• 80 Lascelles BDX, Rausch-Derra LC, Wofford JA. et al. Pilot, randomized, placebo-controlled clinical field study to evaluate the effectiveness of bupivacaine liposome injectable suspension for the provision of post-surgical analgesia in dogs undergoing stifle surgery. BMC Vet Res 2016; 12: 168
• 81 McCracken MJ, Schumacher J, Doherty TJ. et al. Efficacy and duration of effect for liposomal bupivacaine when administered perineurally to the palmar digital nerves of horses. American Journal of Veterinary Research 2020; 81: 400-405
• 82 Driessen B, Scandella M, Zarucco L. Development of a technique for continuous perineural blockade of the palmar nerves in the distal equine thoracic limb. Vet Anaesth Analg 2008; 35: 432-448