Electrochemical C–H Functionalization of Cyclic Amines

Tian Feng; Siyi Wang; Youai Qiu

doi:10.1055/a-1828-1217

Synlett, Table of Contents

Synlett 2022; 33(16): 1582-1588
DOI: 10.1055/a-1828-1217

synpacts

Electrochemical C–H Functionalization of Cyclic Amines

Tian Feng

,

Siyi Wang

,

Youai Qiu ∗

Abstract

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Abstract

Functionalized cyclic amines are essential structural motifs in synthetic chemistry and pharmaceutical chemistry, and Shono-type oxidation is a well-developed electrochemical approach for the synthesis of α- amines. In sharp contrast, electrochemically driven direct β-C(sp³)–H functionalization of amines has been far proven elusive. Herein, we outline the recent advances in this field and highlight our group’s effort to achieve electrochemical β-C(sp³)–H functionalization assisted by ferrocene as molecular electrocatalyst under mild conditions.

1 Introduction

2 Case studies of α-Functionalization (Shono-Type Oxidation)

3 Electrochemical β-C(sp³)–H Acylation

4 Conclusion

Key words

β-acylation - Shono oxidation - electrochemistry - functionalized amines - selectivity - molecular electrocatalyst

Full Text

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