Download PDF
Zeitschrift für Orthomolekulare Medizin 2022; 20(02): 4-13
DOI: 10.1055/a-1817-8383
Wissen

Osteoporose – die unterschätzte und untertherapierte Volkskrankheit

Uwe Gröber
,
Hans-Peter Friedrichsen
,
Klaus Kisters
› Further Information
    Permissions and Reprints

Zusammenfassung

Osteoporose ist eine Skeletterkrankung, die durch ein Missverhältnis in der Aktivität der knochenauf- und -abbauenden Zellen, einer niedrigen Knochenmasse mit Verschlechterung der Mikroarchitektur des Knochengewebes gekennzeichnet ist. Sie manifestiert sich durch dünne Knochen mit einem hohen Risiko für Knochenbrüche. Zur Prävention und Therapie gehört neben einer kalziumreichen Ernährung und regelmäßiger körperlicher Aktivität auch eine adäquate Versorgung des Organismus mit einem komplexen Spektrum knochenrelevanter Mikronährstoffe.

Schlüsselwörter

Osteoporose - Knochen - knochengesunde Ernährung - Vitamin D - Kalzium - Bisphonate - Vitamin A - Vitamin K - Vitamin C - Vitamin B6 - B9 und B12 - Magnesium - Kalium - Zink - Mangan - Kupfer - Bor - ω-3-Fettsäuren - Aminosäuren


Publication History

Article published online:
23 June 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Bartl R.. Osteoporosis – risk factors and prevention program. Pharmakon 2019; 7: 250-257
    Google Scholar
  • 2 Bartl R.. Aktuelle Osteoporoseprophylaxe und -therapie. Frakturorientiert, effektiv, nebenwirkungsarm, kostengünstig. Internist 2015; 56: 1445-1457
    CrossrefPubMedGoogle Scholar
  • 3 Bartl R, Schöps P, Bartl C.. Osteoporosis – Pain relief first!. MMW Fortschr Med 2015; 157: 59-62
    PubMedGoogle Scholar
  • 4 Bartl R, Gradinger R.. Current diagnosis and therapy of osteoporosis on the basis of "European guidance 2008". Orthopäde 2009; 38: 365-379
    PubMedGoogle Scholar
  • 5 Rizzoli R, Stevenson JC, Bauer JM. et al. ESCEO Task Force. The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas 2014; 79: 122-132
    CrossrefPubMedGoogle Scholar
  • 6 Nowson C, O’Connell S.. Protein requirements and recommendations for older people: A review. Nutrients 2015; 7: 6874-6899
    CrossrefPubMedGoogle Scholar
  • 7 Cashman KD, Dowling KG, Skrabakova Z. et al. Vitamin D deficiency in Europe: pandemic?. Am J Clin Nutr 2016; 103: 1033-1044
    CrossrefPubMedGoogle Scholar
  • 8 Borsche L, Glauner B, von Mendel J.. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients 2021; 13: 3596
    CrossrefPubMedGoogle Scholar
  • 9 Bischoff-Ferrari HA, Willet WC, Orav EJ. et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367: 40-49
    CrossrefPubMedGoogle Scholar
  • 10 Liu C, Kuang X, Li K. et al. Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Food Funct 2020; 11: 10817-10827
    CrossrefPubMedGoogle Scholar
  • 11 Yao P, Bennett D, Mafham M. et al. Vitamin D and Calcium for the Prevention of Fracture. A Systematic Review and Meta-analysis. JAMA Netw Open 2019; 2: e1917789
    CrossrefPubMedGoogle Scholar
  • 12 DACH. Referenzwerte für die Nährstoffzufuhr – Vitamin D. Bonn, 2008
  • 13 Wacker M, Holick MF.. Vitamin D-Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 2013; 5: 111-148
    CrossrefPubMedGoogle Scholar
  • 14 Bruyere O, Reginster JY.. Vitamin D status and response to antiosteoporotic therapy. Womens Health 2008; 4: 445-447
    PubMedGoogle Scholar
  • 15 Adami S. et al. Vitamin D status and response to treatment in post-menopausal osteoporosis. Osteoporos Int 2009; 20: 239-244
    CrossrefPubMedGoogle Scholar
  • 16 Bedogni A, Saia G, Bettine G. et al. Osteomalacia: the missing link in the pathogenesis of bisphosphonate-related osteonecrosis of the jaws?. The Oncologist 2012; 17: 1114-1119
    CrossrefPubMedGoogle Scholar
  • 17 Favus MJ.. Bisphosphonates for osteoporosis. N Engl J Med 2010; 363: 2027-2035
    CrossrefPubMedGoogle Scholar
  • 18 Heaney RP.. Vitamin D in health and disease. Clin J Am Soc Nephrol 2008; 3: 1535-1541
    CrossrefPubMedGoogle Scholar
  • 19 Gröber U, Holick MF.. Vitamin D – die Heilkraft des Sonnenvitamins. 4., aktual. u. erw. Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft;; 2020
    Google Scholar
  • 20 Domarus C, Brown J, Barvencik F. et al. How Much Vitamin D Do We Need for Skeletal Health?. Clin Orthop Relat Res 2011; 469: 3127-3133
    CrossrefPubMedGoogle Scholar
  • 21 Henning P, Conaway HH, Lerner UH.. Retinoid receptors in bone and their role in bone remodelling. Front Endocrinol (Lausanne) 2015; 6: 31
    CrossrefPubMedGoogle Scholar
  • 22 Yee MMF, Chin KY, Ima-Nirwana S. et al. Vitamin A and Bone Health: A Review on Current Evidence. Molecules 2021; 26: 1757
    CrossrefPubMedGoogle Scholar
  • 23 Cancela ML, Price PA.. Retinoic acid induces matrix Gla protein gene expression in human cells. Endocrinology 1992; 130: 102-108
    CrossrefPubMedGoogle Scholar
  • 24 Jääskeläinen T, Ryhänen S, Mäenpää P.. 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells. J Cell Biochem 2003; 89: 1164-1176
    CrossrefPubMedGoogle Scholar
  • 25 Arbour NC, DeLuca HF. et al. Transcriptional control of the osteocalcin gene by 1,25-dihydroxyvitamin D-2 and its 24 epimer in rat osteosarcoma cells. Biochem Biophys Acta 1995; 1263: 147-153
    PubMedGoogle Scholar
  • 26 Gröber U, Kisters K.. Vitamin K – Ein altes Vitamin im neuen Licht. 4. Aufl.. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2021
    Google Scholar
  • 27 Knapen MH, Drummen NE, Smit E. et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 2013; 24: 2499-2507
    CrossrefPubMedGoogle Scholar
  • 28 Sato T, Inaba N, Yamashita T.. MK-7 and Its Effects on Bone Quality and Strength. Nutrients 2020; 12: 965
    CrossrefPubMedGoogle Scholar
  • 29 Gröber U, Kisters K.. Vitamin K in Prävention und Therapie. EHK 2016; 65: 184-191
    Article in Thieme ConnectGoogle Scholar
  • 30 Gröber U, Kisters K.. Vitamin D niemals ohne Vitamin K2 – Imperativ oder Konjunktiv?. EHK 2018; 67: 226-230
    Article in Thieme ConnectGoogle Scholar
  • 31 Hu L, Ji J, Li D. et al. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res 2021; 16: 592
    Google Scholar
  • 32 Sato Y, Honda Y, Iwamoto J. et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 2005; 293: 1082-1088
    CrossrefPubMedGoogle Scholar
  • 33 Sugiyama T, Tanaka H, Taguchi T.. Folate and vitamin B12 for hip fracture prevention after stroke. JAMA 2005; 294: 792
    CrossrefPubMedGoogle Scholar
  • 34 Saito M, Marumo K.. The Effects of Homocysteine on the Skeleton. Curr Osteoporos Rep 2018; 16: 554-560
    CrossrefPubMedGoogle Scholar
  • 35 Gröber U, Schmidt J, Kisters K.. Magnesium in Prevention and Therapy. Nutrients 2015; 7: 8199-8226
    CrossrefPubMedGoogle Scholar
  • 36 Barbagallo M, Veronese N, Dominguez LJ.. Magnesium in Aging, Health and Diseases. Nutrients 2021; 13: 463
    CrossrefPubMedGoogle Scholar
  • 37 Kisters K, Gröber U, Westhoff T. et al. Increased serum vitamin D concentration under oral magnesium therapy in elderly hypertensives. Magnes Res 2020; 33: 131-132
    CrossrefPubMedGoogle Scholar
  • 38 Capozzi A, Scambia G, Lello S.. Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health. Maturitas 2020; 140: 55-63
    CrossrefPubMedGoogle Scholar
  • 39 Granchi D, Torreggiani E, Massa A. et al. Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss. PLoS One 2017; 12: e0181230
    CrossrefPubMedGoogle Scholar
  • 40 Strause L, Saltman P, Smith KT.. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994; 124: 1060-1064
    CrossrefPubMedGoogle Scholar
  • 41 Gröber U, Kisters K.. Das Ultraspurenelement Bor. Zeitschr f Orthomol Med 2015; 4: 9-15
    Google Scholar
  • 42 Rozner R, Vernikov J, Griess-Fishheimer S. et al. The Role of Omega-3 Polyunsaturated Fatty Acids from Different Sources in Bone Development. Nutrients 2020; 12: 3494
    CrossrefPubMedGoogle Scholar
  • 43 Torricelli P, Fini M, Giavaresi G. et al. L-arginine and L-lysine stimulation on cultured human osteoblasts. Biomed Pharmacother 2002; 56: 492-497
    CrossrefPubMedGoogle Scholar
  • 44 Jennings A, MacGregor A, Spector T. et al. Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins. J Bone Miner Res 2016; 31: 326-335
    CrossrefPubMedGoogle Scholar
  • 45 Yang T, Lee SY, Park KC. et al. The Effects of Selenium on Bone Health: From Element to Therapeutics. Molecules 2022; 27: 392
    CrossrefPubMedGoogle Scholar