kleintier konkret 2022; 25(04): 34-44
DOI: 10.1055/a-1809-0602
Innere Medizin

Kanine Babesiose – Teil 1: Verbreitung, Übertragung, Symptome und Diagnostik

Catharina Cynthia Euler

Die kanine Babesiose ist eine an Bedeutung zunehmende Erkrankung, deren Erreger durch Zecken übertragen werden. Im folgenden Beitrag werden häufig auftretende Fragen über Verbreitung, Übertragungswege, Symptomatik und Diagnostik der kaninen Babesiose in Deutschland nach aktuellen Erkenntnissen beantwortet.



Publication History

Article published online:
17 August 2022

© 2022. Thieme. All rights reserved.

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  • Literatur

  • 1 El-Bahnasawy MM, Khalil HH, Morsy TA. Babesiosis in an Egyptian boy acquired from pet dog, and a general review. J Egypt Soc Parasitol 2011; 41 (01) 99-108
  • 2 Babes V. Sur lʼhemoglobinurie bactérienne du boeuf. C R Acad Sci Ser III Sci Vie 1888; 107: 692-694
  • 3 Roncalli AR. The history of Italian parasitology. Vet Parasitol 2001; 98: 3-30
  • 4 Jacobson LS, Clark IA. The pathophysiology of canine babesiosis: new approaches to an old puzzle. J S Afr Vet Assoc 1994; 65 (03) 134-145
  • 5 Welzl C, Leisewitz AL, Jacobson LS. et al. Systemic inflammatory response syndrome and multiple-organ damage/dysfunction in complicated canine babesiosis. J S Afr Vet Assoc 2001; 72 (03) 158-162
  • 6 Clark IA, Jacobson LS. Do babesiosis and malaria share a common disease process?. Ann Trop Med Parasitol 1998; 92 (04) 483-488
  • 7 Patton WS. Preliminary report on a new piroplasm (Piroplasma gibsoni sp. nov.) found in the blood of the hounds of the Madras Hunt and subsequently discovered in the blood of the jackal Canis aureus. Bull Soc Pathol Exot 1910; 3: 274-280
  • 8 Schnittger L, Rodriguez AE, Florin-Christensen M, Morrison DA. Babesia: a world emerging. Infect Genet Evol 2012; 12 (08) 1788-1809
  • 9 Lack JB, Reichard MV, Van Den Bussche RA. Phylogeny and evolution of the Piroplasmida as inferred from 18S rRNA sequences. Int J Parasitol 2012; 42 (04) 353-363
  • 10 Baneth G. Reclassification of Theileria annae as Babesia vulpes sp. nov. Parasit Vectors 2015; 8: 207
  • 11 Zahler M, Rinder H, Schein E, Gothe R. Detection of a new pathogenic Babesia microti-like species in dogs. Vet Parasitol 2000; 89: 241-248
  • 12 Kjemtrup AM, Wainwright K, Miller M. et al. Babesia conradae sp. nov., a small canine Babesia identified in California. Vet Parasitol 2006; 138: 103-111
  • 13 Birkenheuer AJ. Detection and molecular characterization of a novel large Babesia species in a dog. Vet Parasitol 2004; 124(3 – 4): 151-160
  • 14 Duh D, Tozon N, Petrovec M. et al. Canine babesiosis in Slovenia: molecular evidence of Babesia canis canis and Babesia canis vogeli. Vet Res 2004; 35 (03) 363-368
  • 15 Baneth G, Cardoso L, Brilhante-Simoes P, Schnittger L. Establishment of Babesia vulpes n. sp. (Apicomplexa: Babesiidae), a piroplasmid species pathogenic for domestic dogs. Parasit Vectors 2019; 12: 129
  • 16 Hartelt K, Pluta S, Oehme R, Kimmig P. Spread of ticks and tick-borne diseases in Germany due to global warming. Parasitol Res 2008; 103 (Suppl. 01) 109-116
  • 17 Najm NA, Meyer-Kayser E, Hoffmann L. et al. A molecular survey of Babesia spp. and Theileria spp. in red foxes (Vulpes vulpes) and their ticks from Thuringia, Germany. Ticks Tick Borne Dis 2014; 5 (04) 386-391
  • 18 Brandao LP, Hagiwara MK, Myiashiro SI. Humoral immunity and reinfection resistance in dogs experimentally inoculated with Babesia canis and either treated or untreated with imidocarb dipropionate. Vet Parasitol 2003; 114: 253-265
  • 19 Boozer L, Macintire D. Babesia gibsoni: An emerging pathogen in dogs. Compendium on Continuing Education for the Practising Veterinarian–North American Edition 2005; 27 (01) 33-42
  • 20 Jefferies R, Ryan UM, Jardine J. et al. Blood, Bull Terriers and Babesiosis: further evidence for direct transmission of Babesia gibsoni in dogs. Aust Vet J 2007; 85: 459-463
  • 21 Jeagley TJ, Reichard MV, Hempstead JE. et al. Detection of Babesia gibsoni and the canine small Babesia ‚Spanish isolate‘ in blood samples obtained from dogs confiscated from dogfighting operations. J Am Vet Med Assoc 2009; 235: 535-539
  • 22 Birkenheuer AJ, Correa MT, Levy MG, Breitschwerdt EB. Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000–2003). J Am Vet Med Assoc 2005; 227: 942-947
  • 23 Birkenheuer AJ, Levy MG, Stebbins M. et al. Serosurvey of anti Babesia antibodies in stray dogs and American pit bull terriers and American staffordshire terriers from North Carolina. J Am Anim Hosp Assoc 2003; 39: 551-557
  • 24 Trotta M, Carli E, Novari G. et al. Clinicopathological findings, molecular detection and characterization of Babesia gibsoni infection in a sick dog from Italy. Vet Parasitol 2009; 165: 318-322
  • 25 Irwin PJ. Canine babesiosis: from molecular taxonomy to control. Parasit Vectors 2009; Suppl 1 (Suppl 1): S4
  • 26 Ayoob AL, Hackner SG, Prittie J. Clinical management of canine babesiosis. J Vet Emerg Crit Care (San Antonio) 2010; 20 (01) 77-89
  • 27 Mierzejewska EJ, Welc-Faleciak R, Bednarska M. et al. The first evidence for vertical transmission of Babesia canis in a litter of Central Asian Shepherd dogs. Ann Agric Environ Med 2014; 21 (03) 500-503
  • 28 Fukumoto S, Suzuki H, Igarashi I, Xuan X. Fatal experimental transplacental Babesia gibsoni infections in dogs. Int J Parasitol 2005; 35: 1031-1035
  • 29 Eckert J, Friedhoff KT, Zahner H, Deplazes P. Lehrbuch der Parasitologie für die Tiermedizin. Stuttgart: Enke; 2005: 57
  • 30 Barutzki D, Reule M, Scheunemann R. et al. Die Babesiose des Hundes. Dt Tierärztebl 2007; 55: 284-293
  • 31 Zahler M, Rinder H, Schein E, Gothe R. Detection of a new pathogenic Babesia microti-like species in dogs. Vet Parasitol 2000; 89 (03) 241-248
  • 32 Zahler M, Rinder H, Zweygarth E. et al. Babesia gibsoni of dogs from North America and Asia belong to different species. Parasitol 2000; 120 (04) 365-369
  • 33 Beck R, Vojta L, Mrljak V. et al. Diversity of Babesia and Theileria species in symptomatic and asymptomatic dogs in Croatia. Int J Parasitol 2009; 39 (07) 843-848
  • 34 Falkenö U, Tasker S, Osterman-Lind E, Tvedten HW. Theileria annae in a young Swedish dog. Acta Vet Scand 2013; 55: 50
  • 35 Hinaidy HK, Tschepper P. Babesia canis in a dog in Austria. Wien Tierärztl Mschr 1979; 66: 302-304
  • 36 Schwendenwein I. Canine babesiosis in Austria – review of clinical presentation, diagnosis and therapy with reference to four cases. Wien Tierärztl Mschr 1989; 76: 161-164
  • 37 Daugschies A. Import von Parasiten durch Tourismus und Tierhandel. Dtsch tierärztl Wschr 2001; 108: 348-352
  • 38 Heile C, Heydorn AO, Schein E. Dermacentor reticulatus (Fabricius, 1794) – Verbreitung, Biologie und Vektor von Babesia canis in Deutschland. Berl Münch Tierarztl Wochenschr 2006; 119(7 – 8): 330-334
  • 39 Janjić F, Sarvan D, Tomanović S. et al. A short-term and long-term relationship between occurrence of acute canine babesiosis and meteorological parameters in Belgrade, Serbia. Ticks Tick Borne Dis 2019; 10: 101273
  • 40 Deplazes P, Eckert J, von Samson-Himmelstjerna G, Zahner H. Lehrbuch der Parasitologie für die Tiermedizin. 3. Aufl.. Stuttgart: Enke; 2013
  • 41 Deplazes P, Staebler S, Gottstein B. Reisemedizin parasitärer Erkrankungen des Hundes. Schweiz Arch Tierheilk 2006; 148: 447-461
  • 42 Belton D. Import risk analysis: Babesia gibsoni in dogs (Canis familiaris) and dog semen. Wellington (NZ): Biosecurity Authority, MAF 2003.
  • 43 Karbowiak G. The occurrence of the Dermacentor reticulatus tick-its expansion to new areas and possible causes. Ann Parasitol 2014; 60 (01) 37-47
  • 44 Mehlhorn H. Light and electron microscopic study on developmental stages of Babesia canis within the gut of the tick Dermacentor reticulatus. J Parasitol 1980; 66 (02) 220-228
  • 45 Martinod S, Brossard M, Moreau Y. Immunity of dogs against Babesia canis, its vector tick Dermacentor reticulatus, and Ixodes ricinus in endemic area. J Parasitol 1985; 71: 269-273
  • 46 Uilenberg G. Babesia – a historical overview. Vet Parasitol 2006; 138(1 – 2): 3-10
  • 47 Rubel F, Brugger K, Monazahian M. et al. The first German map of georeferenced ixodid tick locations. Parasit Vectors 2014; 7: 477
  • 48 Hartelt K, Rieker T, Oehme RM. et al. First evidence of Babesia gibsoni (Asian genotype) in dogs in Western Europe. Vector Borne Zoonotic Dis 2007; 7: 163-166
  • 49 Teodorowski O, Kalinowski M, Winiarczyk D. et al. Babesia gibsoni Infection in Dogs – A European Perspective. Animals 2022; 12 (06) 730
  • 50 Chao LL, Liao HT, Ho TY, Shih CM. First detection and molecular identification of Babesia gibsoni from Rhipicephalus sanguineus ticks. Acta Trop 2017; 166: 356-362
  • 51 Homer MJ, Aguilar-Delfin I, Telford SR. et al. Babesiosis. Clin Microbiol Rev 2000; 13: 451-469
  • 52 Yabsley MJ, Shock BC. Natural history of Zoonotic Babesia: Role of wildlife reservoirs. Intern J Parasitol Parasit Wild 2013; 2: 18-31
  • 53 Kjemtrup AM, Conrad PA. Human babesiosis: an emerging tick-borne disease. Int J Parasitol 2000; 30: 1323-1337
  • 54 Mellanby RJ, Handel IG, Clements DN. et al. Breed and sex risk factors for canine babesiosis in South Africa. J Vet Intern Med 2011; 25: 1186-1189
  • 55 Hornok S, Edelhofer R, Farkas R. Seroprevalence of canine babesiosis in Hungary suggesting breed predisposition. Parasitol Res 2006; 99: 638-642
  • 56 Martinod S, Brossard M, Moreau Y. Immunity of dogs against Babesia canis, its vector tick Dermacentor reticulatus, and Ixodes ricinus in endemic area. J Parasitol 1985; 71 (03) 269-273
  • 57 Kraje AC. Canine haemobartonellosis and babesiosis. Compend Contin Educ 2001; 23: 310-318
  • 58 Solano-Gallego L, Capri A, Pennisi MG. et al. Acute febrile illness is associated with Rickettsia spp infection in dogs. Parasit Vectors 2015; 8: 216
  • 59 Eichenberger RM, Riond B, Willi B. et al. Prognostic markers in acute Babesia canis infections. J Vet Intern Med 2016; 30: 174-182
  • 60 Matijatko V, Torti M, Schetters TP. Canine babesiosis in Europe: how many diseases?. Trends Parasitol 2012; 28 (03) 99-105
  • 61 Milanović Z, Vekić J, Radonjić V. et al. Association of acute Babesia canis infection and serum lipid lipoprotein, and apoprotein concentrations in dogs. J Vet Intern Med 2019; 33: 1686-1694
  • 62 Schetters TP, Kleuskens JA, Van De Crommert J. et al. Systemic infl ammatory responses in dogs experimentally infected with Babesia canis; a haematological study. Vet Parasitol 2009; 162: 7-15
  • 63 Birkenheuer AJ, Levy MG, Breitschwerdt EB. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs. J Vet Intern Med 2004; 18: 494-498
  • 64 Miro G, Checa R, Paparini A. et al. Theileria annae (syn. Babesia microti-like) infection in dogs in NW Spain detected using direct and indirect diagnostic techniques: clinical report of 75 cases. Parasit Vectors 2015; 8: 217
  • 65 Vannier EG, Diuk-Wasser MA, Mamoun CB, Krause PJ. Babesiosis. Infect Dis Clin North Am 2015; 29: 357-370
  • 66 Solano-Gallego L, Baneth G. Babesiosis in dogs and cats – expanding parasitological and clinical spectra. Vet Parasitol 2011; 181: 48-60
  • 67 Solano-Gallego L, Trotta M, Carli E. et al. Babesia canis canis and Babesia canis vogeli clinicopathological findings and detection by means of PCR-RFLP in blood from Italian dogs suspected of tick-borne disease. Vet Parasitol 2008; 157: 211-221
  • 68 Zygner W, Gójska-Zygner O, Bąska P, Długosz E. Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis. Parasitol Res 2014; 113 (04) 1499-1503
  • 69 Zygner W, Gójska-Zygner O. Increased serum urea to creatinine ratio and its negative correlation with arterial pressure in canine babesiosis. Acta Parasitol 2014; 59 (03) 548-551
  • 70 Bohm M, Leisewitz AL, Thompson PN, Schoeman JP. Capillary and venous Babesia canis rossi parasitaemias and their association with outcome of infection and circulatory compromise. Vet Parasitol 2006; 141: 18-29
  • 71 Ogo N, Okubanjo O, Kamani J. Current Status of Canine Babesiosis and the Situation in Nigeria: A Review. Nigerian Vet J 2011; 32 (02) 69-78
  • 72 Globokar Vrhovec M. Retrospektive Analyse der parasitologischen Untersuchungs-ergebnisse eines privaten Untersuchungslabors: Intestinale, respiratorische und vektorübertragene Parasitosen bei Hunden und Katzen in Deutschland (2004 – 2006) [Dissertation]. Giessen: Justus-Liebig-Universität Giessen; 2013
  • 73 Jongejan F, Fourie JJ, Chester ST. et al. The prevention of transmission of Babesia canis canis by Dermacentor reticulatus ticks to dogs using a novel combination of fipronil, amitraz and (S)-methoprene. Vet Parasitol 2011; 179: 343-350
  • 74 Adaszek Ł, Banach T, Bartnicki M. et al. Application the mass spectrometry MALDI-TOF technique for detection of Babesia canis canis infection in dogs. Parasitol Res 2014; 113 (11) 4293-4295
  • 75 Sainz A, Roura X, Miro G. et al. Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasit Vectors 2015; 8: 75
  • 76 Vercammen F, De Deken R, Maes L. Clinical and serological observations on experimental infections with Babesia canis and its diagnosis using the IFAT. Parasite 1995; 2: 407-410
  • 77 Fukumoto S, Sekine Y, Xuan X. et al. Serodiagnosis of canine Babesia gibsoni infection by enzyme-linked immunosorbent assay with recombinant P50 expressed in Escherichia coli. J Parasitol 2004; 90: 387-391
  • 78 Uilenberg G, Franssen FF, Perie NM, Spanjer AA. Three groups of Babesia canis distinguished and a proposal for nomenclature. Vet Q 1989; 11: 33-40
  • 79 Yamane I, Thomford JW, Gardner IA. et al. Evaluation of the indirect fluorescent antibody test for diagnosis of Babesia gibsoni infections in dogs. Am J Vet Res 1993; 54: 1579-1584
  • 80 Kovačević Filipović MM, Beletić AD, Ilić Božović AV. et al. Molecular and serological prevalence of Anaplasma phagocytophilum, A. platys, Ehrlichia canis, E. chaffeensis, E. ewingii, Borrelia burgdorferi, Babesia canis, B. gibsoni and B. vogeli among among Clinically Healthy Outdoor Dogs in Serbia. Vet Parasitol Reg Stud Reports 2018; 14: 117-122
  • 81 Maggi RG, Birkenheuer AJ, Hegarty BC. et al. Comparison of serological and molecular panels for diagnosis of vector-borne diseases in dogs. Parasit Vectors 2014; 7: 127
  • 82 Conrad P, Thomford J, Yamane I. et al. Hemolytic anemia caused by Babesia gibsoni infection in dogs. J Am Vet Med Assoc 1991; 199: 601-605