SIRT: Planung, Durchführung, Dosimetrie

Zusammenfassung

Die Selektive Interne Radiotherapie (SIRT) ist ein nuklearmedizinisches Therapieverfahren zur Behandlung von Tumoren und Metastasen in der Leber. Dabei werden radioaktiv markierte Mikrosphären gezielt über einen Katheter in die Leberarterie injiziert, welche sich anschließend im Tumorgewebe anreichern. Dieser Übersichtsartikel soll einen Überblick zur allgemeinen Planung und Durchführung der Therapie sowie den derzeitig verfügbaren Mikrosphären geben. Des Weiteren werden die unterschiedlichen Methoden zur Ermittlung der Therapieaktivität unter Berücksichtigung der aktuellen Empfehlungen und Leitlinien der European Association of Nuclear Medicine (EANM) genauer erläutert. Dabei wird der Stellenwert einer personalisierten Dosimetrie diskutiert.

Abstract

Selective Internal Radiotherapy (SIRT) is a nuclear medicine therapy procedure for the treatment of tumours and metastases in the liver. Radioactively-labelled microspheres are injected into the hepatic artery via a catheter, where they subsequently accumulate in the tumour tissue. This review aims to provide an overview of the general treatment planning and therapy procedures as well as currently available microspheres. Furthermore, the different methods for determining the therapy activity are explained in more detail, taking into account the current recommendations and guidelines of the European Association of Nuclear Medicine (EANM). The importance of personalised dosimetry is discussed.

Schlüsselwörter

SIRT - Radioembolisation - Dosimetrie - ⁹⁰Y - ¹⁶⁶Ho - Mikrosphären

Keywords

SIRT - Radioembolization - Dosimetry - ⁹⁰Y - ¹⁶⁶Ho - Microspheres

Publication History

Article published online:
21 March 2023

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