Comorbidities in Children with COVID-19 and MIS-C/PIMS-TS and
                    Risk Factors for Hospitalization, Severe Disease, Intensive Care and
                    Death

Tobias Ankermann; Folke Brinkmann

doi:10.1055/a-1727-5895

Klin Padiatr 2022; 234(05): 257-266
DOI: 10.1055/a-1727-5895

Review

Comorbidities in Children with COVID-19 and MIS-C/PIMS-TS and Risk Factors for Hospitalization, Severe Disease, Intensive Care and Death

Komorbidität bei Kindern mit COVID-19 und MIS-C/PIMS-TS und Risikofaktoren für Hospitalisierung, schweren Krankheitsverlauf, Intensivtherapie und Tod

Tobias Ankermann

¹Klinik für Kinder- und Jugendmedizin, Städtisches Krankenhaus Kiel, Kiel, Germany

,

Folke Brinkmann

²Abteilung Pädiatrische Pneumologie, Allergologie und CF-Zentrum, Universitätskinderklinik Bochum, Bochum, Germany

› Author Affiliations

Abstract

This narrative review sums up data from the SARS-CoV-2-pandemia on preexisting disease/underlying conditions/comorbidities and risk factors in children for severe COVID-19 and MIS-C/PIMS-TS as well as hospitalization and mortality. Young infants and adolescents are at highest risk of hospital and PICU admission. Two or more comorbidities rather than single entities pose a risk for more severe courses of SARS-CoV-2 infection in children. Asthma and malignancy do not increase complication rates. MIS-C/PIMS-TS is not associated with any specific underlying disease.

Zusammenfassung

Der narrative Review fasst vorliegende Daten zu zugrundeliegenden Erkrankungen und Komorbiditäten und Risikofaktoren für schweren Verlauf von COVID-19 und MIS-C/PIMS-TS bei Kindern, erfasst als Hospitalisierung, Aufnahme auf einer Intensivstation und Tod bei Kindern, zusammen. Säuglinge und Jugendliche haben das höchste Risiko für Hospitalisierungen und Aufnahme auf einer Intensivstation. Mehr als eine Grunderkrankung/Komorbidität erhöht das Risiko für einen schweren Verlauf einer SARS-CoV-2-Infektion bei Kindern. In den vorliegenden Daten findet sich keine Assoziation eines schweren Verlaufes mit Asthma bronchiale und onkologischen Erkrankungen. Es findet sich keine Assoziation von Grunderkrankungen und Komorbiditäten mit MIS-C/PIMS-TS.

Key words

COVID-19 - MIS-C/PIMS-TS - children - severe disease - risk faktor - underlying disease

Schlüsselwörter

COVID-19 - MIS-C/PIMS-TS - Kinder - schwere Erkrankung - Risikofaktoren - Grunderkrankungpublished online 2022

Full Text

References

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