Klin Padiatr 2022; 234(05): 305-308
DOI: 10.1055/a-1717-2234
Short Communication

Mepolizumab Treatment in Severe Pediatric Asthma: First Multicentric Real-World Data

Mepolizumab bei pädiatrischem schwerem Asthma: erste multizentrische Daten aus der Praxis
Martin Wetzke
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Frank O. Ahrens
2   Pediatrics, AKK Altona Children's Hospital, Hamburg, Germany
,
Monika Gappa
3   Pediatrics, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany
,
Gesine Hansen
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Cordula Koerner-Rettberg
4   Pediatrics, Children’s Hospital Wesel, Wesel, Germany
,
Holger Koester
5   Pediatrics, Oldenburg Hospital University Department Pediatrics and Adolescent Medicine, Oldenburg, Germany
,
Johannes Schulze
6   Pediatric Pneumology, Hospital of the Goethe University Frankfurt Centre for Paediatrics and Adolescent Medicine, Frankfurt am Main, Germany
,
Nicolaus Schwerk
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Stefan Zielen
6   Pediatric Pneumology, Hospital of the Goethe University Frankfurt Centre for Paediatrics and Adolescent Medicine, Frankfurt am Main, Germany
,
Christine Happle
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
7   Biomedical Research in Endstage and Obstruktive Lung Disease Hannover BREATH, German Center for Lung Research, Hannover, Germany
8   Excellence Cluster Infection Research RESIST, Hannover, Germany
› Author Affiliations

Introduction

Asthma is associated with high morbidity and healthcare costs around the globe. Severe asthma in children is rare, and treatment with biologicals is seldom prescribed in pediatric asthma (Santos-Valente E., ERJ Open Res. 2021 Aug 16;7(3):00143-2021). Although global guidelines recommend using biologicals in severely asthmatic children, knowledge on real-life application in pediatrics is scarce. To change this situation, we aimed to analyze application and effect of anti-IL5 (Mepolizumab) therapy in childhood asthma in six pediatric centers in Germany.



Publication History

Article published online:
22 March 2022

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