Theranostische Liganden: Aktuelle und zukünftige Anwendungen

Zusammenfassung

Theranostische Liganden sind niedermolekulare oder Träger-gebundene Radiopharmaka, die sowohl in der bildgebenden Diagnostik als auch in der Radionuklidtherapie überwiegend zur Behandlung verschiedener Tumorentitäten eingesetzt werden.

Eine Vielzahl theranostischer Radiopharmaka, wie bspw. ¹⁷⁷Lu-DOTATATE für die Peptid-Radiorezeptor-Therapie (PRRT), werden bereits erfolgreich klinisch eingesetzt. Weitere Liganden werden in Zukunft Einzug in die klinische Routine halten und möglicherweise neue therapeutische Optionen für Patienten mit Tumorerkrankungen bieten.

Ziel dieses Übersichtsartikels ist es, die Wertigkeit der theranostischen Liganden als Behandlungsmöglichkeit bei Patienten mit fortgeschrittenen Tumorerkrankungen darzustellen. Des Weiteren soll ein Überblick über zukünftige therapeutische Anwendungsmöglichkeiten verschiedener neuer Liganden und Radioisotope gegeben werden.

Abstract

Radiotheranostics are small-molecule or carrier-bound radiopharmaceuticals that can be used for diagnostic imaging and radionuclide therapy, especially for the treatment of various tumour diseases.

Several theranostic ligands, including ¹⁷⁷Lu-DOTATATE for peptide radioreceptor therapy (PRRT) were successfully translated to the clinic. Novel ligands are expected to enter clinical routine in the near future and may offer new therapeutic options for patients with cancer.

We aim to review the current and future value of radiotheranostics as management option for patients with advanced cancer. Furthermore, an overview of future therapeutic applications of novel ligands and radioisotopes will be given.

Schlüsselwörter

theranostische Liganden - PRRT - ¹⁷⁷Lu-DOTATATE - ¹⁷⁷Lu-PSMA

Key words

radiotheranostics - PRRT - ¹⁷⁷Lu-DOTATATE - ¹⁷⁷Lu-PSMA

Publication History

Article published online:
29 November 2021

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