Correction: Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level

Horm Metab Res. DOI: 10.1055/a-0855-7128 In the above-mentioned article ▶Fig. 1 was incorrect. ▶Fig. 1 is replaced by the flow chart below, which clarifies the numbers associated with each exclusion criterion.

Fig. 1 Flow chart of the study design.

In the above-mentioned article Table 1 displayed 2 incorrect data. Correct is: TSH Median (Min-Max) (mlU/l) for Pregnant women (n = 185) is 1.50 (0.03–5.30) mIU/l, and 10th percentile of FT4 for Pregnant women (n = 185) is 11.58.

Table 1 Participants’ basic characteristics and thyroid hormone levels.

Variables	Pregnant women (n=185)	Non-pregnant women (n=256)	p-Value
Age (years)*	28.7±5.11	29. 3±4. 87	0.212
TSH Median (2.5th–97.5th) (mIU/l)**
Age<25 years	1.6 (0.3–4.1)	1.9 (0.71–5.8)
Age 25–29.99 years	1.35 (0.2–4.6)	2.1 (0.6–7.8)
Age 30–34.99 years	1.6 (0.13–5.22)	1.95 (0.5–4.8)
Age ≥35 years	1.5 (0.2–4.9)	2.1 (0.8–4.5)
Gestational age (week/day)*	9.6±2.6	–
Gestational age (week/day)**	10w/3d (5w–14w/1d)
Urinary iodine concentration (Min-Max) (mg/l)***	209.0 (150–549)	194.0 (100–533 (	0.135
Thyroid volume (ml)*	6.±2.5*	6.4±2.1*	0.245
TSH Median (Min-Max) (mIU/l)***	1.50 (0.03–5.30)	2.10 (0.5–9.7)	0.001
2.5th percentile of TSH	0.20	0.59
5th percentile of TSH	0.40	0.80
10th percentile of TSH	0.60	1.00
90th percentile of TSH	2.85	3.80
95th percentile of TSH	4.10	4.30
97.5th percentile of TSH	4.60	5.60
FT4 Median (Min-Max) (pmol/l)***	12.87 (9.0–22.65)	14.15 (9.0–27.02)	0.001
2.5th percentile of FT4	9.0	9.52
5th percentile of FT4	10.30	10.30
10th percentile of FT4	11.58	11.60
90th percentile of FT4	15.44	18.01
95th percentile of FT4	16.73	18.01
97.5th percentile of FT4	18.02	19.30
FT3 Median (Min-Max) (pmol/l)***	4.40 (2.50–6.90)	4.50 (2.70–7.50)	0.356
2.5th percentile of FT3	3.40	3.70
5th percentile of FT3	3.53	3.80
10th percentile of FT3	3.80	3.90
90th percentile of FT3	5.10	5.10
95th percentile of FT3	5.27	5.20
97.5th percentile of FT3	5.64	5.55

* Data is presented as mean±SD; ^** Median (2.5th–97.5th); ^*** Median (Min-Max).

In the above-mentioned article ▶Table 2 excluded outlier values. Correction: ▶Table 2 is replaced with the revised table below. The group of non-pregnant women with positive TPOAb included 96 cases. However, 2 of these had outlier values for TSH concentrations, and therefore had been excluded from the data analysis presented in ▶Table 2 of the original paper. We omitted to mention this exclusion. Since exclusion of outlier data is controversial, we have taken this opportunity to not exclude these 2 outliers in the analysis; the modified results are shown in the revised ▶Table 2. It is worth noting that the P values for comparison of the medians showed no changes and the discussion of the paper remains valid; no correction is required in the main text.

Table 2 Median and 2.5^th and 97.5^th percentiles of thyroid function test values for participants with positive and negative thyroid peroxidase antibody (TPOAb) in both groups of pregnant and non-pregnant women, including women with and without iodine deficiency.

Variable	Pregnant women		P value	Non-pregnant women		P value
	TPOAb-positive (n=75)	TPOAb-negative (n=343)		TPOAb-positive (n=96)	TPOAb-negative (n=343)
TSH
Median (min–max) mIU/l	1.70 (0.001–9.80)	1.50 (0.01–7.10)	0.049	3.05 (0.006–113)	2.10 (0.008–10.70)	0.001
2.5th percentile	0.09	0.20		0.24	0.50
97.5th percentile	8.81	4.65		23.54	5.74
FT4
Median (min–max) pmol/l	12.8(9.009–28.31)	12.78 (9.009–22.56)	0.03	14.16 (5.15–24.50)	14.16 (9.009–33.50)	0.069
2.5th percentile	9.009	9.009		7.46	10.30
97.5th percentile	19.303	16.73		18.14	19.30
FT3
Median (min–max) pmol/l	4.50 (3.50–10.50)	4.50 (2.30–6.90)	0.232	4.40 (2.20–7.70)	4.50 (2.70–9.80)	0.023
2.5th percentile	3.59	3.46		3.00	3.70
97.5th percentile	6.18	5.90		5.25	5.54

To further clarify the results in ▶Table 2, we added the number of participants in each group whose data were analysed. In the above-mentioned article Table 3 displayed incorrect data. Table 3 has been replaced by ▶Table 3.1 and ▶3.2. The text in the section “Results” referring to the table has been changed accordingly.

Table 3.1 The serum TSH concentrations and multiples of the median (MoM) values at various percentiles in pregnant women (n = 418), and in the healthy pregnant women (TPOAb-negative and urinary iodine concentration [UIC] > 150 μg/l; n = 185) whose data were used to determine the reference range.

Percentile	Pregnant group ** (n=418)		Healthy pregnant group (n=185)
	TSH(mIU/l)	MoM TSH	TSH(mIU/l)	MoM TSH
1st	0.04	0.026	0.081	0.05
2nd*	–	–	–	–
2.5th	0.20	0.133	0.20	0.133
5th	0.30	0.20	0.40	0.266
10th	0.50	0.33	0.60	0.40
50th	1.50	1.00	1.50	1
90th	3.40	2.26	2.85	1.89
95th	4.41	2.93	4.10	2.73
97.5th	5.10	3.40	4.60	3.06
98th	5.55	3.70	4.68	3.12
99th	6.91	4.61	5.13	3.14

Table 3.2 The serum FT₄ concentrations and multiples of the median (MoM) values at various percentiles, in pregnant women (n=418), and in healthy pregnant women (TPOAb-negative and urinary iodine concentration [UIC] >150 µg/l; n=185) whose data were used to determine the reference range.

Percentile	Pregnant group ** (n=418)		Healthy pregnant group (n=185)
	FT4 (pmol/l)	MoM FT4	FT4 (pmol/l)	MoM FT4
1st*	–	–	–	–
2nd*	–	–	–	–
2.5th	9.00	0.70	9.00	0.70
5th*	–	–	10.30	0.80
10th	10.30	0.80	11.58	0.90
50th	12.87	1.00	12.87	1.00
90th	15.44	1.20	15.44	1.20
95th*	–	–	16.73	1.30
97.5th*	16.73	1.30	–	–
98th*	–	–	18.02	1.40
99th	18.02	1.40	18.66	1.45

10.1055/a-0855-7128

Publication History

Article published online:
12 August 2021