Einfluss der mediterranen Ernährung auf das Brustkrebsrisiko: Welche Rolle spielt das Mikrobiom?

Zusammenfassung

Zahlreiche Studien haben gezeigt, dass die mediterrane Ernährung vor ernährungsmitbedingten Erkrankungen wie Übergewicht, Diabetes mellitus Typ 2, Herz-Kreislauf-Erkrankungen und verschiedenen Krebsentitäten, einschließlich Brustkrebs, schützen kann. Die zugrunde liegenden Mechanismen sind jedoch weitgehend unklar. Bislang wurde vor allem die Rolle antiinflammatorischer Fettsäuren diskutiert. In der vorliegenden Übersichtsarbeit soll am Beispiel des genetisch determinierten sowie des sporadischen Brustkrebses der Frage nachgegangen werden, welche Rolle das Darmmikrobiom spielen könnte, dessen Zusammensetzung und Funktion durch die mediterrane Ernährung verändert wird.

Abstract

Numerous studies have shown that the Mediterranean diet can protect against diet-related diseases such as obesity, type 2 diabetes mellitus, cardiovascular diseases, and various cancer entities, including breast cancer. However, the underlying mechanisms are largely unclear. So far, mainly the role of anti-inflammatory fatty acids has been discussed. In the present review, using the example of genetically determined and sporadic breast cancer, the question will be addressed, what role the gut microbiome plays, since it’s composition and function is modulated by the Mediterranean diet.

Schlüsselwörter

mediterrane Ernährung - Brustkrebs - intestinale Mikrobiota

Keywords

Mediterranean diet - breast cancer - intestinal microbiota

^* Diese Autoren haben zu gleichen Teilen zu der Arbeit beigetragen.

Publication History

Article published online:
08 December 2021

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