Benigne und maligne Bindehauttumoren in Diagnostik und Therapie

Zusammenfassung

Bindehauttumoren betreffen in Diagnostik und Therapie alle Bereiche der augenärztlichen Praxis. Das beginnt mit der klinischen Kontrolle von Bindehautnävi und anderen benignen Tumoren, der Einschätzung von entzündlichen Pseudotumoren und ihrer Abgrenzung zu Präkanzerosen oder vernarbenden Erkrankungen und mündet in der hochspezialisierten und interdisziplinären Führung onkologischer Patienten mit Lymphomen, hochmalignen Melanomen oder invasiven Plattenepithelkarzinomen.

Publication History

Article published online:
30 April 2021

• Literatur

• 1 Freyler H. Bindehaut. In: Freyler H. Hrsg. Augenheilkunde. Wien: Springer; 1985: 103-130
• 2 Shields CL, Alset AE, Boal NS. et al Conjunctival tumors in 5002 cases. Comparative Analysis of benign versus malignant counterparts. The 2016 James D. Allen Lecture. Am J Ophthalmol 2017; 173: 106-133
• 3 Kao A, Afshar A, Bloomer M. et al Management of primary acquired melanosis, nevus, and conjunctival melanoma. Cancer Control 2016; 23: 117-125
• 4 Liu KC, Mruthyunjaya P, Proia AD. et al Pediatric conjunctival melanoma arising from a compound nevus. J AAPOS 2017; 21: 416-418
• 5 Shields CL, Fasiudden A, Mashayekhi A. et al. Conjunctival nevi: clinical features, and natural course in 410 consecutive patients. Arch Ophthalmol 2004; 122: 167-175
• 6 Theotoka D, Morkin MI, Galor A. et al Update on diagnosis and management of conjunctival papilloma. Eye Vis (Lond) 2019; 6: 18
• 7 Zimmermann-Paiz MA, Garcia de la Riva JC. Conjunctival tumors in children: histopathologic diagnosis in 165 cases. Arq Bras Oftalmol 2015; 78: 337-339
• 8 Mlakar J, Kocjan BJ, Hosnjak L. et al Morphological characteristics of conjunctival squamous papillomas in relation to human papillomavirus infection. Br J Ophthalmol 2015; 99: 431-436
• 9 Mukherjee B, Moosa S, Rajagopal R. Cavernous hemangioma of the conjunctiva. Indian J Ophthalmol 2019; 67: 2061
• 10 Theiler M, Baselga E, Gerth-Kahlert C. et al Infantile hemangiomas with conjunctival involvement: An underreported occurrence. Pediatr Dermatol 2017; 34: 681-685
• 11 Mansour AM, Barber JC, Reinecke RD. et al Ocular choristomas. Surv Ophthalmol 1989; 33: 339-358
• 12 Shields CL, Shields JA. Tumors of the conjunctiva and cornea. Surv Ophthalmol 2004; 49: 3-24
• 13 Jeong J, Song YJ, Jung SI. et al New surgical approach for limbal dermoids in children: simple excision, corneal tattooing, and sutureless limboconjunctival autograft. Cornea 2015; 34: 720-723
• 14 Pirouzian A. Management of pediatric corneal limbal dermoids. Clin Ophthalmol 2013; 7: 607-614
• 15 Schmitzer S, Burcel M, Dascalescu D. et al. Goldenhar Syndrome – ophthalmologistʼs perspective. Rom J Ophthalmol 2018; 62: 96-104
• 16 Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology 2004; 111: 997-1008
• 17 Stacy R, Jakobiec F, Schoenfield L. et al. Unifocal and multifocal reactive lymphoid hyperplasia vs. follicular lymphoma of the ocular adnexa. Am J Ophthalmol 2010; 150: 412-426
• 18 Klavdianou O, Kondylis G, Georgopoulos V. et al Bilateral benign reactive lymphoid hyperplasia of the conjunctiva: a case treated with oral doxycycline and review of the literature. Eye Vis (Lond) 2019; 6: 26
• 19 Coupland SE. Ocular adnexal lymphoid tumors: progress in need of clarification. Am J Ophthalmol 2008; 146: 791-792
• 20 Folberg R, McLean I, Zimmerman L. Conjunctival melanosis and melanoma. Ophthalmology 1984; 91: 673-678
• 21 Shields J, Shields C, Mashayekhi A. et al. Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture. Ophthalmology 2008; 115: 511-519
• 22 Damato B, Coupland S. Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging. Clin Experiment Ophthalmol 2008; 36: 786-795
• 23 Jain P, Finger PT, Damato B. et al. Multicenter, International assessment of the eighth edition of the American Joint Committee on Cancer Cancer Staging Manual for Conjunctival Melanoma. JAMA Ophthalmol 2019;
• 24 Seregard S, Kock E. Conjunctival malignant melanoma in Sweden 1969-1991. Acta Ophthalmol Scand 1992; 70: 289-296
• 25 Griewank KG, Westekemper H, Murali R. et al Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin Cancer Res 2013; 19: 3143-3152
• 26 Larsen AC. Conjunctival malignant melanoma in Denmark. Epidemiology, treatment and prognosis with special emphasis on tumorigenesis and genetic profile. Acta Ophthalmol 2016; 94: 842
• 27 Damato B, Coupland SE. An audit of conjunctival melanoma treatment in Liverpool. Eye (Lond) 2009; 23 (04) 801-809
• 28 Shields CL. Conjunctival melanoma: risk factors for recurrences, exenteration, metastasis and death in 150 consecutive patients. Trans Am Ophthalmol Soc 2000; 98: 471-492
• 29 Damato B, Coupland S. Management of conjunctival melanoma. Expert Rev Anticancer Ther 2009; 9: 1227-1239
• 30 Finger PT. “Finger-tip” cryotherapy probes: treatment of squamous and melanocytic conjunctival neoplasia. Br J Ophthalmol 2005; 89: 942-945
• 31 Westekemper H, Anastassiou G, Sauerwein W. et al Analysis of ocular surface alterations following proton beam radiation in eyes with conjunctival malignant melanoma. Ophthalmologe 2006; 103: 588-595
• 32 Brouwer NJ, Marinkovic M, Luyten GPM. et al Pigmentation of conjunctival melanoma recurrences and outcome. Graefes Arch Clin Exp Ophthalmol 2019; 257: 1783-1788
• 33 Larsen AC, Dahl C, Dahmcke CM. et al BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions. Acta Ophthalmol 2016; 94: 463-470
• 34 Kenawy N, Kalirai H, Sacco JJ. et al Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome. Pigment Cell Melanoma Res 2019; 32: 564-575
• 35 Wierenga APA, Cao J, Luyten GPM. et al Immune Checkpoint Inhibitors in Uveal and Conjunctival Melanoma. Int Ophthalmol Clin 2019; 59: 53-63
• 36 Glossmann JP, Skoetz N, Starbatty B. et al Konjunktivales Melanom. Standardisiertes Vorgehen in Diagnostik, Therapie und Nachsorge. Ophthalmologe 2018; 115: 489-498
• 37 Shields CL, Demirci H, Karatza E. et al Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors. Ophthalmology 2004; 111: 1747-1754
• 38 Gichuhi S, Sagoo MS, Weiss HA. et al Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health 2013; 18: 1424-1443
• 39 Reynolds JW, Pfeiffer ML, Ozgur O. et al Prevalence and Severity of Ocular Surface Neoplasia in African Nations and Need for Early Interventions. J Ophthalmic Vis Res 2016; 11: 415-421
• 40 Di Girolamo N. Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia. Eye (Lond) 2012; 26: 202-211
• 41 Shields C, Shields JA. Tumors of the conjunctiva and cornea. Indian J Ophthalmol 2019; 67: 1930-1948
• 42 Ogun GO, Ogun OA, Bekibele CO. et al Intraepithelial and invasive squamous neoplasms of the conjunctiva in Ibadan, Nigeria: a clinicopathological study of 46 cases. Int Ophthalmol 2009; 29: 401-409
• 43 Meta M, Fay A. Squamous cell carcinoma of the eyelid and the conjunctiva. Int Ophthalmol Clinics 2009; 49: 111-121
• 44 Coupland SE, Hummel M, Stein H. Ocular adnexal lymphomas: five case presentations and a review of the literature. Survey Ophthalmol 2002; 47: 470-490
• 45 Ferry JA, Fung CY, Zukerberg L. et al Lymphoma of the ocular adnexa: A study of 353 cases. Am J Surg Pathol 2007; 31: 170-184
• 46 Kirkegaard MM, Rasmussen PK, Coupland SE. et al Conjunctival lymphoma – an international multicenter retrospective study. JAMA Ophthalmol 2016; 134: 406-414
• 47 Kirkegaard MM, Coupland SE, Prause JU. et al Malignant lymphoma of the conjunctiva. Surv Ophthalmol 2015; 60: 444-458
• 48 Nückel H, Meller D, Steuhl K-P. et al. Anti-CD20 monoclonal antibody therapy in relapsed MALT lymphoma of the conjunctiva. Eur J Haematol 2004; 73: 258-262
• 49 Brouwer NJ, Marinkovic M, Jochems A. et al Conjunctival metastasis of a cutaneous melanoma. Ocul Oncol Pathol 2018; 4: 107-111
• 50 Yadav R, Battoo AJ, Mir AW. et al Bulbar conjunctival metastasis from mucoepidermoid carcinoma of parotid-a case report and review of literature. World J Surg Oncol 2017; 15: 10
• 51 Sahin A, Yildirim N, Sahin DG. et al Conjunctival metastasis as an initial sign of small cell lung cancer. Case Rep Med 2014; 2014: 614353