Planta Med 2021; 87(06): 489-497
DOI: 10.1055/a-1429-3396
Natural Product Chemistry and Analytical Studies
Original Papers

Rhytidhyesters A – D, 4 New Chlorinated Cyclopentene Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9

Sha Zhang
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Wenxuan Wang
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Jianbin Tan
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Fenghua Kang
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Dekun Chen
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Kangping Xu
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
,
Zhenxing Zou
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
› Author Affiliations
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Abstract

Four new chlorinated cyclopentene derivatives, rhytidhyesters A – D (1 – 4), were isolated from Rhytidhysteron sp. BZM-9, an endophytic fungus from Leptospermum brachyandrum. The planar structures of compounds 1 – 4 were mainly elucidated by 1D, 2D NMR, and HRESIMS data. Their absolute configurations were established by X-ray crystallographic analysis, quantum chemical 13C NMR, and electronic circular dichroism calculations. Compounds 1 and 2 are a pair of epimers. Moreover, all the isolated compounds were evaluated for cytotoxic activities against 3 human colon cancer cell lines (SW620, HT29, SW480) and antimicrobial activity against Staphylococcus aureus. All compounds exhibited weak to moderate antiproliferative activities with IC50 values ranging from 15.4 to 37.7 µM but were inactive against S. aureus.

Supporting Information



Publication History

Received: 22 August 2020

Accepted after revision: 07 March 2021

Article published online:
23 March 2021

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