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Tierarztl Prax Ausg K Kleintiere Heimtiere 2021; 49(03): 212-218
DOI: 10.1055/a-1396-3101
Kasuistik

Granulomatöse Kolitis bei einem Französische-Bulldogge-Welpen

Granulomatous colitis in a French Bulldog puppy
Miriam Keiner
Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen
,
Laura Balzhäuser
,
Arne Güssow
,
Andreas Moritz
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Zusammenfassung

Eine 6 Monate alte Französische Bulldogge wurde aufgrund von chronischem Dickdarmdurchfall über 4 Monate vorgestellt. Die Diagnostik des überweisenden Tierarztes hatte Hinweise auf eine chronisch entzündliche Darmerkrankung ergeben, doch war die Therapie (Futtermittelumstellung, antibakterielle, anthelminthische, antiinflammatorische und immunsuppressive Medikation) erfolglos geblieben. Mittels Endoskopie sowie histologischer Untersuchung entnommener Gewebeproben wurden ausgeprägte Erosionen und Ulzerationen der Kolonschleimhaut detektiert. Durch Fluoreszenz-in-situ-Hybridisierung ließen sich invasive Escherichia coli-Bakterien in der Kolonschleimhaut und in Kolonmakrophagen nachweisen und damit eine granulomatöse Kolitis diagnostizieren. Der Hund zeigte unter 8-wöchiger Therapie mit Enrofloxacin eine vollständige Remission der klinischen Symptomatik. Diese Kasuistik beschreibt die erste erfolgreiche Behandlung einer granulomatösen Kolitis mit Enrofloxacin bei einer vergleichsweise jungen Französischen Bulldogge in Deutschland und soll den Leser für diesen Erkrankungskomplex bei (jungen) Hunden sensibilisieren.

Abstract

A 6-month-old French bulldog was presented due to chronic large intestinal diarrhea of 4 months duration. The diagnostic procedures initiated by the referring veterinarian had resulted in a tentative diagnosis of chronic enteropathy, however treatment consisting of elimination diet as well as antibiotic, anthelmintic, anti-inflammatory and immunosuppressive medication had been unsuccessful. By means of endoscopy and histological examination, pronounced erosions and ulcerations of the colonic mucosa were detected. Fluorescence in situ hybridization enabled the identification of invasive Escherichia coli within the colonic mucosa and colonic macrophages, allowing for the diagnosis of granulomatous colitis. The dog showed complete remission of clinical signs following 8 weeks of treatment with enrofloxacin. This case report describes the first successful treatment of granulomatous colitis with enrofloxacin in a French bulldog puppy in Germany and is intended to sensitize the reader to this disease in (young) dogs.

Schlüsselwörter

Hund - chronischer Dickdarmdurchfall - Escherichia coli - Fluoreszenz-in-situ-Hybridisierung (FISH) - Fluorchinolone - Enrofloxacin

Key words

Dog - chronic large bowel diarrhea - Escherichia coli - fluorescence in situ hybridization (FISH) - fluoroquinolones - enrofloxacin


Publication History

Received: 14 May 2020

Accepted: 06 August 2020

Article published online:
22 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Van Kruiningen HJ, Montali RJ, Strandberg JD. et al. A granulomatous colitis of dogs with histologic resemblance to Whipple’s disease. Pathol Vet 1965; 2 (06) 521-544
    PubMedGoogle Scholar
  • 2 Mansfield CS, James FE, Craven M. et al. Remission of histiocytic ulcerative colitis in Boxer dogs correlates with eradication of invasive intramucosal Escherichia coli. J Vet Intern Med 2009; 23 (05) 964-969
    CrossrefPubMedGoogle Scholar
  • 3 Manchester AC, Hill S, Sabatino B. et al. Association between granulomatous colitis in French Bulldogs and invasive Escherichia coli and response to fluoroquinolone antimicrobials. J Vet Intern Med 2013; 27 (01) 56-61
    CrossrefPubMedGoogle Scholar
  • 4 Tanaka H, Nakayama M, Takase K. Histiocytic ulcerative colitis in a French bulldog. J Vet Med Sci 2003; 65 (03) 431-433
    CrossrefPubMedGoogle Scholar
  • 5 Mueller M, Dahlem DP, Henrich M. et al. Favourable long-term outcome of granulomatous colitis involving two Escherichia coli strains with multiple antimicrobial resistances in a French bulldog in Germany. Vet Rec Case Reports. 2016 4 (1): e000296
    PubMedGoogle Scholar
  • 6 Lucena R, Novales M, Ginel P. Granulomatous colitis in two French bulldogs unresponsive to fluoroquinolone antimicrobials: a case report. Veterinární Medicína 2017; 62 (05) 292-294
    CrossrefPubMedGoogle Scholar
  • 7 Stokes JE, Kruger JM, Mullaney T. et al. Histiocytic ulcerative colitis in three non-boxer dogs. J Am Anim Hosp Assoc 2001; 37 (05) 461-465
    CrossrefPubMedGoogle Scholar
  • 8 Argenta FF, de Souza SO, Meirelles LS. et al. Histiocytic Ulcerative Colitis in an American Staffordshire Terrier. J Comp Pathol 2018; 165: 40-44
    CrossrefPubMedGoogle Scholar
  • 9 Carvallo FR, Kerlin R, Fredette C. et al. Histiocytic typhlocolitis in two colony Beagle dogs. Exp Toxicol Pathol 2015; 67 (02) 219-221
    CrossrefPubMedGoogle Scholar
  • 10 Leal RO, Simpson K, Fine M. et al. Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat. JFMS Open Rep. 2017 3 (2): 20551169177311682017
    PubMedGoogle Scholar
  • 11 Matsumoto I, Nakashima K, Morita H. et al. Escherichia coli-induced granulomatous colitis in a cat. JFMS Open Rep. 2019 5 (1): 2055116919836537
    PubMedGoogle Scholar
  • 12 Van Kruiningen HJ, Dobbins WO. Feline histiocytic colitis. A case report with electron microscopy. Vet Pathol 1979; 16 (02) 215-222
    CrossrefPubMedGoogle Scholar
  • 13 Simpson KW, Dogan B, Rishniw M. et al. Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs. Infect Immun 2006; 74 (08) 4778-4792
    CrossrefPubMedGoogle Scholar
  • 14 Hostutler RA, Luria BJ, Johnson SE. et al. Antibiotic-responsive histiocytic ulcerative colitis in 9 dogs. J Vet Intern Med 2004; 18 (04) 499-504
    CrossrefPubMedGoogle Scholar
  • 15 Davies DR, O’Hara AJ, Irwin PJ. et al. Successful management of histiocytic ulcerative colitis with enrofloxacin in two Boxer dogs. Aust Vet J 2004; 82 (01/02) 58-61
    CrossrefPubMedGoogle Scholar
  • 16 Churcher R, Watson A. Canine histiocytic ulcerative colitis. Australian Vet J 1997; 75 (10) 710-713
    CrossrefPubMedGoogle Scholar
  • 17 Gladwin NE, Penninck DG, Webster CRL. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs. Am J Vet Res 2014; 75 (04) 349-353
    CrossrefPubMedGoogle Scholar
  • 18 Lechowski R, Cotard JP, Boulouis HJ. et al. Proper use of Quinolones for canine colitis ambulatory treatment: literature review and REQUEST guidelines. Pol J Vet Sci 2013; 16 (01) 193-197
    CrossrefPubMedGoogle Scholar
  • 19 Suchodolski JS. Diagnosis and interpretation of intestinal dysbiosis in dogs and cats. Vet J 2016; 215: 30-37
    CrossrefPubMedGoogle Scholar
  • 20 Heilmann RM, Steiner JM. Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs. J Vet Intern Med 2018; 32 (05) 1495-1508
    CrossrefPubMedGoogle Scholar
  • 21 Kather S, Grützner N, Kook PH. et al. Review of cobalamin status and disorders of cobalamin metabolism in dogs. J Vet Intern Med 2020; 34 (01) 13-28
    CrossrefPubMedGoogle Scholar
  • 22 Dandrieux JRS. Inflammatory bowel disease versus chronic enteropathy in dogs: are they one and the same? IBD versus CE. J Small Anim Pract 2016; 57 (11) 589-599
    CrossrefPubMedGoogle Scholar
  • 23 Craven M, Mansfield CS, Simpson KW. Granulomatous colitis of boxer dogs. Vet Clin North Am Small Anim Pract 2011; 41 (02) 433-445
    CrossrefPubMedGoogle Scholar
  • 24 Parker HG, Kim LV, Sutter NB. et al. Genetic structure of the purebred domestic dog. Science 2004; 304 (5674) 1160-1164
    CrossrefPubMedGoogle Scholar
  • 25 Van Kruiningen HJ, Civco IC, Cartun RW. The comparative importance of E. coli antigen in granulomatous colitis of Boxer dogs. APMIS 2005; 113 (06) 420-425
    CrossrefPubMedGoogle Scholar
  • 26 Hugot JP, Chamaillard M, Zouali H. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 411 (6837) 599-603
    CrossrefPubMedGoogle Scholar
  • 27 Washabu RJ. Section VI: Diseases of the Gastrointestinal Tract: Chapter 58: Large Intestine. In: Washabu RJ, Day MJ. eds. Canine and Feline Gastroenterology. 1st ed.. St. Louis: Elsevier Saunders; 2012: 742-744
    Google Scholar
  • 28 Craven M, Dogan B, Schukken A. et al. Antimicrobial resistance impacts clinical outcome of granulomatous colitis in boxer dogs. J Vet Intern Med 2010; 24 (04) 819-824
    CrossrefPubMedGoogle Scholar
  • 29 Burkhardt JE, Walterspiel JN, Schaad UB. Quinolone arthropathy in animals versus children. Clin Infect Dis 1997; 25 (05) 1196-1204
    CrossrefPubMedGoogle Scholar
  • 30 Takizawa T, Hashimoto K, Minami T. et al. The comparative arthropathy of fluoroquinolones in dogs. Hum Exp Toxicol 1999; 18 (06) 392-399
    CrossrefPubMedGoogle Scholar
  • 31 Patel K, Goldman JL. Safety Concerns Surrounding Quinolone Use in Children. J Clin Pharmacol 2016; 56 (09) 1060-1075
    CrossrefPubMedGoogle Scholar
  • 32 Plumb DC. Enrofloxacin. In: Plumb DC. ed. Plumb’s Veterinary Drug Handbook. 9th ed.. Hoboken: Wiley-Blackwell; 2018: 425-429
    Google Scholar
  • 33 Löscher W, Ungemach FR, Kroker R. Hrsg. Pharmaka zur Behandlung und Verhütung bakterieller Infektionen: Enrofloxacin. In: Pharmakotherapie bei Haus- und Nutztieren. 7. Aufl.. Berlin: Parey; 2006: 276
    Google Scholar
  • 34 Scott DW, Peters J, Miller WH. Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs. Can Vet J 2006; 47 (10) 999-1002
    PubMedGoogle Scholar
  • 35 Bayley A. Enrofloxacin. In: Compendium of Veterinary Products VII. Port Huron: North American Compendiums; 2003: 1148-1150
    Google Scholar
  • 36 Dandrieux JRS, Mansfield CS. Chronic Enteropathy In Canines: Prevalence, Impact And Management Strategies. Vet Med (Auckl) 2019; 10: 203-214
    PubMedGoogle Scholar
  • 37 Allenspach K, Culverwell C, Chan D. Long-term outcome in dogs with chronic enteropathies: 203 cases. Vet Rec 2016; 178 (15) 368
    CrossrefPubMedGoogle Scholar
  • 38 Rutgers HC, Batt RM, Elwood CM. et al. Small intestinal bacterial overgrowth in dogs with chronic intestinal disease. J Am Vet Med Assoc 1995; 206 (02) 187-193
    PubMedGoogle Scholar
  • 39 Trehy MR, German AJ, Silvestrini P. et al. Hypercobalaminaemia is associated with hepatic and neoplastic disease in cats: a cross sectional study. BMC Vet Res 2014; 10 (01) 175
    CrossrefPubMedGoogle Scholar