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Der Nuklearmediziner 2021; 44(02): 152-159
DOI: 10.1055/a-1395-0735
Aktuelle Trends aus den Radiopharmazeutischen Wissenschaften

Frischer Wind für Integrine

A New Paradigm for Integrins
Susanne Kossatz
1   Klinik und Poliklinik für Nuklearmedizin, Klinikum Rechts der Isar; Zentralinstitut für Translationale Krebsforschung (TranslaTUM); Fakultät für Chemie; Technische Universität München, Deutschland
,
Johannes Notni
2   Institut für Pathologie und Pathologische Anatomie, Technische Universität München, Deutschland
3   Experimentelle Radiopharmazie, Klinik für Nuklearmedizin, Universitätsklinikum Essen, Deutschland
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Zusammenfassung

Selektive PET- oder SPECT- Radiopharmaka sind inzwischen nicht nur für αvβ3, sondern auch weitere der 24 verschiedenen Integrine verfügbar, zum Beispiel α5β1, αvβ6, αvβ8 und α6. Da diese unter anderem auch von verschiedenen Karzinomen und im Zuge von Fibrose exprimiert werden, ist die Vorstellung, dass Integrine nur als Zielstrukturen für die Bildgebung von Angiogenese in Betracht kommen, endgültig überholt. Die derzeit besten Aussichten auf eine breite klinische Anwendung, sowohl diagnostisch als auch therapeutisch, haben derzeit αvβ6-Integrin-Radiopharmaka, da αvβ6 von vielen malignen Krebsarten (v. a. Pankreas-, Plattenepithel-, Basalzell-, Lungen- und Colonkarzinom) überexprimiert wird.

Abstract

Today, selective PET- and SPECT radiopharmaceuticals are not only available for αvβ3, but also for others of the 24 known integrin subtypes, including α5β1, αvβ6, αvβ8 und α6. These integrins are widely expressed by different carcinomas and in the course of fibrosis. Hence, integrin imaging offers a range of clinically relevant applications beyond imaging of angiogenesis. αvβ6 integrin radiopharmaceuticals, both diagnostic and therapeutic, have emerged as highly promising candidates for a clinical career, since αvβ6 is expressed by many malignant cancers, such as pancreatic, basal cell, squamous cell, lung, and colon carcinoma.

Schlüsselwörter

Integrine - Radiopharmaka - Molekulare Bildgebung - Pankreaskarzinom - Fibrose

Keywords

Integrins - Radipharmaceuticals - Molecular imaging - Pancreatic carcinoma - Fibrosis


Publication History

Article published online:
10 June 2021

© 2021. Thieme. All rights reserved.

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