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Planta Med 2022; 88(05): 356-366
DOI: 10.1055/a-1385-8863
Biological and Pharmacological Activity
Original Papers

Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry

Bárbara Cabral
1   Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
,
Tays Amanda Felisberto Gonçalves
3   Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
,
Lucas Silva Abreu
3   Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
,
Anderson Wilbur Lopes Andrade 
4   Department of Biophysics and Pharmacology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil
,
Fátima de Lourdes Assunção Araújo de Azevedo
3   Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
,
Francker Duarte de Castro
1   Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
,
Josean Fechine Tavares
3   Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
,
Gerlane Coelho Bernardo Guerra
4   Department of Biophysics and Pharmacology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Brazil
,
Adriana Augusto de Rezende
2   Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil
,
Isac Almeida de Medeiros
3   Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
,
Silvana Maria Zucolotto 
1   Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
› InstitutsangabenGefördert durch: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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Abstract

Hypertension is a chronic disease and a global health problem. Due to its high prevalence, it constitutes the most important risk factor for cardiovascular disease. Fruit peels from Passiflora edulis fo. flavicarpa are rich in bioactive natural compounds that may have action in hypertension. This study aimed to perform a fingerprinting analysis of Passiflora edulis fruit peel extract and evaluate its actions on the cardiovascular system in an in vivo model. The extract was obtained from the dried and powdered fruit peels of Passiflora edulis. Glycoside flavonoids were identified in the extract by HPLC-ESI-MSn. The extract showed a significant hypotensive effect after 28 days of treatment and improved vascular function in the mesenteric artery. This effect was verified by decreased vascular hypercontractility and increased vasorelaxant in response to sodium nitroprusside and acetylcholine. There was also a decrease in endothelial dysfunction, which can be attributed to nitric oxideʼs increased bioavailability. Thus, we hypothesize that all these effects contributed to a reduction in peripheral vascular resistance, leading to a significant hypotensive effect. These results are novel for fruit peels from P. edulis. Also, there was a decrease in plasma and cardiac malondialdehyde levels and an increase in glutathione, suggesting a reduction in oxidative stress, as well as an increase of anti-inflammatory cytokines such as IL-10 in the plasma. This study demonstrated that the extract can be a new source of raw material to be applied as food or medicine adjuvant for treating hypertension.

Key words

Passifloraceae - Passiflora edulis fo. flavicarpa - oxidative stress - glycoside flavonoids - antihypertensive - vascular function


Publikationsverlauf

Eingereicht: 08. Dezember 2019

Angenommen nach Revision: 06. Februar 2021

Artikel online veröffentlicht:
03. August 2021

© 2021. Thieme. All rights reserved.

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