Medical Therapy of Aggressive Pituitary Tumors

Abstract

The rare aggressive pituitary adenoma presents a special challenge, due to the heterogenous presentation of the disease. The prognosis of aggressive pituitary adenomas has been improved due to recent studies demonstrating clinically-relevant efficacy of temozolomide, which is now considered first-line chemotherapy. However, there is limited data on second-line therapies in patients with treatment failure. This review presents a summary on the potential of medical therapies in aggressive pituitary tumors.

Key words

carcinoma - chemotherapy - temozolomide - bevacizumab - tyrosine kinase inhibitor - everolimus - cyclin-dependent kinase inhibitor - checkpoint inhibitor

Publication History

Received: 09 October 2020
Received: 01 December 2020

Accepted: 07 December 2020

Article published online:
09 March 2021

• References

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