Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00040811.xml
Neurologie up2date 2022; 05(01): 21-36
DOI: 10.1055/a-1176-7436
DOI: 10.1055/a-1176-7436
Immunvermittelte und erregerbedingte Erkrankungen des ZNS
Autoimmun vermittelte Enzephalitis
Autoimmunenzephalitiden bilden eine heterogene Gruppe neurologischer und psychiatrischer Erkrankungen. Es werden Antikörper-vermittelte Enzephalitiden von den häufig paraneoplastisch auftretenden Antikörper-assoziierten Enzephalitiden unterschieden. Während die Antikörper im ersten Fall direkt krankheitsverursachend sind, dienen sie im zweiten Fall als diagnostischer Biomarker mit hoher Aussagekraft für einen zugrunde liegenden Tumor.
Publication History
Article published online:
09 March 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Prüss H. Autoantibodies in neurological disease. Nat Rev Immunol 2021; 21: 798-813 DOI: 10.1038/s41577-021-00543-w. (PMID: 33976421)
- 2 Graus F, Titulaer MJ, Balu R. et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 2016; 15: 391-404 DOI: 10.1016/S1474-4422(15)00401-9. (PMID: 26906964)
- 3 Dalmau J, Armangué T, Planaguma J. et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol 2019; 18: 1045-1057 DOI: 10.1016/S1474-4422(19)30244-3. (PMID: 31326280)
- 4 Dalmau J, Graus F. Antibody-Mediated Encephalitis. N Engl J Med 2018; 378: 840-851 DOI: 10.1056/NEJMra1708712. (PMID: 29490181)
- 5 Prüss H, Finke C, Holtje M. et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol 2012; 72: 902-911 DOI: 10.1002/ana.23689. (PMID: 23280840)
- 6 Armangué T, Spatola M, Vlagea A. et al. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis. Lancet Neurol 2018; 17: 760-772 DOI: 10.1016/s1474-4422(18)30244-8. (PMID: 30049614)
- 7 Graus F, Vogrig A, Muniz-Castrillo S. et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm 2021; 8: e1014 DOI: 10.1212/nxi.0000000000001014. (PMID: 34006622)
- 8 Graus F, Delattre JY, Antoine JC. et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004; 75: 1135-1140 DOI: 10.1136/jnnp.2003.034447.. (PMID: 15258215)
- 9 Saiz A, Blanco Y, Sabater L. et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 2008; 131: 2553-2563 DOI: 10.1093/brain/awn183. (PMID: 18687732)
- 10 Graus F, Dalmau J. Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors. Nat Reviews Clin Oncol 2019; 16: 535-548 DOI: 10.1038/s41571-019-0194-4. (PMID: 30867573)
- 11 Herken J, Prüss H. Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients. Front Psychiatry 2017; 8: 25 DOI: 10.3389/fpsyt.2017.00025. (PMID: 28261116)
- 12 Rößling R, Prüss H. Apheresis in Autoimmune Encephalitis and Autoimmune Dementia. J Clin Med 2020; 9: 2683 DOI: 10.3390/jcm9092683. (PMID: 32824982)
- 13 Gelpi E, Hoftberger R, Graus F. et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol 2016; 132: 531-543 DOI: 10.1007/s00401-016-1591-8. (PMID: 27358064)
- 14 Werner J, Jelcic I, Schwarz EI. et al. Anti-IgLON5 Disease: A New Bulbar-Onset Motor Neuron Mimic Syndrome. Neurol Neuroimmunol Neuroinflamm 2021; 8: e962 DOI: 10.1212/nxi.0000000000000962.. (PMID: 33531378)
- 15 Blinder T, Lewerenz J. Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis. Front Neurol 2019; 10: 804 DOI: 10.3389/fneur.2019.00804.. (PMID: 31404257)
- 16 Schmitt SE, Pargeon K, Frechette ES. et al. Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology 2012; 79: 1094-1100 DOI: 10.1212/WNL.0b013e3182698cd8.
- 17 Gultekin SH, Rosenfeld MR, Voltz R. et al. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 2000; 123: 1481-1494 DOI: 10.1093/brain/123.7.1481. (PMID: 10869059)
- 18 Scheibe F, Prüss H, Mengel AM. et al. Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology 2017; 88: 366-370 DOI: 10.1212/WNL.0000000000003536. (PMID: 28003505)
- 19 Wickel J, Chung HY, Platzer S. et al. Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of bortezomib in patients with severe autoimmune encephalitis. Trials 2020; 21: 625 DOI: 10.1186/s13063-020-04516-7. (PMID: 32641101)
- 20 van Sonderen A, Thijs RD, Coenders EC. et al. Anti-LGI1 encephalitis: Clinical syndrome and long-term follow-up. Neurology 2016; 87: 1449-1456 DOI: 10.1212/wnl.0000000000003173. (PMID: 27590293)
- 21 Finke C, Prüss H, Heine J. et al. Evaluation of Cognitive Deficits and Structural Hippocampal Damage in Encephalitis With Leucine-Rich, Glioma-Inactivated 1 Antibodies. JAMA Neurol 2017; 74: 50-59 DOI: 10.1001/jamaneurol.2016.4226. (PMID: 27893017)