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Horm Metab Res 2020; 52(10): 724-731
DOI: 10.1055/a-1161-0088
Endocrine Care

Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis

Mengwei Liu
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Mengke Shang
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Yue Wang
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Qian Li
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Xiuping Liu
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Luping Yang
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Qian Zhang
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Kaili Zhang
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Shan Liu
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Fangfang Nie
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Fanxin Zeng
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Youhan Wen
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
,
Wanyang Liu
1   Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China
› Author Affiliations Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 81573240).
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Abstract

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the major factors of morbidity and mortality in the patients with diabetes mellitus (DM). Growing studies have investigated the relationship between the TNF-α-308G/A polymorphism and the susceptibility to DN and DR, without achieving consensus. Thus, we conducted this meta-analysis to reach more comprehensive conclusions for these issues. Eligible studies were retrieved through electronic databases such as PubMed, Embase, Web of Science and China National Knowledge Infrastructure. Summary of odds ratios (OR) and 95% confidence intervals (CIs) were generated to evaluate the intensity of the associations. Statistical analyses were performed by STATA 11.0 and RevMan 5.2. There are fourteen eligible publications involving nineteen studies in this meta-analysis. TNF-α-308G/A polymorphism was significantly related to increasing risk of DN under recessive model (OR=1.37, 95% CI=1.03–1.83) and homozygous model (OR=1.54, 95% CI=1.15–2.06). Moreover, the similar results were also obtained in Asian groups for DN (recessive: OR=1.69, 95% CI=1.18–2.42; homozygous: OR=1.99, 95% CI=1.38–2.86; respectively), and significant association was also detected between TNF-α-308G/A and DN susceptibility in type 2 DM in recessive model (OR=1.39, 95% CI=1.02–1.89). No significant association was observed between TNF-α-308G/A and DR susceptibility in total analyses and subgroup analyses by ethnicity and type of DM. TNF-α-308G/A polymorphism may enhance the susceptibility to diabetic nephropathy, especially in Asian population and in T2DM patients, but not diabetic retinopathy.

Key words

TNF-a-308G/A - polymorphism - meta-analysis - diabetic nephropathy - diabetic retinopathy - genetic models

Supplementary Material



Publication History

Received: 28 November 2019

Accepted after revision: 09 April 2020

Article published online:
05 May 2020

© 2020. Thieme. All rights reserved.

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