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Exp Clin Endocrinol Diabetes 2021; 129(10): 699-704
DOI: 10.1055/a-1038-3883
Review

Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview

Niki Katsiki
1   First Department of Internal Medicine, Diabetes Centre, Division of Endocrinology and Metabolism, AHEPA University Hospital, Thessaloniki, Greece
,
Paschalis Steiropoulos
2   Department of Pneumonology, Democritus University of Thrace School of Health Sciences, Alexandroupolis, Greece
,
Nikolaos Papanas
3   Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
,
Dimitri P. Mikhailidis
4   Department of Clinical Biochemistry, University College London, Royal Free Hospital Campus, London, United Kingdom of Great Britain and Northern Ireland
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Abstract

Chronic obstructive pulmonary disease (COPD) is a common disease with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Apart from cigarette smoking, certain occupational and environmental exposures, low socioeconomic status and genetic factors may contribute to the pathogenesis of COPD. Comorbidities, e. g. diabetes mellitus (DM), can negatively affect quality of life, COPD outcomes and cardiovascular risk. The present narrative review considers the potential links between COPD and DM, such as systemic inflammation, oxidative stress, hypoxaemia and hyperglycaemia. The effects of antidiabetic drugs on lung function and COPD outcomes, as well as the possibility of common therapeutic modalities are also briefly considered. Further research is needed in this field to elucidate these relationships as well as their potential clinical implications in daily practice.

Key words

chronic obstructive pulmonary disease - obesity - type 2 diabetes mellitus


Publication History

Received: 21 May 2019
Received: 03 October 2019

Accepted: 30 October 2019

Article published online:
18 November 2019

© 2019. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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