Postnatale Ernährung bei sehr kleinen Frühgeborenen

Eine bedarfsgerechte individuelle klinische Ernährung in der Frühgeborenenmedizin wirkt sich positiv auf Morbidität und Mortalität, aber auch auf langfristige Programmierungseffekte aus. Leitlinienbasierte und standardisierte Ernährungsprotokolle sind darum ein Investment in die Gesundheit von Neugeborenen und unsere Gesellschaft. Der Beitrag liefert hierzu einen Überblick.

Schlüsselwörter

parenteral - enteral - Nährstoffbedarf - Stillen - Programmierungseffekte

• Literatur

• 1 Stensvold HJ, Strommen K, Lang AM. et al. Early enhanced parenteral nutrition, hyperglycemia, and death among extremely low-birth-weight infants. JAMA Pediatr 2015; 169: 1003-1010
• 2 Hulst J, Joosten K, Zimmermann L. et al. Malnutrition in critically ill children: from admission to 6 months after discharge. Clin Nutr 2004; 23: 223-232
• 3 Mameli C, Mazzantini S, Zuccotti GV. Nutrition in the first 1000 days: The origin of childhood obesity. Int J Environ Res Public Health 2016; 13: 838
• 4 Edmonds CJ, Isaacs EB, Cole TJ. et al. The effect of intrauterine growth on verbal IQ scores in childhood: A study of monozygotic twins. Pediatrics 2010; 126: e1095-e1101
• 5 Hayakawa M, Okumura A, Hayakawa F. et al. Nutritional state and growth and functional maturation of the brain in extremely low birth weight infants. Pediatrics 2003; 111: 991-995
• 6 Friis-Hansen B. Body water compartments in children: changes during growth and related changes in body composition. Pediatrics 1961; 28: 169-181
• 7 Fomon SJ, Haschke F, Ziegler EE. et al. Body composition of reference children from birth to age 10 years. Am J Clin Nutr 1982; 35: 1169-1175
• 8 Fawer C-L, Torrado A, Guignard JP. Maturation of renal function in full-term and premature neonates. Helv Paediatr Acta 1979; 34: 11-21
• 9 Lucas A. Programming by early nutrition in man. Ciba Found Symp 1991; 156: 38-50 , discussion 50–55
• 10 Okumura A, Hayakawa M, Oshiro M. et al. Nutritional state, maturational delay on electroencephalogram, and developmental outcome in extremely low birth weight infants. Brain Developm 2010; 32: 613-618
• 11 Jasani B, Patole S. Standardized feeding regimen for reducing necrotizing enterocolitis in preterm infants: an updated systematic review. J Perinatol 2017; 37: 827-833
• 12 Franco KA, O’Mara K. Impact of computerized provider order entry on total parenteral nutrition in the neonatal intensive care unit. J Pediatr Pharmacol Ther 2016; 21: 339-345
• 13 Morgan J, Young L, McGuire W. Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants. Coch Data Syst Rev 2014; 12: CD001970
• 14 Morgan J, Bombell S, McGuire W. Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants. Coch Data Syst Rev 2013; 3: CD000504
• 15 Oddie SJ, Young L, McGuire W. Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants. Coch Data Syst Rev 2021; 8: CD001241
• 16 Parker LA, Weaver M, Murgas Torrazza RJ. et al. Effect of gastric residual evaluation on enteral intake in extremely preterm infants: A randomized clinical trial. JAMA Pediatr 2019; 173: 534-543
• 17 Aynsley-Green A, Adrian TE, Bloom SR. Feeding and the development of enteroinsular hormone secretion in the preterm infant: effects of continuous gastric infusions of human milk compared with intermittent boluses. Acta Paediatr Scand 1982; 71: 379-383
• 18 de Ville K, Knapp E, Al-Tawil Y. et al. Slow infusion feedings enhance duodenal motor responses and gastric emptying in preterm infants. Am J Clin Nutr 1998; 68: 103-108
• 19 DeMauro SB, Abbasi S, Lorch S. The impact of feeding interval on feeding outcomes in very low birth-weight infants. J Perinatol 2011; 31: 481-486
• 20 Mathur NB, Dwarkadas AM, Sharma VK. et al. Anti-infective factors in preterm human colostrum. Acta Paediatr Scand 1990; 79: 1039-1044
• 21 Chetta KE, Schulz EV, Wagner CL. Outcomes improved with human milk intake in preterm and full-term infants. Semin Perinatol 2021; 45: 151384
• 22 Nasuf AWA, Ojha S, Dorling J. Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. Coch Data Syst Rev 2018; 9: CD011921
• 23 Sharif S, Meader N, Oddie SJ. et al. Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants. Coch Data Syst Rev 2020; 10: CD005496
• 24 Genzel-Boroviczény O, Jenke A, Mihatsch W. et al. AWMF-Leitlinie 024-009 Nekrotisierende Enterokolitis. 2017: 1-24
• 25 Agostoni C, Buonocore G, Carnielli VP. et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50: 85-91
• 26 Domellöf M, Braegger C, Campoy C. et al. Iron requirements of infants and toddlers. J Pediatr Gastroenterol Nutr 2014; 58: 119-129
• 27 Jochum F, Moltu SJ, Senterre T. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Fluid and electrolytes. Clin Nutr 2018; 37: 2344-2353
• 28 Greber-Platzer S, Haiden N, Hauer AC. et al. Parenterale Ernährung von Früh-, Neugeborenen, Kindern und Jugendlichen. Monatsschr Kinderheilkd 2021; 168: 634-643
• 29 Hartnoll G, Bétrémieux P, Modi N. Randomised controlled trial of postnatal sodium supplementation on oxygen dependency and body weight in 25–30 week gestational age infants. Arch Dis Child Fetal Neonatal Ed 2000; 82: F19-F23
• 30 Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Coch Data Syst Rev 2014; 12: CD005496
• 31 Mihatsch W, Fewtrell M, Goulet O. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium. Clin Nutr 2018; 37: 2360-2365
• 32 Joosten K, Embleton N, Yan W. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy. Clin Nutr 2018; 37: 2309-2314
• 33 Mesotten D, Joosten K, van Kempen A. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Carbohydrates. Clin Nutr 2018; 37: 2337-2343
• 34 van Goudoever JB, Carnielli V, Darmaun D. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids. Clin Nutr 2018; 37: 2315-2323
• 35 Lapillonne A, Fidler Mis N, Goulet O. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids. Clin Nutr 2018; 37: 2324-2336
• 36 Vlaardingerbroek H, van Goudoever JB. Intravenous lipids in preterm infants: impact on laboratory and clinical outcomes and long-term consequences. World Rev Nutr Diet 2015; 112: 71-80
• 37 Lapillonne A, Moltu SJ. Long-chain polyunsaturated fatty acids and clinical outcomes of preterm infants. ANM 2016; 69: 35-44
• 38 Chessex P, Laborie S, Nasef N. et al. Shielding parenteral nutrition from light improves survival rate in premature infants. J Parent Ent Nutr 2017; 41: 378-383
• 39 Colantonio DA, Kyriakopoulou L, Chan MK. et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem 2012; 58: 854-868
• 40 Bronsky J, Campoy C, Braegger C. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Vitamins. Clin Nutr 2018; 37: 2366-2378
• 41 Domellöf M, Szitanyi P, Simchowitz V. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Iron and trace minerals. Clin Nutr 2018; 37: 2354-2359