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Planta Med 2019; 85(07): 583-590
DOI: 10.1055/a-0746-8698
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis

Beom-Geun Jo   *
1   College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
No-June Park   *
2   Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Republic of Korea
,
Jonghwan Jegal
1   College of Pharmacy, Pusan National University, Busan, Republic of Korea
,
Sangho Choi
3   International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea
,
Sang Woo Lee
3   International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea
,
Li Wan Yi
4   Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Yunnan, China
,
Su-Nam Kim
2   Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Republic of Korea
,
Min Hye Yang
1   College of Pharmacy, Pusan National University, Busan, Republic of Korea
› Author Affiliations
Further Information

Publication History

received 31 July 2018
revised 05 September 2018

accepted 12 September 2018

Publication Date:
01 October 2018 (online)

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Abstract

Stellera chamaejasme, also known as “Langdu”, has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murine models. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment.

Key words

Stellera chamaejasme - Thymelaeaceae - luteolin 7-O-glucoside - atopic dermatitis - skin barrier function - interleukin 4 - immunoglobulin E

* These authors contributed equally to this work.


 

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