Planta Med 2018; 84(18): 1355-1362
DOI: 10.1055/a-0647-7048
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Fusarihexins A and B: Novel Cyclic Hexadepsipeptides from the Mangrove Endophytic Fungus Fusarium sp. R5 with Antifungal Activities

Xinwei Zhu
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Yu Zhong
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Zihui Xie
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Manlin Wu
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Zhibo Hu
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Weijia Ding
College of Materials and Energy, South China Agricultural University, Guangzhou, China
,
Chunyuan Li
College of Materials and Energy, South China Agricultural University, Guangzhou, China
› Author Affiliations
Further Information

Publication History

received 19 February 2018
revised 14 June 2018

accepted 20 June 2018

Publication Date:
28 June 2018 (online)

Abstract

Two novel cyclic hexadepsipeptides, fusarihexin A (1) and fusarihexin B (2), and two known compounds, cyclo-(L-Leu–L-Leu–D-Leu–L-Leu–L-Val) (3) and cyclo-(L-Leu–L-Leu–D-Leu–L-Leu–L-Ile) (4), were isolated from the marine mangrove endophytic fungus Fusarium sp. R5. Their chemical structures were elucidated on the basis of spectroscopic data and Marfeyʼs analysis. In an in vitro bioassay, fusarihexin A (1) remarkably inhibited three plant pathogenic fungi: Colletotrichum gloeosporioides (Penz.) Sacc., which causes anthracnose in many fruits and vegetables, Colletotrichum musae (Berk. and M. A. Curtis) Arx, which causes crown rot and anthracnose in bananas, and Fusarium oxysporum Schlecht. f. sp. lycopersici (Sacc.) W. C. Snyder et H. N. Hansen, which causes Fusarium wilt and fruit rot in tomatoes. Fusarihexin B (2) strongly inhibited C. gloeosporioides and C. musae. The compounds were more potent than carbendazim, which is widely used as an agricultural and horticultural fungicide worldwide.

Supporting Information

 
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