Abstract
Background The importance of high quality preprocedural bowel preparation is widely acknowledged,
but suboptimal bowel cleansing still occurs in up to 20 % of all colonoscopy patients.
The aim of this study was to evaluate the performance of a novel intraprocedural cleaning
device for cleaning poorly prepared colons.
Methods This multicenter feasibility study included patients aged 18 – 75 years who were
referred for colonoscopy. Intraprocedural cleaning was performed in patients after
a limited preprocedural bowel preparation regimen (2 days of dietary restrictions
and 2 × 10 mg bisacodyl). The primary outcome was the proportion of adequately prepared
patients (Boston Bowel Preparation scale [BBPS] ≥ 2 in each segment) before and after
segmental washing with the new device. Secondary outcomes included: cecal intubation
rate, procedure time, system usability, patient satisfaction, and safety.
Results 47 patients (42.6 % male), with a median age of 61 years (interquartile range [IQR]
46 – 67 years), were included at three clinical sites. Cecal intubation was achieved
in 46/47 patients (97.9 %). The cleaning device significantly improved the proportion
of patients with adequate bowel cleansing (from 19.1 % to 97.9 %; P < 0.001) and median BBPS score (from 3.0 [IQR 0.0 – 5.0] to 9.0 [IQR 8.0 – 9.0]).
Median cecal intubation time and total procedure time were 16.5 minutes (IQR 9.0−28.3)
and 34.0 minutes (IQR 25.0 – 42.8), respectively. Physicians were satisfied with the
ease of use of the device and it was well tolerated by patients. No severe adverse
events occurred during the study period.
Conclusions This feasibility study suggests that the intraprocedural cleaning device appears
to be safe and effective in cleaning poorly prepared colons to an adequate level,
allowing a thorough colorectal examination.
