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Exp Clin Endocrinol Diabetes 2019; 127(05): 276-280
DOI: 10.1055/a-0630-0232
Article
© Georg Thieme Verlag KG Stuttgart · New York

Pleiotropic Effect of Lipoprotein-Apheresis on the Soluble Form of Activated Leukocyte Cell Adhesion Molecule (sALCAM) in Familial Hypercholesterolaemia

Rüdiger von Bauer
1   SRH Kliniken GmbH, Karlsbad, Germany
,
Dimitrios Oikonomou
2   Internal Medicine 1 and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
,
Alba Sulaj
3   Internal Medicine I, Universitatsklinikum Heidelberg, Heidelberg, Germany
,
Stefan Kopf
4   Department of Medicine 1, University of Heidelberg, Heidelberg, Germany
,
Thomas Fleming
5   University of Heidelberg, Heidelberg, Germany
,
Gottfried Rudofsky
6   Kantonsspital Olten, Olten, Switzerland
,
Peter Nawroth
7   Internal Medicine 1 and Clinical Chemistry, UniversitätsKlinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany
› Author Affiliations
Further Information

Publication History

received 31 August 2017
revised 06 April 2018

accepted 27 April 2018

Publication Date:
11 June 2018 (online)

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Abstract

Introduction/Background Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.

Key words

Atherosclerosis - inflammation - pattern recognition receptor - lipoproteins
 

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