An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Nasim Babaknejad; Hashem Nayeri; Roohullah Hemmati; Somaye Bahrami; Ahmad Esmaillzadeh

doi:10.1055/a-0623-2909

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2018; 50(06): 441-452
DOI: 10.1055/a-0623-2909

Review

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Nasim Babaknejad

¹Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

²Department of Biology, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran

³Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

,

Hashem Nayeri

³Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

,

Roohullah Hemmati

²Department of Biology, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran

,

Somaye Bahrami

³Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

,

Ahmad Esmaillzadeh

⁴Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

⁵Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

⁶Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

› Author Affiliations

Abstract

Fibroblast growth factors (FGFs) are responsible for the regulation of a wide range of biological functions, among which cellular proliferation, survival, migration, and differentiation could be pointed out. FGF19 controls the enterohepatic bile acid/cholesterol system, and FGF21 modulates fatty acid/glucose metabolism. Obesity, type 2 diabetes, coronary artery disease, and cancer, all can alter FGF21 circulating concentrations. In contrast to FGF21, metabolic diseases exhibit reduced serum FGF19 levels. Accordingly, FGF19 and FGF21 play important roles in regulating glucose and lipid metabolism. Hence, we present here a timely review on the relationship between FGF19/21 and metabolic diseases, especially obesity, and their probable role in development and treatment of obesity seems necessary.

Key words

FGF21 - FGF19 - metabolic disorders - obesity

Full Text

References

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