Laryngorhinootologie 2018; 97(04): 276-286
DOI: 10.1055/a-0575-3564
Facharztwissen HNO
© Georg Thieme Verlag KG Stuttgart · New York

Endoskopische Frühdiagnostik von Karzinomen im oberen Aerodigestivtrakt

Endoscopic early diagnosis of carcinomas in upper respiratory and digestive tract
Nikolaos Davaris
,
Susanne Voigt-Zimmermann
,
Anna-Maria Cyran
,
Christoph Arens
Further Information

Publication History

Publication Date:
10 April 2018 (online)

Zusammenfassung

Der obere Aerodigestivtrakt ist mit endoskopischen Methoden gut zugänglich. Die Entwicklung moderner endoskopisch bildgebender Verfahren (EBV) hat dazu beigetragen, Tumorerkrankungen im oberen Aerodigestivtrakt frühzeitig zu entdecken und minimalinvasiv, onkologisch wirksam sowie funktionserhaltend zu behandeln. Damit wird ein gutes onkologisches Ergebnis bei Erhalt der Lebensqualität und Reduzierung der Mortalität und Komplikationsrate erreicht.

Abstract

Modern endoscopic imaging techniques make it possible to detect tumor diseases of the upper respiratory and digestive tract and treat them minimally invasive – with a good oncologic outcome and maintaining the functionality of the tissue.

Horizontal techniques permit the inspection of big mucous membrane surfaces, searching vor areas suspicious of dysplasia or tumor. They can be used as screening techniques. Vertical techniques serve for precise examination of in-depth expansion, infiltration chraracteristics and dignity of known lesions. Cellular techniques deal with the detection of cellular changes in vivo. As the techniques have different advantages and disandvantages, it is recommended to combine several techniques for best diagnostic gains.

 
  • Literatur

  • 1 Betz CS, Kraft M, Arens C. Optische Diagnoseverfahren zur Tumorfrühdiagnostik im oberen Luft-Speise-Weg. Quo vadis?. HNO 2016; 64: 41-48
  • 2 Zwakenberg MA, Dikkers FG, Wedman J. et al. Narrow band imaging improves observer reliability in evaluation of upper aerodigestive tract lesions. Laryngoscope 2016; 126: 2276-2281
  • 3 Arens C, Vorwerk U, Just T. et al. Fortschritte der endoskopischen Diagnostik von Dysplasien und Karzinomen des Larynx. HNO 2012; 60: 44-52
  • 4 Malzahn K, Dreyer T, Glanz H. et al. Autofluorescence endoscopy in the diagnosis of early laryngeal cancer and its precursor lesions. Laryngoscope 2002; 112: 488-493
  • 5 Arens C, Reussner D, Neubacher H. et al. Spectrometric measurement in laryngeal cancer. Eur Arch Otorhinolaryngol 2006; 263: 1001-1007
  • 6 Kraft M, Betz CS, Leunig A. et al. Value of fluorescence endoscopy for the early diagnosis of laryngeal cancer and its precursor lesions. Head Neck 2011; 33: 941-948
  • 7 Kraft M, Arens C, Betz C. et al. Fluoreszenzbildgebung in der Laryngologie – Physikalische Grundlagen, klinische Anwendung und Studienergebnisse. HNO 2016; 64: 4-12
  • 8 Fostiropoulos K, Arens C, Betz C. et al. Nichtinvasive Bildgebung mittels Autofluoreszenzendoskopie Stellenwert bei der Früherfassung des Kehlkopfkarzinoms. HNO 2016; 64: 13-18
  • 9 Rydell R, Eker C, Andersson-Engels S. et al. Fluorescence investigations to classify malignant laryngeal lesions in vivo. Head Neck 2008; 30: 419-426
  • 10 Gono K. Narrow Band Imaging: Technology Basis and Research and Development History. Clin Endosc 2015; 48: 476-480
  • 11 Masaki T, Katada C, Nakayama M. et al. Narrow band imaging in the diagnosis of intra-epithelial and invasive laryngeal squamous cell carcinoma: a preliminary report of two cases. Auris Nasus Larynx 2009; 36: 712-716
  • 12 Piazza C, Dessouky O, Peretti G. et al. Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. Review of the literature. Acta Otorhinolaryngol Ital 2008; 28: 49-54
  • 13 Irjala H, Matar N, Remacle M. et al. Pharyngo-laryngeal examination with the narrow band imaging technology: early experience. Eur Arch Otorhinolaryngol 2011; 268: 801-806
  • 14 Muto M, Horimatsu T, Ezoe Y. et al. Narrow-band imaging of the gastrointestinal tract. J Gastroenterol 2009; 44: 13-25
  • 15 Schossee A, Voigt-Zimmermann S, Kropf S. et al. Evaluation eines Klassifikationsmodells horizontaler Gefäßveränderungen der Stimmlippen. Laryngorhinootologie 2016; 95: 245-250
  • 16 Pliske G, Voigt-Zimmermann S, Glaßer S. et al. Objective quantification of the vocal fold vascular pattern: comparison of narrow band imaging and white light endoscopy. Eur Arch Otorhinolaryngol 2016; 273: 2599-2605
  • 17 Shoffel-Havakuk H, Lahav Y, Meidan B. et al. Does narrow band imaging improve preoperative detection of glottic malignancy? A matched comparison study. Laryngoscope 2017; 127: 894-899
  • 18 Arens C, Glanz H, Voigt-Zimmermann S. Gefäßveränderungen der Stimmlippen – Teil 2: Perpendikuläre Gefäßveränderungen. Laryngorhinootologie 2015; 94: 738-744
  • 19 Bertino G, Cacciola S, Fernandes Jr WB. et al. Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification. Head Neck 2015; 37: 215-222
  • 20 Kraft. Fostiropoulos K, Gurtler N. et al. Value of narrow band imaging in the early diagnosis of laryngeal cancer. Head Neck 2016; 38: 15-20
  • 21 Bäck LJJ, Rekola J, Raittinen L. et al. The feasibility of NBI in patients with suspected upper airway lesions: A multicenter study. Laryngoscope 2017; 127: 1821-1825
  • 22 De Vito A, Meccariello G, Vicini C. Narrow band imaging as screening test for early detection of laryngeal cancer: a prospective study. Clin Otolaryngol 2017; 42: 347-353
  • 23 Tateya I, Ishikawa S, Morita S. et al. Magnifying Endoscopy with Narrow Band Imaging to Determine the Extent of Resection in Transoral Robotic Surgery of Oropharyngeal Cancer. Case Rep Otolaryngol 2014; 2014: 604737
  • 24 Arens C, Betz C, Kraft M. et al. „Narrow band imaging“ zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg. HNO 2016; 64: 19-26
  • 25 Davaris N, Voigt-Zimmermann S, Roessner A. et al. „Narrow band imaging“ zur Beurteilung laryngealer Schleimhautläsionen. HNO 2017; 65: 527-542
  • 26 Gerstner AO, Martin R, Westermann S. et al. Hyperspectral Imaging in der Kopf-Hals-Onkologie. Laryngorhinootologie 2013; 92: 453-457
  • 27 Liu Z, Wang H, Li Q. Tongue tumor detection in medical hyperspectral images. Sensors (Basel) 2012; 12: 162-174
  • 28 Lu G, Fei B. Medical hyperspectral imaging: a review. J Biomed Opt 2014; 19: 10901
  • 29 Gerstner AOH, Laffers W, Bootz F. et al. Hyperspectral imaging of mucosal surfaces in patients. J Biophotonics 2012; 5: 255-262
  • 30 Laffers W, Westermann S, Regeling B. et al. Früherkennung kanzeröser Läsionen in Oropharynx und Mundhöhle – Automatisierte Evaluation hyperspektraler Bildstapel. HNO 2016; 64: 27-33
  • 31 Burns JA. Optical coherence tomography: imaging the larynx. Curr Opin Otolaryngol Head Neck Surg 2012; 20: 477-481
  • 32 Kraft M, Glanz H, von Gerlach S. et al. Clinical value of optical coherence tomography in laryngology. Head Neck 2008; 30: 1628-1635
  • 33 Volgger V, Girschick S, Ihrler S. et al. Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study. Head Neck 2016; 38: E1695-1704
  • 34 Armstrong WB, Ridgway JM, Vokes DE. et al. Optical coherence tomography of laryngeal cancer. Laryngoscope 2006; 116: 1107-1113
  • 35 Burns JA, Kim KH, deBoer JF. et al. Polarization-sensitive optical coherence tomography imaging of benign and malignant laryngeal lesions: an in vivo study. Otolaryngol Head Neck Surg 2011; 145: 91-99
  • 36 Fomina IuV, Gladkova ND, Leont’ev VK. et al. [Optical coherence tomography in the evaluation of the oral cavity mucosa. Part II. Benign and malignant diseases]. Stomatologiia (Mosk) 2004; 83: 25-32
  • 37 Wilder-Smith P, Lee K, Guo S. et al. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients. Lasers Surg Med 2009; 41: 353-357
  • 38 Volgger V, Stepp H, Ihrler S. et al. Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract. Head Neck 2013; 35: 1558-1566
  • 39 Arens C, Kraft M. Endoscopic ultrasound of the larynx. Curr Opin Otolaryngol Head Neck Surg 2016; 24: 128-134
  • 40 Kraft M, Bruns N, Hügens-Penzel M. et al. Clinical value of endosonography in the assessment of laryngeal cancer. Head Neck 2013; 35: 195-200
  • 41 Kraft M, Arnoux A, Arens C. Ultraschallmikroskopie im oberen Aerodigestivtrakt Erste klinische Erfahrungen. HNO 2011; 59: 366-370
  • 42 Arens C, Piazza C, Andrea M. et al. Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Otorhinolaryngol 2016; 273: 1207-1214
  • 43 Arens C, Voigt-Zimmermann S. Kontaktendoskopie der Stimmlippen in Kombination mit Narrow-Band-Imaging (Kompaktendoskopie). Laryngorhinootologie 2015; 94: 150-152
  • 44 Dittberner A, Rodner E, Ortmann W. et al. Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer. Head Neck 2016; 38: E1419-1426
  • 45 Gerstner AO. Early detection in head and neck cancer – current state and future perspectives. GMS Curr Top Otorhinolaryngol Head Neck Surg 2008; 7: Doc06