Update on hormesis and its relation to homeopathy

Introduction: Hormesis is a dose–response relationship characterized by a biphasic dose response to stressors with a low dose stimulation and a high dose inhibition. The first systematic description of hormesis appeared toward the close of the 18th century by the German pharmacology professor Hugo Schulz. The stressor agent can be any agent or factor capable of causing a deleterious effect. The biological systems can be diverse: bacteria, fungi, algae, yeasts, animals, humans, protozoa and plants. The range of endpoints covers longevity, reproduction, cancer, survival, growth, metabolic effects and others. Hormesis is a nonspecific phenomenon, which can occur in any biological system and can be caused by any stressor. It is quantifiable and reproducible. The apparent similarity between the basic principle of hormesis and homeopathy’s Similia Principle, together with the homeopathic claim that hormesis validates homeopathy caused its marginalization, and its rejection during the past century by central figures in pharmacology. Recent years have seen a slight renaissance in the conventional scientific attitude towards hormesis.

Method: We compared hormesis and homeopathy.

Result: There is no convincing evidence of similarity between these two systems. Moreover, there are several crucial differences between them, which seem to refute any idea that they stem from the same root. This paper discusses these differences. The rejection of hormesis on grounds of its similarity to homeopathy is unjustified.

Conclusion: The authors suggest exploring the differences between both systems. Such exploration may answer the key question of whether they do indeed share a root or embrace the same principles. Such exploration may also spur research within both systems to answer further open questions.

Keywords

Homeopathy - Hormesis - Arndt–Schulz Law - Hueppe’s rule

• References

• 1 Calabrese E.J., Baldwin L.A. Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. Hum Exp Toxicol 2000; 19: 85-97.
• 2 Calabrese E., Baldwin L. Chemical hormesis: its historical foundations as a biological hypothesis. Hum Exper Toxicol 2000; 19: 2-31.
• 3 Calabrese E., Baldwin L. Hormesis: a generalizable and unifying hypothesis. Crit Rev Toxicol 2001; 31: 353-424.
• 4 Henschler D. The origin of hormesis: historical background and driving forces. Hum Exp Toxicol 2006; 25: 347-351.
• 5 Schulz H. Zur Lehre von der Arzneiwirdung. Virchows Arch Pathol Anat Physiol Klin Med 1887; 108: 423-445.
• 6 Schulz H. Ueber Hefegifte. Pflugers Arch Gesamte Physiol Menschen Tiere 1888; 42: 517-541.
• 7 Arndt R. Die Neurasthenie (Nervenschwäche), ihr Wesen, ihre Bedeutung und Behandlung vom anatomisch-physiologischen Standpunkte für Ärzte und Studierende. Wien und Leipzig.; 1885.
• 8 Schulz H. Die Medizin der Gegenwart in Selbstdarstellungen. 1923. F Meixner Verlag; 217-249.
• 9 http://www.nobelprize.org/nomination/archive/show_people.php?id=8263 (last accessed 14 April 2015).
• 10 Hueppe F. The principles of bacteriology. Chicago: The Open Court Publishing Company.; 1896.
• 11 Hueppe F., Jordan E.O. The principles of bacteriology. Chicago: The Open Court Publishing Company.; 1899.
• 12 Calabrese E.J., Baldwin L.A. The marginalization of hormesis. Hum Exp Toxicol 2000; 19: 32-40.
• 13 Bellavite P., Andrioli G., Lussignoli S., Signorini A., Ortolani R., Conforti A. A scientific reappraisal of the ‘principle of similarity’. Med Hypotheses 1997; 49: 203-212.
• 14 Bellavite P. On the plausibility of homeopathic ‘similitude’. Bioethics 2012; 26: 506-507.
• 15 Calabrese E.J. Historical blunders: how toxicology got the dose-response relationship half right. Cell Mol Biol (Noisy-le-grand) 2005; 51: 643-654.
• 16 Clark A.J. Mode of action of drugs on cells. Baltimore, MD: Williams and Wilkins Company.; 1933.
• 17 Clark A.J. Handbook of experimental pharmacology. Berlin: Verlag von Julius Springer.; 1937.
• 18 Kendig E.L., Le H.H., Belcher S.M. Defining hormesis: evaluation of a complex concentration response phenomenon. Int J Toxicol 2010; 29: 235-246.
• 19 Weltje L., vom Saal F.S., Oehlmann J. Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response. Hum Exp Toxicol 2005; 24: 431-437.
• 20 Calabrese E.J., Baldwin L.A. Defining hormesis. Hum Exp Toxicol 2002; 21: 91-97.
• 21 Shackell L.F. Studies in protoplasm poisoning: I. Phenols. J Gen Physiol 1923; 5: 783-805.
• 22 Shackell L.F. The relation of dosage to effect. II. J Pharmacol Exp Ther 1925; 25: 275-288.
• 23 Shackell L.F., Williamson W., Deitchman M.M., Katzman G.M., Kleinman B.S. The relation of dosage to effect. J Pharmacol Exp Ther 1924; 24: 53-65.
• 24 Calabrese E.J. Getting the dose–response wrong: why hormesis became marginalized and the threshold model accepted. Arch Toxicol 2009; 83: 227-247.
• 25 Southam C.M., Ehrlich J. Effects of extracts of western red-cedar heartwood on certain wood-decaying fungi in culture. Phytopathology 1943; 33: 517-524.
• 26 Calabrese E.J. Toxicology rewrites its history and rethinks its future: giving equal focus to both harmful and beneficial effects. Environ Toxicol Chem 2011; 30: 2658-2673.
• 27 Stebbing ARD. Hormesis–the stimulation of growth by low levels of inhibitors. Sci Tot Environ 22:213–234.
• 28 Stebbing A.R.D. A theory for growth hormesis. Belle Newsl 1997; 6: 1-12.
• 29 Rozman K.K., Doull J. Scientific foundations of hormesis. Part 2. Maturation, strengths, limitations, and possible applications in toxicology, pharmacology, and epidemiology. Crit Rev Toxicol 2003; 33: 451-462.
• 30 Luckey T.D., Gordon H.A., Wagner M. et al. Growth of germfree birds fed antibiotics. Antibiot Chemother 1956; 6: 36-40.
• 31 Luckey T.D. Modes of action of antibiotics in growth stimulation. Recent Progr Microbiol 1959; 7: 340-370.
• 32 Calabrese E.J. Hormesis: a fundamental concept in biology. Microb Cell 2014; 1: 145-149.
• 33 Calabrese E.J. Hormesis and medicine. Br J Clin Pharmacol 2008; 66: 594-617.
• 34 Calabrese E.J. Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses. Crit Rev Toxicol 2005; 35: 463-582.
• 35 Calabrese E.J. Hormesis: why it is important to toxicology and toxicologists. Environ Toxicol Chem 2008; 27: 1451-1474.
• 36 Calabrese E.J. Toxicology rewrites its history and rethinks its future: giving equal focus to both harmful and beneficial effects. Environ Toxicol Chem 2011; 30: 1658-1673.
• 37 Calabrese E.J. Evidence that hormesis represents an “overcompensation” response to a disruption in homeostasis. Ecotoxicol Environ Saf 1999; 42: 135-137.
• 38 Calabrese E.J., Blain R. The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview. Toxicol Appl Pharmacol 2005; 202: 289-301.
• 39 Hahnemann S.F.C. Organon of medicine. 6th edn 1970. New Delhi: B. Jain Publishers; 64-65.
• 40 Bernardini S., Dei A. Hormesis may provide a central concept for homeopathy development. Toxicol Appl Pharmacol 2006; 211: 84-85.
• 41 Oberbaum M., Frass M., Gropp C. Unequal brothers. Homeopathy 2015; 104: 97-100.
• 42 http://www.fnal.gov/pub/inquiring/questions/atoms.html (accessed 1 February 2010).
• 43 Dreher J. How many atoms are there in the ‘world’ solar system, & universe? http://www.madsci.org/posts/archives/may98/892502124.Ph.r.htm (accessed 1 February, 2010).
• 44 Kayne S.B. Homeopathic pharmacy: theory and practice. 2nd edn 2006. London, UK: Churchill Livingstone; 5.
• 45 Calabrese E.J., Jonas W. Homeopathy, clarifying its relation to hormesis. Hum Exper Toxicol 2010; 29: 531-536.
• 46 Lux JJW. https://de.wikipedia.org/wiki/Johann_Josef_Wilhelm_Lux.
• 47 Berchieri Jr. A., Turco W.C., Paiva J.B. et al. Evaluation of isopathic treatment of Salmonella enteritidis in poultry. Homeopathy 2006; 95: 94-97.
• 48 Bracho G., Varela E., Fernández R. et al. Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control. Homeopathy 2010; 99: 156-166.
• 49 Banerjee P., Biswas S.J., Belon P. et al. A potentized homeopathic drug, Arsenicum Album 200, can ameliorate genotoxicity induced by repeated injections of arsenic trioxide in mice. J Vet Med A Physiol Pathol Clin Med 2007; 54: 370-376.
• 50 Mallick P., Mallick J.C., Guha B. et al. Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. BMC Complement Altern Med 2003; 22 (03) 7.
• 51 Kundu S.N., Mitra K., Khuda Bukhsh A.R. Efficacy of a potentized homeopathic drug (Arsenicum-Aalbum-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Complement Ther Med 2000; 8: 157-165.