Abadi, Z

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Abdallah, AT

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Ahmadzadehfar, H

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Aigner, E

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Aithal, G

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Alavian, SM

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Albrecht, T

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

Alexandrov, A

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Alexandrov, T

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism

Al-Herwi, E

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Aliabadi, E

Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

Alizor, H

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Allweiss, L

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Al-Mahtab, M

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Alonso-Pena, M

Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M

Alquzi, S

Liver stiffness decreases in response to portal pressure lowering drugs

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Al-Saeedi, M

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Alvarez-Silva, C

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Aly, M

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Amer, W

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Andersen, JB

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Andreas, T

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Angel, P

Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries

Antoni, C

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Appenrodt, B

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Aprupe, L

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Araos, J

How endoglin modulates the hepatocytes' response to BMP-9

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

Arroyo, V

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Artmann, R

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Arumugam, M

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Aschenbrenner, E

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Asen, T

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Ashfaq, I

Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model

Aßmuth, S

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Atkinson, SR

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Augustin, H

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Awad, M

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Baba, HA

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Backhus, J

Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils

Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose

Backu, E

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Badenhoop, K

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Balp, MM

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Bals, R

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Banales, JM

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Bang, C

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Bantel, H

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Barat, S

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Baretton, G

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Barikbin, R

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Barreto, G

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Bartenschlager, R

Identification of host cell factors involved in hepatitis C virus replication

Role of autophagy in hepatitis C virus replication

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Lipid droplets and associated proteins in viral hepatitis

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Bastgen, D

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Bauer, M

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Bauer, T

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Baumann, S

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Baumert, T

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Bazinet, M

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Bazylak-Kapps, B

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Bechmann, L

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Becker, D

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Becker, T

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Bedossa, P

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Beer, B

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Bender, S

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Bendtsen, F

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Benedé-Ubieto, R

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Bengsch, B

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Benjamin, G

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Berg, C

Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)

Berg, T

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Bergen, M von

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Berger, A

Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose

Bergheim, D

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Berkhout, L

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Berres, ML

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Best, J

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Bettinger, D

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Beuers, U

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Bidmon, HJ

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Biedenbach, J

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Bilzer, M

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Binder, H

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Binder, M

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Bockmann, JH

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Bode, JG

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet

Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3

Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM

Boden, K

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

Boettler, T

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Böhm, K

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Böhm, S

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Boor, P

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Bopp, C

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle

Borkham-Kamphorst, E

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses

Bosch, M

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Bösch, F

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Bosserhoff, AK

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis

The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma

Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Bovensiepen, C

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Bowlus, CL

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Branchi, V

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Brandt, EF

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Brass, C

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Breitkopf-Heinlein, K

How endoglin modulates the hepatocytes' response to BMP-9

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

Breuhahn, K

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Brinz, S

Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils

Brodesser, S

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Broering, R

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Bröker, K

Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa

Brooks, J

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Brosch, M

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Bruckmann, A

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Brückner, S

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Brugger, M

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

Brügger, B

Identification of host cell factors involved in hepatitis C virus replication

Brüne, B

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Brunner, SM

Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation

Bruns, T

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Buch, S

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Büchetr, M

Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective

Büchler, MW

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Büchter, M

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Buck, A

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Budczies, J

RSPO2 gene rearrangement – a new cancer driver in the liver

Budeus, B

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Buechler, C

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Buechter, M

Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients

Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience

Buettner, N

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Buettner, R

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Buggisch, P

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Buhl, EM

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Burkhardt, R

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Buti, M

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Büttner, R

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Byrtus, A

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Byrtus, J

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Cai, C

How endoglin modulates the hepatocytes' response to BMP-9

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Cai, J

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Calvisi, DF

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Canbay, A

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Cantz, T

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Carambia, A

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Caruso, S

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Casey, J

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Casillas, R

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Casper, M

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Castven, D

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Chalmers, J

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Chamulitrat, W

iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet

Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism

Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Chatzigeorgiou, A

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Chavakis, T

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Che, L

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Chen, C

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Chen, LS

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Chen, W

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Chen, X

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Cheng, X

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Cheng, Y

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Christ, B

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Christen, U

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Christiansen, N

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Christidis, G

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Chung, KJ

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Churin, Y

CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Ciesek, S

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Cigliano, A

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Claria, J

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Clees, C

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Conrad, C

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Conrad, R

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Cornberg, M

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Coskun, Ü

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Cosma, LS

Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology

Cramer, T

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Cubero, FJ

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Czauderna, C

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Dabere, O

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Dabiri, Y

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Dächert, C

Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Dahl, A

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Dahmen, U

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

Dalvi, P

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

Damm, G

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Dammermann, W

Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa

Dandri, M

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Daniel, S

Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose

Datz, B

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Datz, C

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Davis, RJ

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice

Dejardin, E

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

De Keizer, B

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

De la Torre, C

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Demir, M

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Denk, A

Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology

Denk, G

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

De Ponti, A

Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries

de Toni, E

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Deutschmann, K

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Dewidar, B

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Dietrich, P

The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma

Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Dikopoulos, N

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Ding, H

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Djouder, N

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Dobrikova, K

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Doleschel, D

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Dombrowski, F

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment

Donakonda, S

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Dong, S

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Dooley, S

Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma

Dormann, C

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Dow, LE

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Drasdo, D

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Drebber, U

Lipid droplets and associated proteins in viral hepatitis

Drenth, JPH

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Dries, V

Lipid droplets and associated proteins in viral hepatitis

Dröge, C

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Dropmann, A

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Drucker, E

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Dudek, M

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Duong, S

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Durantel, D

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Duret, D

Steatosis and associated proteins in hepatocellular adenoma

Ebert, MP

Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer

How endoglin modulates the hepatocytes' response to BMP-9

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Ehlken, H

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Ehlting, C

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3

Ehmer, U

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Ehrenmann, P

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Ehrlich, S

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Eischeid-Scholz, H

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Eiteneuer, E

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Elshaarawy, O

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Critical flicker frequency improves after alcohol abstinence

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Emmerich, F

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Endris, V

RSPO2 gene rearrangement – a new cancer driver in the liver

Erdem, M

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Erlangga, Z

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Ernst, I

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Essler, M

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Estévez Vázquez, O

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Evert, K

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Evert, M

Hepamine 2.0

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Eyer, F

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Falk, CS

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Fan, W

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Fatima, S

Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model

Fauvelle, C

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Feder, S

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Felden, J von

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Felkel, C

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Feng, R

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Ferreirós, N

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Fichtner-Feigl, S

Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Figura, G von

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Finkelmeier, F

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Finnemann, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Fischer, HP

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Fischer, J

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Fischer, MMJ

Lysophosphatidic acid activates peripheral glial cells

Fischer, P

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Fischer, S

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Fitting, D

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Flecken, T

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Florian, R

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Forman, LM

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Fragoulis, A

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Franck, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Frank, A

Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)

Franke, A

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Freese, K

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis

Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Fricker, G

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Friess, H

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Frishman, D

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

HDVdb: Hepatitis D virus database

Frissen, M

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Fritz, V

The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Fromme, M

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Gaestel, M

Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3

Gagliani, N

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Gaitantzi, H

How endoglin modulates the hepatocytes' response to BMP-9

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

Gajowski, R

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Gal, FL

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Gallage, S

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Gallati, S

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Galle, PR

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Galvez, EJC

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Gandraß, M

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Gan-Schreier, H

iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet

Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism

Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Gänssler, JM

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Ganzha, A

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Gargani, S

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Gasparoni, G

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Gassler, N

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Gaßner, J

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Gavaghan, M

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Gawaz, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Gaza, A

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Gebhardt, L

Lysophosphatidic acid activates peripheral glial cells

Gebhardt, R

The interactions of Hedgehog and mTor signaling in Hepatocytes

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Geffers, R

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Gehrke, N

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Geier, A

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Geisslinger, G

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Genesca, J

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Gerardy-Schahn, R

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Gerbes, AL

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Gerken, G

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients

Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Gertzen, C

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Ghallab, A

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Ghamarnejad, O

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

GhamarNejad, O

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Ghamar Nejad, O

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Ghennam, E

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

Giersch, K

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Giesler, M

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Gillich, N

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Glebe, D

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Gluud, LL

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Goeppert, B

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Goeser, F

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Goeser, T

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Goetze, O

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Gohlke, H

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Golriz, M

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Goltz, D

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Gordan, J

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Gordien, E

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Görg, B

Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Gostick, E

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Gotter, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Gottfried-Brand, D

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Gotthardt, D

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Götze, O

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Gould, K

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Gozdowska, J

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Grandt, D

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Grandt, J

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Greinert, R

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Gremse, F

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Gretz, N

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Grevelding, CG

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Grewe, I

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Griffiths, WJH

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Grimminger, P

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Groth, S

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Grove, J

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Grünhage, F

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Grzybek, M

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Gschwendter, H

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Gschwendtner, H

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Gu, Z

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Guenther, V

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Guha, IN

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Guldiken, N

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Gülow, K

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Gunda, M

Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels

Guo, F

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Gürlevik, E

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Guthke, R

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Guttmann, S

SERPINA1 levels dictate TTR expression in HepG2 cells

Haas, U

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Haberl, EM

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Haderer, M

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Hagel, C

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Haifeng, X

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Hall, RA

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Haller, D

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Hamesch, K

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Hammad, S

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Hampe, J

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Han, M

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Hanenberg, H

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Hardtke, S

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Harris, R

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Harten, M von

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Hartl, J

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Hartmann, D

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Hartmann, H

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Hartmann, M

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Hartmann, N

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Hartwig, V

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Hassan, R

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Hatting, M

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Haupts, A

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Häussinger, D

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3

Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Haybaeck, J

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Healy, M

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Heeren, J

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Heide, D

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Heikenwälder, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Heilmann-Heimbach, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Heim, K

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Heimes, CV

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Heine, K

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Heinold, A

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Heinrich, F

The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis

The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells

Heinrich, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Steatosis and associated proteins in hepatocellular adenoma

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Heinrichs, D

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Heinsen, FA

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Heintz, L

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Heinzow, H

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Hellerbrand, C

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis

The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma

Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Helm, F

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Hempel, M

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Hendricks, L

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Hengstler, JG

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients

Hennings, J

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

Hensel, N

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Herkel, J

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Hermanns, HM

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M

Hermanussen, L

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Herpel, E

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Herrera Gonzalez, BM

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Herrmann, A

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Heyne, R

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Hinrichsen, H

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Hippchen, T

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis

Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

Hochrath, K

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Hoffmann, D

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Hoffmann, K

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Hoffmeister, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Hofmann, M

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Hofmann, U

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Hofmann, WP

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Hohenester, S

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Höhme, S

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Holland, C

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Holz, R

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Holzer, K

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Hooiveld, GJ

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Hoppmann, H

TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis

Horner, R

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Horst, AK

Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation

Horst, D

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Hou, J

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Howe, T

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Hsu, MJ

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids

Hu, X

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Huang, J

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Hübbers, A

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Huber, M

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Huber, S

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Huber, Y

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Hueser, N

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Hüser, N

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Ibidapo-obe, O

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Imiela, CS

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Ingiliz, P

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Inverso, D

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Irungbam, K

CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice

Ishaque, N

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Itzel, T

Hepamine 2.0

Jacobi, F

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Jacobs, S

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Jäger, M

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Jakubowski, S

Steatosis and associated proteins in hepatocellular adenoma

Janciauskiene, S

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Jankowska, I

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Jankowski, K

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Jansen, C

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Janssen, H

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Ji, J

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Jia, J

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Jin, Y

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Jöchle, K

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

John, C

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Jordan, S

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Jördens, MS

Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Jud, A

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Jumpertz, S

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Jung, J

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Junger, H

Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation

Junghanss, T

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Kaderali, L

Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma

Kah, J

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Kahraman, A

Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective

Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients

Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Kaiser, K

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Kalkhof, S

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Kallin, N

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Kamlage, B

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Kanitz, V

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Kantowski, M

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Karagoz, E

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Karatayli, E

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Karatayli, SC

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Karimzadeh, H

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

HDVdb: Hepatitis D virus database

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Karsdal, M

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Kasper, P

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Kather, JN

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Kattler, K

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Kauer, L

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kaufmann, B

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Keitel, V

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Kellerer, M

Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation

Kemming, J

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Kemper, T

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Kern, L

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Kersting, S

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Khajeh, E

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Kickuth, R

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Kiessling, F

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Kim, P

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Kimer, N

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Kiraithe, M

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Kircher, M

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Kirchner, M

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Klausen, G

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Kleeschulte, S

Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet

Klein, I

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Klein, R

Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)

Klingmüller, U

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

Klinker, H

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Klopp, A

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Klöters-Plachky, P

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Klotz, S

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Kluge, M

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Kluwe, J

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Knight, A

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Knolle, PA

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Ko, C

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Koch, A

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Koch, M

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Koczulla, R

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Kohlhepp, M

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Köhncke, J

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Kohnke-Ertel, B

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Kolbe, E

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

König, V

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Kontoyiannis, D

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Kook, L

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Koop, A

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Korte, I

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Koschny, R

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Köse, N

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Kotsiliti, E

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Krabbe, V

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Kraft, ARM

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

Krag, A

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Krämer, B

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Kratochvil, I

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Krawczak, M

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Krawczyk, M

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Kremer, AE

Lysophosphatidic acid activates peripheral glial cells

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Kriegsmann, M

RSPO2 gene rearrangement – a new cancer driver in the liver

Kristiansen, G

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Kriz, M

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kroy, DC

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

Krstic, T

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

Kubes, P

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Kubicka, S

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Kücükoglu, Ö

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Kudlich, T

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Kueppers, A

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Kuhn, M

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Kühn, H

Lysophosphatidic acid activates peripheral glial cells

Kühne, H

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Kühnel, F

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Kummer, U

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Kunst, C

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Kunzmann, L

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kurz, S

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

Kütting, F

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Lam, M

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Lambertz, D

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Lammers, T

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Lammert, F

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Lam Wai-Ling, M

Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries

Lan, S

Critical flicker frequency improves after alcohol abstinence

Lang, A

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Lang, H

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Lang, J

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Lang, KS

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Lang, P

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

Lang, PA

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Lang, S

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Lang, SA

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Lange, C

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Lange, CM

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Langholm, L

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Langlotz, M

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Lapa, C

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Laschinger, M

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Laschtowitz, A

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Laszik, Z

Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation

Lattanzi, B

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Latz, E

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Lebensztejn, D

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Lechler, C

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Lederer, P

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

Lederle, W

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Lee, S

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Lee, SH

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Lee, SML

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Leeming, D

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Lehmann, J

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Lehmann, R

The interactions of Hedgehog and mTor signaling in Hepatocytes

Lelouvier, B

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Lempp, FA

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Leone, V

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Lerch, MM

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Lesche, M

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Levy, M

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Li, H

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Li, X

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Liao, L

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Liberman, A

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Lichtenberger, J

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Lickei, H

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Liebe, R

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Liebig, S

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Liebisch, G

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Liedtke, C

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Lieshout, R

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Lin, T

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Liu, C

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Liu, K

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Liu, T

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Liwinski, T

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Llewelly-Laceys, S

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Llovet, JM

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Loeffler, MA

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Löhr, J

Thrombelastometry in patients with acute-on-chronic liver failure

Lohse, AW

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Longerich, T

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

RSPO2 gene rearrangement – a new cancer driver in the liver

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Lotter, H

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Lu, K

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Lu, M

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Lucifora, J

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Lücke, K

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Ludwig-Portugall, I

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Luedde, T

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Luis, ZRL

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Luo, X

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Lurje, G

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Lütgehetmann, M

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Lüth, S

Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa

Lütjohann, D

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Lutz, P

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Luxenburger, H

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Maasoumy, B

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

MacConell, L

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Macheleidt, I

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

Macpherson, A

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Madsen, BS

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Magdaleno, F

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Mahli, A

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Mahn, F

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Maiju, M

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Main, N

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Majlesara, A

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Malehmir, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Malo, A

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Mandorfer, M

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Manekeller, S

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Manka, P

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Manmadhan, S

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Manns, MP

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Manon-Jensen, T

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Manske, K

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Marhenke, S

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Markovic, J

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Marquardt, J

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Marquardt, JU

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Marschall, HU

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Martin, A

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Marx, A

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Matteo, M

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Matthias, E

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Matz-Soja, M

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

The interactions of Hedgehog and mTor signaling in Hepatocytes

Loss of zonation in end stage liver disease revealed by in situ omics

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Mayerle, J

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Mayr, D

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

McKenna, SJ

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

McQuillin, A

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Mehrabi, A

RSPO2 gene rearrangement – a new cancer driver in the liver

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Meierhofer, D

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Meindl-Beinker, NM

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Melter, M

Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Menzel, M

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Merle, U

Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism

Thrombelastometry in patients with acute-on-chronic liver failure

Merli, M

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Mertens, A

Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Messerschmidt, I

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Mester, PI

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Metzendorf, C

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment

Meyer, C

Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma

Micali, G

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Michael, T

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Michaelis, J

Thrombelastometry in patients with acute-on-chronic liver failure

Michalski, M

Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion

Michels, B

TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis

Michler, T

Estimation of the genotype distribution within global chronic hepatitis B virus infections

Mijočević, H

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Milkiewicz, M

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Milkiewicz, P

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Ming, T

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Ming, Y

iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet

Miravitlles, M

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Mirtschink, P

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Mitroulis, I

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Mittrücker, HW

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Mix, C

Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

Möbus, S

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Möckel, D

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Moeller, LS

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Mogler, C

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Mohamed, MR

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice

Mohammadikhajehdehi, S

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Mohs, A

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Möller, S

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Mondorf, A

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Monga, SP

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Moolenaar, W

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Moosburner, S

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Morgan, MY

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Morgül, H

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Moser, V

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Muche, M

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Mücke, MM

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Muders, M

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Mueller, J

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Critical flicker frequency improves after alcohol abstinence

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Mueller, S

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Critical flicker frequency improves after alcohol abstinence

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Müller, M

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Müller-Schilling, M

Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology

TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Mutz, P

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Møller, S

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Nahon, P

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Nassal, M

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Nati, M

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Nattermann, J

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Naumann, U

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Neeff, HP

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Nehring, S

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Neuber, S

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Neuhaus, K

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Neumann, A

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Neumann, K

The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis

The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Neumann, O

RSPO2 gene rearrangement – a new cancer driver in the liver

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Neumann-Haefelin, C

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Neuwirth, A

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Nevzorova, YA

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Ni, Y

IFN response suppresses HDV persistence during hepatocytes proliferation in vitro

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Nickkholgh, A

Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy

Nicklas, A

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle

Nielsen, MJ

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Niemann, J

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Niemietz, C

SERPINA1 levels dictate TTR expression in HepG2 cells

Nierhoff, D

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

Nieswandt, B

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Niewiadomska, O

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Nikdad, M

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma

Nimanong, S

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Nischalke, HD

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Nkongolo, S

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Nordheim, A

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Nordström, K

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Nürnberger, V

Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment

Nwosu, ZC

Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma

O'Connor, T

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

O'Rourke, C

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Oberhardt, V

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Ochel, A

The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis

The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells

Ocker, M

CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice

Odenthal, M

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Oleksiuk, O

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Oppermann, H

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Ori, A

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Ostroumov, D

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Othman, A

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

Ott, F

The interactions of Hedgehog and mTor signaling in Hepatocytes

Ott, JJ

Estimation of the genotype distribution within global chronic hepatitis B virus infections

Ott, M

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Otto, AC

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Oude Elferink, R

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Padem, S

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Palladini, A

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Pampaloni, F

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Pandyra, AA

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Pannicke, N

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Panning, M

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Pape, UF

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Parés, A

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Park, YN

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Parsberg Werge, M

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Pascher, A

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Paukstat, K

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort

Paul, A

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Paul, D

Identification of host cell factors involved in hepatitis C virus replication

Role of autophagy in hepatitis C virus replication

Pavel, M

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Pawelka, K

Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation

Pawella, LM

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Pearce, EL

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Peccerella, T

Liver stiffness decreases in response to portal pressure lowering drugs

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Pecerella, T

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Peiseler, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Pellegrino, R

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Pencek, R

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Peng, J

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Pereira, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Pereira, V

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Peuker, K

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Pfaff, L

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Pfeffer, K

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Pfefferkorn, M

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Pfister, D

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Philip, B

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Philippski, P

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Pichlmair, A

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Piecha, F

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Piekorz, R

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

Pieper, C

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Pigliacelli, A

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Piiper, A

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Pikarsky, E

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Pinna, F

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Pinter, M

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Pinyol, R

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Pioronska, W

Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer

PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma

Pischke, S

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa

Pleli, T

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Poch, T

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Pockros, PJ

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Pohl, J

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Pohl, R

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Pohlmann, A

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Pollinger, K

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion

Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma

Polz, R

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Pons, M

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Poplawski, A

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Poppenborg, F

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle

Poth, T

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Praktiknjo, M

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Pratschke, J

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Preti, M

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Preuß, B

Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)

Price, DA

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Prinz, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Prokosch, S

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Protzer, U

HDVdb: Hepatitis D virus database

Estimation of the genotype distribution within global chronic hepatitis B virus infections

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Przybysz, R

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Puchas, P

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Pulé, M

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Pusch, S

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Qiao, Y

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Quack, T

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Queck, A

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Quickert, S

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

Raabe, J

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Rad, R

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Rahbari, N

Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma

Ramadori, P

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Rappez, L

Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism

Raschzok, N

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Rasech, S

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Rasenack, J

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Rath, D

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Ratziu, V

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Rau, M

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Rausch, V

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Critical flicker frequency improves after alcohol abstinence

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels

Ravichandran, G

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Raziorrouh, B

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Real, CI

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Recklinghausen, I von

Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

Regel, I

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Rehman, A

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Reich, M

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Reichel, F

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Reichert, AS

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Reichert, MC

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Reike-Kunze, M

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Rein-Fischboeck, L

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Reisinger, F

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Reißing, J

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Reiter, FP

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Rempel, E

RSPO2 gene rearrangement – a new cancer driver in the liver

Reuken, P

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Reuken, PA

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

Reuter, A

Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2

Ribback, S

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment

Rickert, A

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Ridder, DA

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Riedl, T

Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B

Riepl, J

Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Rinella, M

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Ripoll, C

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Rißel, M

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Ritz, TP

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Robering, J

Lysophosphatidic acid activates peripheral glial cells

Röcken, C

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Rockstroh, J

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Röder, C

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Roderburg, C

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Roderfeld, M

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Rodríguez-Frías, F

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Roeb, E

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Roessler, S

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Roggendorf, M

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

HDVdb: Hepatitis D virus database

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Rösch, T

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Rose, M

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

Rose-John, S

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Rosen, D

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Rosenblatt, M

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Rosendahl, J

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Rosenwald, A

RSPO2 gene rearrangement – a new cancer driver in the liver

Rösner, T

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Rössle, M

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Rössler, S

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Roth, W

Lipid droplets and associated proteins in viral hepatitis

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Steatosis and associated proteins in hepatocellular adenoma

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Roy, S

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Ruf, J

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Rufinatscha, K

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

Rühlemann, MC

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Rupp, C

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis

Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Rüschenbaum, S

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Ryan, E

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Ryan, P

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Ryder, S

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Sabagh, M

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Saborowski, A

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Saborowski, M

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Saez-Rodriguez, J

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Sage, J

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Sahin, H

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Sakin, V

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Salimi Alizei, E

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Sànchez Munoz, A

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Sandfort, V

SERPINA1 levels dictate TTR expression in HepG2 cells

Sauer, IM

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Sauer, P

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Sauerbruch, T

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Schaarschmidt, V

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Schachschal, G

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Schäfer, J

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Schafmayer, C

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Schakat, M

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Schattenberg, JM

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Schatz, P

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Schelbert, S

Lipid droplets and associated proteins in viral hepatitis

Scheller, J

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Scherm, S

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Schierwagen, R

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Schilcher, K

Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Schiller, F

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Schilling, M

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Schindeldecker, M

Lipid droplets and associated proteins in viral hepatitis

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Schirmacher, P

Lipid droplets and associated proteins in viral hepatitis

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

RSPO2 gene rearrangement – a new cancer driver in the liver

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Schlaak, J

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Schlattjan, M

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Schlitt, HJ

Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Schlosser, S

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients

Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?

Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?

Schlue, J

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Schmid, RM

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Schmid, S

Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology

TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis

Schmidt, A

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Schmidt, H

SERPINA1 levels dictate TTR expression in HepG2 cells

Schmidt-Arras, D

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Schmiel, M

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Schmithals, C

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Schmitt, J

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Schmitt, V

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Schmitt-Graeff, A

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Schneider, A

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Schneider, C

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Schneider, KM

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Schneller, D

Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries

Schnieders, A

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Schnitzler, P

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Schocknecht, T

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Scholtis, A

Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Schöneweis, K

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Schönfels, W von

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Schott, T

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

Schramm, C

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Schubert, K

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Schubert, L

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Schuch, A

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Schulte, S

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

Schultheiss, M

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Schulz, L

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Schulze, F

RSPO2 gene rearrangement – a new cancer driver in the liver

Schulze-Osthoff, K

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Schulze-Pellengahr, S

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Schulze zur Wiesch, J

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Schumacher, N

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Schwarze-Zander, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Schwarzkopf, K

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Schwarzkopf, KM

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Schweinoch, D

Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma

Schwenzer, J

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Schwinge, D

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Schwittai, I

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Sebastian, M

Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels

Sebode, M

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Seddek, A

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Seebach, J

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Seehawer, M

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Seehofer, D

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Seeßle, J

Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism

Thrombelastometry in patients with acute-on-chronic liver failure

Seitz, HK

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Critical flicker frequency improves after alcohol abstinence

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Seitz, T

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Seufferlein, T

Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils

Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose

Shackel, N

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Shafiei, S

The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Shang, R

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Shao, C

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Sharma, AD

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Functional microRNA screening to improve hepatocyte formation via direct reprogramming

Sharma, R

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Sheikh, N

Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model

Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model

Silva, I

Liver stiffness decreases in response to portal pressure lowering drugs

Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development

Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis

Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels

Simon, KG

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Simon, P

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Singer, S

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Singh, I

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Sinha, A

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Smedile, A

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Smits, M

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Socha, P

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Soehnlein, O

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Sollors, J

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Sommer, J

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Song, X

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Sonntag, R

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Sörensen, A

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Sowa, JP

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Spengler, U

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Spielberg, S

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Spirk, M

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Spitzley, S

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression

Spivak, I

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Spormann, L

The interactions of Hedgehog and mTor signaling in Hepatocytes

Springer, J

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

Stadler, M

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism

Stallmach, A

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Stancu, O

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Stefanescu, H

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Steffen, HM

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Steiger, K

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Stein, K

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Stein, S

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Steinebrunner, N

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Stellmacher, F

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Stengel, S

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Stenzinger, A

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome

RSPO2 gene rearrangement – a new cancer driver in the liver

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Stewart, S

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Stickel, F

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Loss of zonation in end stage liver disease revealed by in situ omics

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Stindt, J

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Stindt, S

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression

Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β

Stoehr, A

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Stojkovic, M

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Stöpel, C

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Strand, D

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

Strand, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Strassburg, CP

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Straub, BK

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Lipid droplets and associated proteins in viral hepatitis

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Steatosis and associated proteins in hepatocellular adenoma

RSPO2 gene rearrangement – a new cancer driver in the liver

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Stremmel, W

Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Strigli, A

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Strnad, P

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Stroszczynski, C

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Strowig, T

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Strücker, B

Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching

Sturm, L

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Su, H

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Subramanian, P

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Sun, B

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Sundaram, B

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Superti-Furga, G

Identification of host cell factors involved in hepatitis C virus replication

Sureau, C

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Surewaard, BGJ

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Svetlana, H

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Sydor, S

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Syn, WK

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

Szydlowska, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Tabata, K

Identification of host cell factors involved in hepatitis C virus replication

Role of autophagy in hepatitis C virus replication

Tacke, F

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Tao, J

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Tauber, C

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Tayyeb, A

Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model

Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model

Techritz, N

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Teresa, P

Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels

Terracciano, L

Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy

Teufel, A

Hepamine 2.0

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Teusel, M

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Thangapandi, RV

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Thasler, WE

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes

Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Thavamani, A

The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC

Theurl, I

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Thiele, M

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Thimme, R

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Thodou, V

Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective

Thomann, S

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Thomas, D

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Thorgeirsson, SS

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Thursz, MR

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Tiegs, G

The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis

The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation

Timm, J

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Timmer, J

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction

Toex, U

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

Tolkach, Y

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Tóth, M

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Touma, M

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

To Vinh, M

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Tran, L

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Trauner, M

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Trautwein, C

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Trebicka, J

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Treckmann, J

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Treitl, M

Varizenblutung oder Aszites: Was bewirkt den Unterschied?

Tremmel, R

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Trippler, M

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Tschuschner, A

Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten

Tu, T

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Tuma-Kellner, S

iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet

Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Tumanov, AV

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Twu, WI

Role of autophagy in hepatitis C virus replication

Uerlings, R

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Uhrig, S

RSPO2 gene rearrangement – a new cancer driver in the liver

Unger, K

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Urban, C

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Urban, S

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

IFN response suppresses HDV persistence during hepatocytes proliferation in vitro

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Uschner, FE

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Usman, Z

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

HDVdb: Hepatitis D virus database

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Utpatel, K

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Vaillant, A

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol

Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays

Valenti, L

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

van Bömmel, F

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B

van Bremen, T

Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Van de Leur, E

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses

van der Kroft, G

An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia

van der Laan, L

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Vehreschild, MJGT

Compartmentalization of immune response and microbial translocation in decompensated cirrhosis

Velkov, S

Estimation of the genotype distribution within global chronic hepatitis B virus infections

Verstegen, M

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Vilchez-Vargas, R

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Villa, M

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Vinnemeyer, C

Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa

Viveiros, A

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Vlaic, S

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Vogel, A

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Vogel, K

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Voitl, R

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis

Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Volz, TK

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Vucur, M

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Wagner-Golbs, A

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Wahlström, A

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Waidmann, O

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Waisman, A

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Walter, J

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Loss of zonation in end stage liver disease revealed by in situ omics

Wammers, M

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Wan, S

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Wandrer, F

Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Wandt, N

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Wang, B

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Wang, J

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Wang, L

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Wang, P

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Wang, S

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Ware, CF

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Weber, A

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Weber, SN

Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Weber, T

Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Weber, TF

RSPO2 gene rearrangement – a new cancer driver in the liver

Wedemeyer, H

Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)

The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients

Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients

Wehmeyer, MH

Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)

Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion

Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie

Wei, X

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Weidemann, S

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Weigert, A

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Weiler, SE

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Weiler, SME

TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice

Weiler-Normann, C

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Weinmann, A

Lipid droplets and associated proteins in viral hepatitis

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Weiskirchen, R

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Weiskirchen, S

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Weiss, J

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Weiss, KH

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis

Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

RSPO2 gene rearrangement – a new cancer driver in the liver

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Weiss, TS

Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC

Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation

Welsch, C

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Welsch, H

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Weng, HL

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Wenning, C

Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker

Werner, M

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Wettengel, J

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Widera, M

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Wiecek, S

Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children

Wiek, C

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Wieland, D

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Wild, K

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Wilhelm, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection

Wilhelm, D

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Willuweit, K

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Wimmer, R

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Wineberger, K

Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)

Wingerath, J

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Winkler, F

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Winkler, S

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Wirth, TC

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Wirtz, TH

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Wisskirchen, K

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Witt, A

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Witte, V

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Witzel, HR

Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3

Wohlleber, D

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis

Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted

Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Woitok, MM

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Wolf, K

Lysophosphatidic acid activates peripheral glial cells

Wolf, S

Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM

Wolff, K

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Wölfl, S

Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma

Woller, N

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins

Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma

Wolters, F

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

Wong, HY

Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress

Wormser, L

Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma

Wörns, M

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Wörns, MA

Steatosis and associated proteins in hepatocellular adenoma

Wöstemeier, A

Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Wunderlich, T

A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver

Wupperfeld, D

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Xiao, Y

MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Xu, M

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Ye, L

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Yin, Y

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Yu, X

Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma

Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis

MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells

Yuan, X

Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure

Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis

Yurdaydin, C

A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection

Zamboni, N

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Zaza, A

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Zehe, S

Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Zehnder, B

Hepatitis B virus (HBV) DNA integration is not driven by viral proteins

Zeissig, S

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Loss of zonation in end stage liver disease revealed by in situ omics

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Zender, L

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Zenouzi, R

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Zenzusi, R

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Zeuzem, S

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)

Zhan, T

Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review

Zhang, X

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Zhang, Z

IFN response suppresses HDV persistence during hepatocytes proliferation in vitro

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Zhang-Hagenlocher, C

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis

Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Zhao, G

Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury

Zhao, J

CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults

Zheng, K

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice

Zhivkova, N

Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma

Zhu, X

iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet

iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes

Zhuang, Y

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Ziesch, A

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Zimmermann, A

Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3

Zimmermann, HW

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Zimmermann, M

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia

Zimmermann, P

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Ziol, M

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Zipprich, A

Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten

Zizer, E

Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils

Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose

Zoldan, K

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells

Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

Zoller, H

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Zopf, S

Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Zoubek, ME

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Zucman-Rossi, J

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Zweerink, S

The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?

Zwerina, J

Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis