Int Arch Otorhinolaryngol 2013; 17(01): 014-019
DOI: 10.7162/S1809-97772013000100003
Original Article
Thieme Publicações Ltda Rio de Janeiro, Brazil

Nasopharyngeal angiofibroma: Our experience and literature review

Mariane Barreto Brandão Martins
1   Resident Doctor in the Department of Otolaryngology of the Federal University of Sergipe.
,
Francis Vinicius Fontes de Lima
1   Resident Doctor in the Department of Otolaryngology of the Federal University of Sergipe.
,
Carlos Alberto Mendonça
2   Professor in the Department of Head and Neck Surgery.
,
Eduardo Passos Fiel de Jesus
3   Professor in the Department of Otolaryngology.
,
Arlete Cristina Granizo Santos
3   Professor in the Department of Otolaryngology.
,
Valéria Maria Prado Barreto
4   Masters in Health Sciences, Universidade Fedreral de Sergipe. Professor in the Department of Otolaryngology.
,
Ronaldo Carvalho Santos Júnior
5   Doctor of Medicine by USP. Service chief medical residency in Otorhinolaryngology, Universidade Federal de Sergipe.
› Author Affiliations
Further Information

Publication History

21 August 2012

07 October 2012

Publication Date:
06 January 2014 (online)

Summary

Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly vascular, and histologically benign tumor, generally observed in male adolescents. It shows very aggressive behavior due to local invasiveness and is associated with various symptoms. Juvenile nasopharyngeal angiofibroma originates in the sphenopalatine forame, causing epistaxes and nasal obstruction.

Objective: To retrospectively describe our experience in the diagnosis and treatment of patients with juvenile nasopharyngeal angiofibroma.

Scientific drawing: Retrospective, descriptive study conducted after approval from the Ethics Committee of the Federal University of Sergipe (protocol 0114.0.107.000 -11).

Methods: We analyzed findings in 20 patients who underwent surgery between 2004 and 2011. Factors analyzed include patient age and gender, symptoms, stages, treatment, length of surgery, intraoperatory bleeding, postoperative need for nasal tampons, hospitalization time, complications, and tumor recurrence.

Results: Patients were aged 10–29 years. All patients were treated surgically, including 17 who underwent endoscopic surgery. The mean operation time was 120 min, and the mean bleeding volume was 300 mL. Seventeen patients required clamping of the external carotids and tumor embolization.

Conclusion: Endoscopic surgery alone or with other conventional techniques was safe for the treatment of angiofibromas of different stages.

 
  • References

  • 1 Mena CC, Bogado GR, Klassen CZ. Nuestra experiência em los últimos 10 anos y revisión de La literatura. An ORL Méx 2009; 69: 243-8
  • 2 Gaeta MM. Nasoangiofibroma juvenil frecuencia. Incidencia de acuerdo a grupo sanguíneo. An ORL Méx 2005; 50: 17-21
  • 3 Wylie JP, Slevin NJ, Johnson RJ. Intracranial juvenile nasopharyngeal angiofibroma. Clin Oncol 1998; 10: 330-3
  • 4 Sanchez de Guzman G. Experiencia en el manejo de nasoangiofibroma juvenil en el Instituto Nacional de Cancerología. Arch Otolaryngol Head Neck Surg 1999; 27 (3) 653-6
  • 5 Sociedade Brasileira de Otorrinolaringologia. Tratado de otorrinolaringologia. 2 Ed. São Paulo: Roca Biomedicina; 2003. . p.701
  • 6 Dillard DG, Cohen C, Muller S, Del Gaudio J, Reichman O, Parrish B , et al. Immunolocalization of Activated Transforming Growth Factor 1 in Juvenile Nasopharyngeal Angiofibrom. Arch Otolaryngol Head Neck Surg 2000; 126: 723-5
  • 7 Mcafee WJ, Morris CG, Andur RJ, Werning JW, Mendenhall WM. Definitive Radiotherapy for Juvenile Nasopharyngeal Angiofibroma. Am J Clin Oncol 2006; 29: 168-70
  • 8 Pryor SG, Moore EJ, Kasperbauer JL. Endoscopic versus Traditional Approaches for Excision of Juvenile Nasopharyngeal Angiofibroma. Laryngoscope 2005; 115: 1201-7
  • 9 Carvalho Júnior RS, Mendonça CA, D'Ávila JS, Santos ACG, Jesus EPF, Sobral PM. Abordagem endoscópica no tratamento do nasoangiofibroma: relato de caso. Braz J Otorhinolaryngol 2005; 71 (3) 4-19
  • 10 Bernal-Sprekelsen M, Alobid I, Guilemany JM. Angiofibroma Juvenil. Acta Otorrinolaryngol 2007; 58 (1) 84-95
  • 11 Hervé S, Portier F, Chapot R. Fibroma Nasofaríngeo. Encyclopedie Medico-Chirurgicale-Otorrinolaringologia 2001- E-20-585-A-10.
  • 12 Luiz ACR, Romualdo SLT, Fava AS. Angiofibroma nasofaríngeo: revisão de literatura. Braz J Otorhinolaryngol 2003; 69 (3) 394-03
  • 13 Alves FRA, Granato L, Maia MS. Acessos Cirúrgicos no Angiofibroma Nasofaríngeo Juvenil - Relato de caso e revisão de literatura. Arch Otolaryngol Head Neck Surg 2006; 10 (2) 162-6
  • 14 Enepekides DJ. Recent advances in the treatment of juvenile angiofibroma. Arch Otolaryngol Head Neck Surg 2004; 12: 495-9
  • 15 Ferreira LMBM, Gomes EF, Azevedo JF. Ressecção Endoscópica de Nasoangiofibroma. Braz J Otorhinolaryngol 2006; 72 (4) 475-80
  • 16 Nicolai P, Berlucchi M, Tomenzoli D. Endoscopic Surgery for Juvenile Angiofibroma: When and How. Laryngoscope 2003; 113: 775-82
  • 17 Maurice M, Milad M. Pathogenisis of Juvenile Nasopharyngeal Fibroma (A new concept). Braz J Otorhinolaryngol 1981; 95: 1121-26
  • 18 Andrade NA, Pinto JA, Nóbrega MO. Exclusively Endoscopic Surgery for Juvenile Nasopharyngeal Angiofibroma. Arch Otolaryngol Head Neck Surg 2007; 137: 492-6
  • 19 Gusso JL, Souza RP, Rapoport A. Nasoangiofibroma Juvenil: concordância interobservadores no estadiamento por tomografia computadorizada. Radiol Bras 2001; 34 (4) 207-11
  • 20 Alborno T, Hofmann TH, Stammberger H. Endoscopic Ressection of Juvenile Angiofibroma: Long term results. Rev JRMS 2005; 12 (2) 18-24
  • 21 Mair EA, Battiata A, Casler JD. Endoscopic Laser-assisted excision of juvenile nasopharyngeal angiofibromas. Arch Otolaryngol Head Neck Surg 2003; 129: 454-9
  • 22 Yotakis I, Eleftheriadou A, Davilis D. Juvenile Nasopharyngeal Angiofibroma stages I and II: A comparative study of surgical approches. Int J Pediatr Otorhinolaryngol 2008; 72: 793-800
  • 23 Mann WJ, Jecker P, Amedee RG. Juvenile Angiofibromas: changing surgical concept over the last 20 years. Laryngoscope 2004; 114: 291-3
  • 24 Neel HB, Whicker JH, Devine KD. Angiofibroma – rewiew of 120 cases. Am J Surg 1973; 126: 547-56
  • 25 Brenner JW, Neel HB, De Santo LW, Jones GC. Angiofibroma: Treatment trends in 150 patients during 40 years. Laryngoscope 1986; 96: 1321-9
  • 26 Tran BHP, Borsik M, Hermam P, Wasser M, Casasco A. Direct intratumoral embolization of juvenile angiofibroma. Am J Otolaryngol 1994; 15: 429-35
  • 27 Sekhar LN, Janecka IP. Surgery of cranial base tumors. New York: Raven Press; 1993. . p.485.
  • 28 Ferreira LHBM, Gomes EF, Azevedo JF, Souza JRF, Araujo RP, Rios ASN. Ressecção endoscópica de nasoangiofibroma. Braz J Otorhinolaryngol 2006; 72: 475-80
  • 29 Katsiotis P, Tzortzis G, Karaminis C. Transcatheter arterial embolization in nasopharyngeal angiofibroma. Acta Radiol Diagn 1979; 20 (3) 433-8
  • 30 Roger G, Tran Ba Huy P, Froehlich P, Van Den Abbeele T, Klossek JM, Serrano E , et al. Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: trends and limits. Arch Otolaryngol Head Neck Surg 2002; 128 (8) 928-35
  • 31 Li JR, Qian J, Shah XZ. Evaluation of the effectiveness of preoperative embolization in surgery for nasopharyngeal angiofibroma. Arch Otolaryngol Head Neck Surg 1998; 255: 430-2
  • 32 Moulin G, Chagnaud C, Gras R, Gueguen E, Dessi P, Gaubert JY , et al. Juvenile nasopharyngeal angiofibroma: comparison of blood loss during removal in embolized group versus nonembolized group. Cardiovasc Intervent Radiol 1995; 18 (3) 158-61
  • 33 Christensen NP, Smith DS, Barnwell SL, Wax MK. Arterial embolization in the management of posterior epistaxis. Arch Otolaryngol Head Neck Surg 2005; 133 (5) 748-53
  • 34 Petruson K, Rodriguez CM, Petrusin B, Finizia C. Juvenile nasopharyngeal angiofibroma: long-term results in preoperative embolized and nonembolized patients. Acta Otolaryngol 2002; 122 (1) 96-100
  • 35 McCombe A, Lund VJ, Howard DJ. Recurrence in juvenile angiofibroma. Rhinology. Acta Otolaryngol 1990; 28: 97-102
  • 36 Gay I, Elidan J, Gordon R. Oronasal fistula a possible complication of preoperative embolization in the management of juvenile nasopharyngeal angiofibroma. J Laryngol Otol 1983; 97 (7) 651-6
  • 37 Gomes LF, Morelo MZ, Oliveira CA. Angiofibroma de nasofaringe:Controle do sangramento intraoperatótio por oclusão parcial das carótidas externas. Braz J Otorhinolaryngol 1984; 11 (6) 167-9