Subscribe to RSS

DOI: 10.5999/aps.2016.43.5.418
Feasibility of the Use of RapiGraft and Skin Grafting in Reconstructive Surgery
Authors
Background Skin grafting is a relatively simple and thus widely used procedure. However, the elastic and structural quality of grafted skin is poor. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. The present study aims to determine the feasibility of RapiGraft as a new dermal substitute.
Methods This prospective study included 20 patients with partial- or full-thickness skin defects; the patients were enrolled between January 2013 and March 2014. After skin defect debridement, the wound was divided into two parts by an imaginary line. Split-thickness skin grafting alone was performed on one side (group A), and RapiGraft and split-thickness skin grafting were used on the other side (group B). All patients were evaluated using photographs and self-questionnaires. The Manchester scar scale (MSS), a chromameter, and a durometer were used for the scar evaluation. The average follow-up period was 6 months.
Results The skin graft take rates were 93% in group A and 89% in group B, a non-significant difference (P=0.082). Statistically, group B had significantly lower MSS, vascularity, and pigmentation results than group A (P<0.05 for all). However, the groups did not differ significantly in pliability (P=0.155).
Conclusions The present study indicates that a simultaneous application of RapiGraft and a split-thickness skin graft is safe and yields improved results. Therefore, we conclude that the use of RapiGraft along with skin grafting will be beneficial for patients requiring reconstructive surgery.
This work was presented at the 72nd Congress of the Korean Society of Plastic and Reconstructive Surgeons on November 9, 2014, in Seoul, Korea.
Publication History
Received: 07 November 2015
Accepted: 28 June 2016
Article published online:
20 April 2022
© 2016. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
REFERENCES
- 1 Haslik W, Kamolz LP, Manna F. et al. Management of full-thickness skin defects in the hand and wrist region: first long-term experiences with the dermal matrix Matriderm. J Plast Reconstr Aesthet Surg 2010; 63: 360-364
- 2 Yannas IV, Burke JF. Design of an artificial skin: I. Basic design principles. J Biomed Mater Res 1980; 14: 65-81
- 3 Lamme EN, de Vries HJ, van Veen H. et al. Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs. J Histochem Cytochem 1996; 44: 1311-1322
- 4 Groos N, Guillot M, Zilliox R. et al. Use of an artificial dermis (Integra) for the reconstruction of extensive burn scars in children: about 22 grafts. Eur J Pediatr Surg 2005; 15: 187-192
- 5 King WW, Lam PK, Liew CT. et al. Evaluation of artificial skin (Integra) in a rodent model. Burns 1997; 23 (Suppl. 01) S30-S32
- 6 Burke JF, Yannas IV, Quinby Jr WC. et al. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981; 194: 413-428
- 7 Beausang E, Floyd H, Dunn KW. et al. A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 1998; 102: 1954-1961
- 8 Fearmonti R, Bond J, Erdmann D. et al. A review of scar scales and scar measuring devices. Eplasty 2010; 10: e43
- 9 van Zuijlen PP, Vloemans JF, van Trier AJ. et al. Dermal substitution in acute burns and reconstructive surgery: a subjective and objective long-term follow-up. Plast Reconstr Surg 2001; 108: 1938-1946
- 10 van Zuijlen PP, van Trier AJ, Vloemans JF. et al. Graft survival and effectiveness of dermal substitution in burns and reconstructive surgery in a one-stage grafting model. Plast Reconstr Surg 2000; 106: 615-623
- 11 Wainwright D, Madden M, Luterman A. et al. Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns. J Burn Care Rehabil 1996; 17: 124-136
- 12 Song E, Yeon Kim S, Chun T. et al. Collagen scaffolds derived from a marine source and their biocompatibility. Biomaterials 2006; 27: 2951-2961
- 13 Pati F, Adhikari B, Dhara S. Isolation and characterization of fish scale collagen of higher thermal stability. Bioresour Technol 2010; 101: 3737-3742
- 14 Bottcher-Haberzeth S, Biedermann T, Schiestl C. et al. Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats. Pediatr Surg Int 2012; 28: 171-177
- 15 Park SN, Park JC, Kim HO. et al. Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linking. Biomaterials 2002; 23: 1205-1212
- 16 Sun HW, Feigal RJ, Messer HH. Cytotoxicity of glutaraldehyde and formaldehyde in relation to time of exposure and concentration. Pediatr Dent 1990; 12: 303-307
- 17 Ryssel H, Germann G, Kloeters O. et al. Dermal substitution with Matriderm® in burns on the dorsum of the hand. Burns 2010; 36: 1248-1253
- 18 Hansbrough JF, Dore C, Hansbrough WB. Clinical trials of a living dermal tissue replacement placed beneath meshed, split-thickness skin grafts on excised burn wounds. J Burn Care Rehabil 1992; 13: 519-529
- 19 Ryssel H, Gazyakan E, Germann G. et al. The use of MatriDerm in early excision and simultaneous autologous skin grafting in burns: a pilot study. Burns 2008; 34: 93-97
- 20 Cervelli V, Brinci L, Spallone D. et al. The use of MatriDerm® and skin grafting in post-traumatic wounds. Int Wound J 2011; 8: 400-405