Analysis of the hemotherapy support in an oncology hospital considering the COVID-19 pandemic

ABSTRACT

Objectives: The purpose of this study was to analyze the impact of COVID-19 on the use of blood components in an oncology hospital.

Material and Methods: Retrospective cross-sectional quantitative nature cohort, with comparative analysis of blood component requests by an oncology hospital in the city of Juiz de Fora, Minas Gerais, Brazil, in 2019 and 2020.

Results: There was a reduction of 14.36% in the requests for blood components at the oncology service in 2020 (p-value = 0,002), with a reduction of 27.33% for platelet concentrate (p-value = 0,006). The rate of attendance of Hemominas to requests for blood components at the oncology hospital was 97.99% in 2019 and 94.36% in 2020.

Conclusion: The pandemic affected blood collection and supply due to the decrease in blood donors' attendance. The suspension of elective surgeries and the rational prescription of blood components allowed the rate of attendance maintenance by the blood bank. In this scenario, it is important to monitor the supply and demand for blood components in hospitals and apply strategies that optimize their use.

RESUMO

Objetivos: O objetivo deste estudo foi analisar o impacto da COVID-19 no uso de hemocomponentes em um hospital oncológico.

Material e Métodos: Coorte retrospectiva transversal de natureza quantitativa, com análise comparativa das solicitações de hemocomponentes por um hospital oncológico da cidade de Juiz de Fora, Minas Gerais, Brasil, em 2019 e 2020.

Resultados: Houve redução de 14,36% nas solicitações de hemocomponentes no serviço de oncologia em 2020 (p-valor = 0,002), com redução de 27,33% para concentrado de plaquetas (p-valor = 0,006). A taxa de atendimento do Hemominas às solicitações de hemocomponentes no hospital oncológico foi de 97,99% em 2019 e 94,36% em 2020.

Conclusão: A pandemia afetou a coleta e oferta de sangue devido à diminuição do atendimento de doadores de sangue. A suspensão de cirurgias eletivas e a prescrição racional de hemocomponentes permitiram a manutenção do índice de atendimento pelo banco de sangue. Nesse cenário, é importante monitorar a oferta e a demanda de hemocomponentes nos hospitais e aplicar estratégias que otimizem seu uso.

Keywords:

Blood transfusion - SARS-CoV-2 - Oncology service, Hospital - Hemotherapy service - Surgical oncology

Descritores:

Transfusão de sangue - SARS-CoV-2 - Serviço de Oncologia, Hospital - Serviço de hemoterapia - Oncologia Cirúrgica

Publication History

Received: 15 July 2022

Accepted: 05 August 2022

Article published online:
13 October 2022

• REFERENCES

• 1 Ludwig S, Zarbock A. Coronaviruses and SARS-CoV-2: a brief overview. Anesth Anaig 2020; Jul; 131 (01) 93-96
• 2 Salzberger B, Buder F, Lampl B, Ehrenstein B, Hitzenbichler F, Hanses F. Epidemiologie von SARS-CoV-2-infektion und COVID-19. Internist (Berl) 2020; 61 (08) 782-788
• 3 Singh G, Nahirniak S, Arora R, Légaré JF, Kanji HD, Nagpal D. et al. Transfusion Thresholds for adult respiratory extracorporeal life support: an expert consensus document. Can J Cardiol 2020; Sep; 36 (09) 1550-1553
• 4 Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL. et al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest 2020; Jun; 130 (06) 2757-2765
• 5 Doyle AJ, Danaee A, Furtado CI, Miller S, Maggs T, Robinson SE. et al. Blood component use in critical care in patients with COVID-19 infection: a single-centre experience. Br J Haematol 2020; Nov; 191 (03) 382-385
• 6 DeSimone RA, Costa VA, Kane K, Sepulveda JL, Ellsworth GB, Gulick RM. et al. Blood component utilization in COVID-19 patients in New York City: Transfusions do not follow the curve. Transfusion 2021; Mar; 61 (03) 692-698
• 7 White J. International Society of Blood Transfusion (ISBT). Transfusion Today 2020; 123: 2-3
• 8 Pagano MB, Hess JR, Tsang HC, Staley E, Gernsheimer T, Sen N. et al. Prepare to adapt: blood supply and transfusion support during the first 2 weeks of the 2019 novel coronavirus (COVID-19) pandemic affecting Washington State. Transfusion 2020; May; 60 (05) 908-911
• 9 Shander A, Goobie SM, Warner MA, Aapro M, Bisbe E, Perez-Calatayud AA. et al. International Foundation of Patient Blood Management (IFPBM) and Society for the Advancement of Blood Management (SABM) Work Group. Essential role of patient blood management in a pandemic: a call for action. Anesth Analg 2020; Jul; 131 (01) 74-85
• 10 Stanworth SJ, New HV, Apelseth TO, Brunskill S, Cardigan R, Doree C. et al. Effects of the COVID-19 pandemic on supply and use of blood for transfusion. Lancet Haematol 2020; Oct; 7 (10) e756-e764
• 11 Silva-Malta MC, Rodrigues DOW, Chaves DG, Magalhães NN, Ribeiro MA, Cioffi JG. et al. Impact of COVID-19 in the attendance of blood donors and production on a Brazilian Blood Centres. Transfus Med 2021; Jun; 31 (03) 206-212
• 12 Gupta AM, Ojha S, Poojary M, Sumathi SH, Nagaraju P, Dhokle R. Organization of the outdoor blood donation drives amid novel coronavirus pandemic and national lockdown: an experience from a tertiary care oncology institution in India. Transfus Apher Sci 2020; Oct; 59 (05) 102878-102878
• 13 Politis C, Papadaki M, Politi L, Kourti G, Richardson C, Asariotou M. et al. Post-donation information and haemovigilance reporting for COVID-19 in Greece: Information supporting the absence of SARS-CoV-2 possible transmission through blood components. Transfus Clin Biol 2020; Feb; 28 (01) 55-59
• 14 Weinkove R, McQuilten ZK, Adler J, Agar MR, Blyth E, Cheng AC. et al. Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Med J Aust 2020; Jun; 212 (10) 481-489
• 15 Sofis. Hemote plus [software] [Internet]. Rio de Janeiro: Sofis; 2016. ; [access in 2022 Jan 09]. Available from: https://www.sofis.com.br/solucoes/hemote-plus/
• 16 Bardin L. Análise de conteúdo. Lisboa: Edições 70; 1977
• 17 Nieto-Calvache AJ, Quintero-Santacruz M, Macia-Mejía C, López-Girón MC, Vergara-Galliadi LM, Ariza F. Dangerous shortage of blood banks as an indirect effect of SARS-CoV-2: an obstetrics perspective. Int J Gynaecol Obstet 2020; Dec; 151 (03) 424-430
• 18 Tartarone A, Lerose R. COVID-19 and cancer care: what do international guidelines say?. Med Oncol 2020; Aug; 37 (09) 80-80
• 19 Patel R, Park J, Shah A, Saif MW. COVID-19 and cancer patients. Cancer Med J 2020; 3 (01) 40-48
• 20 Curigliano G, Banerjee S, Cervantes A, Garassino MC, Garrido P, Girard N. et al. Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus. Ann Oncol 2020; Oct; 31 (10) 1320-1335
• 21 National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: delivery of systemic anticancer treatments. London: National Institute for Health and Care Excellence (NICE); 2021
• 22 You B, Ravaud A, Canivet A, Ganem G, Giraud P, Guimbaud R. et al. The official French guidelines to protect patients with cancer against SARS-CoV-2 infection. Lancet Oncol 2020; May; 21 (05) 619-621
• 23 Sociedade Brasileira de Cirurgia Oncológica (SBCO). Considerações sobre opções de manejo de neoplasias durante a pandemia pelo COVID-19 [Internet]. Rio de Janeiro: SBCO; 2020. [access in 2012 Apr 3]; 1-44 Available from: https://sbco.org.br/wp-content/uploads/2020/04/SBCO-CONSIDERAC%CC%A70%CC%83ES-SOBRE-OPC%CC%A70%CC%83ES-DE-MANEJO-DE-NEOPLASIAS-DURANTE-A-PANDEMIA-PELO-COVID-19.pdf
• 24 Radhakrishnan VS, Nair RKS, Goel G, Ramanan V, Chandy M, Nair R. COVID-19 and haematology services in a cancer centre from a middle-income country: adapting service delivery, balancing the known and unknown during the pandemic. Ecancermedicalscience 2020; Sep; 14: 1110-1110
• 25 Iqbal N, Haider K, Sundaram V, Radosevic J, Burnouf T, Seghatchian J. et al. Red blood cell transfusion and outcome in cancer. Transfus Apher Sci 2017; Jun; 56 (03) 287-290
• 26 Tzounakas VL, Seghatchian J, Grouzi E, Kokoris S, Antonelou MH. Red blood cell transfusion in surgical cancer patients: targets, risks, mechanistic understanding and further the rapeutic opportunities. Transfus Apher Sci 2017; Jun; 56 (03) 291-304
• 27 Ngo A, Masel D, Cahill C, Blumberg N, Refaai MA. Blood banking and transfusion medicine challenges during the COVID-19 pandemic. Clin Lab Med 2020; Dec; 40 (04) 587-601
• 28 Al-Riyami AZ, Abdella YE, Badawi MA, Panchatcharam SM, Ghaleb Y, Maghsudlu M. et al. The impact of COVID-19 pandemic on blood supplies and transfusion services in Eastern Mediterranean Region. Transfus Clin Biol 2021; Feb; 28 (01) 16-24
• 29 Saab R, Obeid A, Gachi F, Boudiaf H, Sargsyan L, Al-Saad K. et al. Impact of the Coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group. Cancer 2020; Sep; 126 (18) 4235-4245
• 30 Lopes JAS, Medeiros RL, Santos OF, Magalhães NNS, Rodrigues LOW, Rodrigues Neto AA. et al. Utilização de hemocomponentes em Hospital Geral de Juiz de Fora. Braz J Health Rev 2020; Nov; 3 (06) 16808-16820
• 31 Velázquez-Kennedy K, Luna A, Sánchez-Tornero A, Jiménez-Chillón C, Jiménez-Martín A, Vallés Carboneras A. et al. Transfusion support in COVID-19 patients: impact on hospital blood component supply during the outbreak. Transfusion 2021; Feb; 61 (02) 361-367
• 32 Hemingway JF, Singh N, Starnes BW. Emerging practice patterns in vascular surgery during the COVID-19 pandemic. J Vasc Surg 2020; Aug; 72 (02) 396-402
• 33 Raturi M, Kusum A. The blood supply management amid the COVID-19 outbreak. Transfus Clin Biol 2020; Aug; 27 (03) 147-151
• 34 Pandey HC, Coshic P, Chippy CS, Arcot PJ, Kumar K. Blood supply management in times of SARS-CoV-2 pandemic - challenges, strategies adopted, and the lessons learned from the experience of a hospital-based blood centre. Vox Sang 2021; May; 116 (05) 497-503
• 35 Hernández-Maraver D, Viejo A, Kerguelén AE, Jiménez-Yuste V. Transfusion medicine during COVID-19 outbreak in the hotspot of Spain. Transfusion 2020; Nov; 60 (11) 2762-2764
• 36 Wang Y, Han W, Pan L, Wang C, Liu Y, Hu W. et al. Impact of COVID-19 on blood centres in Zhejiang province China. Vox Sang 2020; Aug; 115 (06) 502-506
• 37 Ranganathan P, Ahmed S, Kulkarni AP, Duvatia JV. Appropriateness of perioperative blood transfusion in patients undergoing cancer surgery: a prospective single-centre study. Indian J Anaesth 2012; May; 56 (03) 234-237
• 38 Borchardt AC, Azevedo-Silva F, Amorim Filho LM. Blood components requests at an orthopedic hospital: a critical survey. Hematol Transfus Cell Ther 2020; Jan/Mar; 42 (01) 25-32