RESUMO
Background: New antineoplastic agents have increased the survival rate of cancer patients, however,
the incidence of cutaneous skin toxicity, which leads to worsening in the quality
of life and to the necessity of interrupting the treatment, continues presently. Natural
agents, as Aloe vera and Calendula, have been suggested as potential ways of prevention
and treatment for radiation dermatitis resulting from radiotherapy, providing better
adhesion to the therapies and improving the wellbeing of the patients.
Purpose: To evaluate the cutaneous acceptability and hydrating effect of four topical test
products in patients undergoing radiotherapy and antineoplastic treatment.
Methods: Both sex participants, undergoing oncological treatments, were included. Patients
received a prescription to self-applied topical test products - A (Washcare), B (Moistcare),
C (Extremecare) and D (Coolcare Mask) during 30 days. Products acceptability and skin
hydration were evaluated considering the occurrence of skin adverse reaction, participants
self-reported feelings of skin discomfort, dermatologist and instrumental skin hydration
evaluation.
Results: Thirty-three participants initiated and completed the study. None of them had skin
reactions or discomfort in the area of application, and no adverse events were reported.
Twenty-five participants (75.8%) reported improvement in skin hydration after using
the test products, while eight participants (24.2%) observed the maintenance of hydration
(p<0,005).
Conclusion: The products evaluated showed improvement in skin condition in most patients, increased
hydration and good skin acceptability in patients with skin toxicities caused by the
cancer treatments.
Keywords:
Calendula - Radiodermatitis - Aloe - Wounds and Injuries - Skin - Toxicity.
Bibliographical Record
Carlos D'App Santos Machado-Filho, Odimila Kawahata Adriano Silva, Silvia Regina Lamas.
Cutaneous Acceptability And Hydratation of Topical Products In Patients Undergoing
Radiotherapy and Antineoplastic Treatment. Brazilian Journal of Oncology 2021; 17:
e-20210005.
DOI: 10.5935/2526-8732.20210005
